PPK21_SCHPO - dbPTM
PPK21_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPK21_SCHPO
UniProt AC Q9Y7J6
Protein Name Serine/threonine-protein kinase ppk21
Gene Name ppk21
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 551
Subcellular Localization Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body . Located at the cell tips and septum.
Protein Description
Protein Sequence MMDLEHKRISRSTLPDYADPDYFEARGERNPVKPQSSNVVPGTSHIGSIKSPADYVFGDIIGDGSFSKVRRATDKKSWKEYAIKVLDKKYIVKENKVKYVNIERDSMMRLNGFPGISRLFHTFQDDLKLYYVLELAPNGELLQYIKKYRFLDENCVRFYAAEILSSIEYMHSCGIIHRDLKPENILFDGNMHVKITDFGTAKILPPKYVNSPDYTTFPSSFVGTAEYVAPELLSRQVVSKSSDLWAFACVVYQMIVGSPPFHGSNPNNIFKKIMSLEYELPKLLPPDIVPLFSHLFRIQPSDRSTTQQIKQFPFFATITWDNLWTQDPPPMQSFRPNYNIAIPNAPAYYRSNVTAAAAANAAAAFASASIVKHQETARRQELPTVNRFTAPTAHYGYASLRSHQMPVDRLYYKLVPSSESIIESTSVFVSPIPSVPEGNKFPSGLSKMFLKRKQRVMLLTDVGRCAFVCKGKHERLFIEMEVNLKDSSVVVIFDENSSKRFLIEDKVQSWIIEDSSGDVTKYKDKILKFADVASSHQSRSSEENVEENEEE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationDLEHKRISRSTLPDY
CCCCCCCCCCCCCCC		24.9825720772
12PhosphorylationEHKRISRSTLPDYAD
CCCCCCCCCCCCCCC		27.7529996109
13PhosphorylationHKRISRSTLPDYADP
CCCCCCCCCCCCCCC		41.0029996109
65PhosphorylationGDIIGDGSFSKVRRA
CCEECCCCHHHCCCC		30.9625720772
220PhosphorylationDYTTFPSSFVGTAEY
CCCCCCHHHCCCHHH		24.96-
397PhosphorylationAPTAHYGYASLRSHQ
CCCCCCCHHHHHHCC		5.9527738172
534PhosphorylationLKFADVASSHQSRSS
HHHHHHHHHCCCCCC		28.3524763107
535PhosphorylationKFADVASSHQSRSSE
HHHHHHHHCCCCCCH		18.7924763107
538PhosphorylationDVASSHQSRSSEENV
HHHHHCCCCCCHHCH		28.8028889911
540PhosphorylationASSHQSRSSEENVEE
HHHCCCCCCHHCHHH		47.5524763107
541PhosphorylationSSHQSRSSEENVEEN
HHCCCCCCHHCHHHH		48.0621712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPK21_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPK21_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPK21_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARP10_SCHPOSPBC56F2.03genetic
22681890
SLT1_SCHPOslt1genetic
22681890
YDO6_SCHPOSPAC15A10.06genetic
22681890
AP3B_SCHPOapl6genetic
22681890
MDL1_SCHPOmdl1genetic
22681890
ARF6_SCHPOarf6genetic
22681890
YEN1_SCHPOSPAC11G7.01genetic
22681890
YAI8_SCHPOSPAC24B11.08cgenetic
22681890
IES4_SCHPOies4genetic
22681890
YAC5_SCHPOcph1genetic
22681890
YHG1_SCHPOfmd2genetic
22681890
YDA5_SCHPOSPAC1F12.05genetic
22681890
FUS1_SCHPOfus1genetic
22681890
ALF1_SCHPOalf1genetic
22681890
ADDH_SCHPOSPBC1289.14genetic
22681890
TMA20_SCHPOtma20genetic
22681890
PPR8_SCHPOppr8genetic
22681890
NAA35_SCHPOmak10genetic
22681890
SET3_SCHPOset3genetic
22681890
ATL1_SCHPOatl1genetic
22681890
ASH2_SCHPOash2genetic
22681890
YLY4_SCHPOSPAC186.04cgenetic
22681890
YEMB_SCHPOSPAC29B12.11cgenetic
22681890
ALG5_SCHPOalg5genetic
22681890
AROG_SCHPOSPAP8A3.07cgenetic
22681890
ELP3_SCHPOelp3genetic
22681890
YGE9_SCHPOSPBC1347.09genetic
22681890
VPS72_SCHPOswc2genetic
22681890
YGVA_SCHPOdef1genetic
22681890
YF94_SCHPOSPAC10F6.04genetic
22681890
PUN1_SCHPOpun1genetic
22681890
RL38A_SCHPOrpl3801genetic
22681890
ROK1_SCHPOrok1genetic
22681890
BCS1_SCHPOSPAC644.07genetic
22681890
RLA6_SCHPOrpp203genetic
22681890
PFD6_SCHPOSPAC3A11.13genetic
22681890
TOM70_SCHPOtom70genetic
22681890
YAM5_SCHPOmso1genetic
22681890
SUM2_SCHPOsum2genetic
22681890
DAD2_SCHPOdad2genetic
22681890
CDB4_SCHPOcdb4genetic
22681890
TBA2_SCHPOatb2genetic
22681890
SPN1_SCHPOspn1genetic
22681890
MCL1_SCHPOmcl1genetic
22681890
YKEE_SCHPOSPAC1805.14genetic
22681890
SGF29_SCHPOsgf29genetic
22681890
OXDA_SCHPOdao1genetic
22681890
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPK21_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, AND MASSSPECTROMETRY.

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