GALT6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GALT6_HUMAN
• UniProt AC: Q8NCL4
• Protein Name: Polypeptide N-acetylgalactosaminyltransferase 6
• Gene Name: GALNT6
• Organism: Homo sapiens (Human).
• Sequence Length: 622
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides..
• Protein Sequence: MRLLRRRHMPLRLAMVGCAFVLFLFLLHRDVSSREEATEKPWLKSLVSRKDHVLDLMLEAMNNLRDSMPKLQIRAPEAQQTLFSINQSCLPGFYTPAELKPFWERPPQDPNAPGADGKAFQKSKWTPLETQEKEEGYKKHCFNAFASDRISLQRSLGPDTRPPECVDQKFRRCPPLATTSVIIVFHNEAWSTLLRTVYSVLHTTPAILLKEIILVDDASTEEHLKEKLEQYVKQLQVVRVVRQEERKGLITARLLGASVAQAEVLTFLDAHCECFHGWLEPLLARIAEDKTVVVSPDIVTIDLNTFEFAKPVQRGRVHSRGNFDWSLTFGWETLPPHEKQRRKDETYPIKSPTFAGGLFSISKSYFEHIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFRTKSPHTFPKGTSVIARNQVRLAEVWMDSYKKIFYRRNLQAAKMAQEKSFGDISERLQLREQLHCHNFSWYLHNVYPEMFVPDLTPTFYGAIKNLGTNQCLDVGENNRGGKPLIMYSCHGLGGNQYFEYTTQRDLRHNIAKQLCLHVSKGALGLGSCHFTGKNSQVPKDEEWELAQDQLIRNSGSGTCLTSQDKKPAMAPCNPSDPHQLWLFV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	O-linked_Glycosylation	VSSREEATEKPWLKS CCCHHHHHCCHHHHH	48.06	55831047
86	N-linked_Glycosylation	QQTLFSINQSCLPGF HHHHHHCCCCCCCCC	26.89	UniProtKB CARBOHYD
151	Phosphorylation	AFASDRISLQRSLGP HHHCCCHHHHHHCCC	21.24	24719451
387	Phosphorylation	GGENVEMSFRVWQCG CCCCEEEEEEEEECC	9.08	24719451
452	Methylation	RRNLQAAKMAQEKSF HHHHHHHHHHHHHCC	37.47	-
458	Phosphorylation	AKMAQEKSFGDISER HHHHHHHCCCCHHHH	33.44	22210691
476	N-linked_Glycosylation	REQLHCHNFSWYLHN HHHHHHCCHHHHHCC	37.73	UniProtKB CARBOHYD
506	O-linked_Glycosylation	GAIKNLGTNQCLDVG HHHHHCCCCCEEECC	25.86	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GALT6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GALT6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GALT6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TMEM9_HUMAN	TMEM9	physical	21988832
TAF9_HUMAN	TAF9	physical	21988832
SC5A6_HUMAN	SLC5A6	physical	21988832
NDUF6_HUMAN	NDUFAF6	physical	28514442
AT2B3_HUMAN	ATP2B3	physical	28514442
ASPH2_HUMAN	ASPHD2	physical	28514442
NDUB6_HUMAN	NDUFB6	physical	28514442
ZNT1_HUMAN	SLC30A1	physical	28514442
NDUB8_HUMAN	NDUFB8	physical	28514442
AT2B2_HUMAN	ATP2B2	physical	28514442
NDUAC_HUMAN	NDUFA12	physical	28514442
EDEM1_HUMAN	EDEM1	physical	28514442
NDUS6_HUMAN	NDUFS6	physical	28514442
GAS6_HUMAN	GAS6	physical	28514442
XYLK_HUMAN	FAM20B	physical	28514442
B4GT3_HUMAN	B4GALT3	physical	28514442
NDUB5_HUMAN	NDUFB5	physical	28514442
NDUS4_HUMAN	NDUFS4	physical	28514442
RMND1_HUMAN	RMND1	physical	28514442
SL9A1_HUMAN	SLC9A1	physical	28514442
S39AA_HUMAN	SLC39A10	physical	28514442
PLXA2_HUMAN	PLXNA2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.