| UniProt ID | NDUF6_HUMAN | |
|---|---|---|
| UniProt AC | Q330K2 | |
| Protein Name | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | |
| Gene Name | NDUFAF6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 333 | |
| Subcellular Localization |
Isoform 1: Mitochondrion inner membrane. Peripherally localized on the matrix face of the mitochondrial inner membrane. Isoform 2: Cytoplasm. Nucleus. |
|
| Protein Description | Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1.. | |
| Protein Sequence | MAASAHGSVWGPLRLGIPGLCCRRPPLGLYARMRRLPGPEVSGRSVAAASGPGAWGTDHYCLELLRKRDYEGYLCSLLLPAESRSSVFALRAFNVELAQVKDSVSEKTIGLMRMQFWKKTVEDIYCDNPPHQPVAIELWKAVKRHNLTKRWLMKIVDEREKNLDDKAYRNIKELENYAENTQSSLLYLTLEILGIKDLHADHAASHIGKAQGIVTCLRATPYHGSRRKVFLPMDICMLHGVSQEDFLRRNQDKNVRDVIYDIASQAHLHLKHARSFHKTVPVKAFPAFLQTVSLEDFLKKIQRVDFDIFHPSLQQKNTLLPLYLYIQSWRKTY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 45 | Phosphorylation | GPEVSGRSVAAASGP CCCCCCCHHHHHCCC | 21.45 | - | |
| 50 | Phosphorylation | GRSVAAASGPGAWGT CCHHHHHCCCCCCCC | 40.57 | - | |
| 105 | Phosphorylation | AQVKDSVSEKTIGLM HHHCCCCCHHHHHHH | 37.01 | 24719451 | |
| 108 | Phosphorylation | KDSVSEKTIGLMRMQ CCCCCHHHHHHHHHH | 19.07 | 24719451 | |
| 278 | Ubiquitination | KHARSFHKTVPVKAF HHHHHCCCCCCHHHH | 49.56 | - | |
| 279 | Phosphorylation | HARSFHKTVPVKAFP HHHHCCCCCCHHHHH | 22.82 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NDUF6_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NDUF6_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NDUF6_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of NDUF6_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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