DUS4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DUS4_HUMAN
• UniProt AC: Q13115
• Protein Name: Dual specificity protein phosphatase 4
• Gene Name: DUSP4
• Organism: Homo sapiens (Human).
• Sequence Length: 394
• Subcellular Localization: Nucleus .
• Protein Description: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2..
• Protein Sequence: MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGYILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MVTMEELRE ------CCCHHHHHH	7.59	25489052
3	Phosphorylation	-----MVTMEELREM -----CCCHHHHHHC	19.98	26503892
16	Ubiquitination	EMDCSVLKRLMNRDE HCCHHHHHHHHCCCC	41.13	29967540
31	Phosphorylation	NGGGAGGSGSHGTLG CCCCCCCCCCCCCCC	35.88	22210691
33	Phosphorylation	GGAGGSGSHGTLGLP CCCCCCCCCCCCCCC	22.05	-
33 (in isoform 2)	Phosphorylation	-	22.05	27251275
36	Phosphorylation	GGSGSHGTLGLPSGG CCCCCCCCCCCCCCC	16.54	23532336
39	Phosphorylation	GSHGTLGLPSGGKCL CCCCCCCCCCCCEEE	3.25	27251275
39 (in isoform 2)	Phosphorylation	-	3.25	27251275
41	Phosphorylation	HGTLGLPSGGKCLLL CCCCCCCCCCEEEEE	66.28	22210691
45	Phosphorylation	GLPSGGKCLLLDCRP CCCCCCEEEEEECHH	3.51	27251275
50	Phosphorylation	GKCLLLDCRPFLAHS CEEEEEECHHHHHHC	6.33	-
50 (in isoform 2)	Phosphorylation	-	6.33	-
52	Phosphorylation	CLLLDCRPFLAHSAG EEEEECHHHHHHCCC	34.63	-
52 (in isoform 2)	Phosphorylation	-	34.63	-
56 (in isoform 2)	Phosphorylation	-	21.96	-
56	Phosphorylation	DCRPFLAHSAGYILG ECHHHHHHCCCCCCC	21.96	-
60	Phosphorylation	FLAHSAGYILGSVNV HHHHCCCCCCCCEEC	7.84	19835603
64	Phosphorylation	SAGYILGSVNVRCNT CCCCCCCCEECCCCH	13.68	19835603
69	Ubiquitination	LGSVNVRCNTIVRRR CCCEECCCCHHHHHC	4.60	21963094
71	Phosphorylation	SVNVRCNTIVRRRAK CEECCCCHHHHHCCC	25.19	-
71	Ubiquitination	SVNVRCNTIVRRRAK CEECCCCHHHHHCCC	25.19	22817900
78	Ubiquitination	TIVRRRAKGSVSLEQ HHHHHCCCCCCCHHH	50.32	21906983
80	Phosphorylation	VRRRAKGSVSLEQIL HHHCCCCCCCHHHHC	14.07	30624053
99	Phosphorylation	EVRARLRSGLYSAVI HHHHHHHCCCCEEEE	37.43	25348772
102	Phosphorylation	ARLRSGLYSAVIVYD HHHHCCCCEEEEEEC	9.71	25348772
103	Phosphorylation	RLRSGLYSAVIVYDE HHHCCCCEEEEEECC	22.54	25348772
108	Phosphorylation	LYSAVIVYDERSPRA CCEEEEEECCCCCCH	10.85	25348772
112	Phosphorylation	VIVYDERSPRAESLR EEEECCCCCCHHHHC	19.38	17081983
117	Phosphorylation	ERSPRAESLREDSTV CCCCCHHHHCCCCHH	31.57	28348404
144	Ubiquitination	RTDICLLKGGYERFS CCCEEEEECCHHHHH	37.02	21963094
154	Phosphorylation	YERFSSEYPEFCSKT HHHHHHCCHHHHCCC	15.26	-
159	Phosphorylation	SEYPEFCSKTKALAA HCCHHHHCCCCHHHC	48.99	-
160	Ubiquitination	EYPEFCSKTKALAAI CCHHHHCCCCHHHCC	56.05	27667366
162	Ubiquitination	PEFCSKTKALAAIPP HHHHCCCCHHHCCCC	45.18	22817900
184	Phosphorylation	EPLDLGCSSCGTPLH CCCCCCCCCCCCCCC	27.19	28348404
185	Phosphorylation	PLDLGCSSCGTPLHD CCCCCCCCCCCCCCC	22.20	28348404
188	Phosphorylation	LGCSSCGTPLHDQGG CCCCCCCCCCCCCCC	27.31	28348404
220	Ubiquitination	RRDMLDALGITALLN HHHHHHHHCHHHEEE	5.21	21963094
256	Phosphorylation	DNHKADISSWFMEAI CCCCCCHHHHHHHHH	23.28	22210691
257	Phosphorylation	NHKADISSWFMEAIE CCCCCHHHHHHHHHH	25.35	22210691
265	Phosphorylation	WFMEAIEYIDAVKDC HHHHHHHHHHHHHHC	9.66	22210691
311	Ubiquitination	EEAFEFVKQRRSIIS HHHHHHHHHHCCCCC	43.33	27667366
318	Phosphorylation	KQRRSIISPNFSFMG HHHCCCCCCCCCHHH	16.48	16286470
332	Phosphorylation	GQLLQFESQVLATSC HHHHHHHHHHHHHHH	27.20	25850435
337	Phosphorylation	FESQVLATSCAAEAA HHHHHHHHHHHHHHC	21.85	25850435
338	Phosphorylation	ESQVLATSCAAEAAS HHHHHHHHHHHHHCC	8.99	25850435
345	Phosphorylation	SCAAEAASPSGPLRE HHHHHHCCCCCCCHH	27.01	25850435
347	Phosphorylation	AAEAASPSGPLRERG HHHHCCCCCCCHHCC	51.01	25850435
356	Phosphorylation	PLRERGKTPATPTSQ CCHHCCCCCCCCCHH	22.45	27251275
359	Phosphorylation	ERGKTPATPTSQFVF HCCCCCCCCCHHEEE	28.44	27251275
361	Phosphorylation	GKTPATPTSQFVFSF CCCCCCCCHHEEEEE	30.70	28348404
362	Phosphorylation	KTPATPTSQFVFSFP CCCCCCCHHEEEEEE	23.87	22210691
367	Phosphorylation	PTSQFVFSFPVSVGV CCHHEEEEEEEEEEC	24.28	28348404
371	Phosphorylation	FVFSFPVSVGVHSAP EEEEEEEEEECCCCC	17.25	28348404
376	Phosphorylation	PVSVGVHSAPSSLPY EEEEECCCCCCCCCC	39.20	22210691
379	Phosphorylation	VGVHSAPSSLPYLHS EECCCCCCCCCCCCC	44.20	28348404
380	Phosphorylation	GVHSAPSSLPYLHSP ECCCCCCCCCCCCCC	32.10	28348404
383	Phosphorylation	SAPSSLPYLHSPITT CCCCCCCCCCCCCCC	23.49	28348404
386	Phosphorylation	SSLPYLHSPITTSPS CCCCCCCCCCCCCCC	18.53	22322096
389	Phosphorylation	PYLHSPITTSPSC-- CCCCCCCCCCCCC--	25.30	22210691
390	Phosphorylation	YLHSPITTSPSC--- CCCCCCCCCCCC---	39.08	28348404
391	Phosphorylation	LHSPITTSPSC---- CCCCCCCCCCC----	13.23	22322096

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
386	S	Phosphorylation	Kinase	ERK1	P27361	PSP
386	S	Phosphorylation	Kinase	MAPK	-	Uniprot
391	S	Phosphorylation	Kinase	ERK1	P27361	PSP
391	S	Phosphorylation	Kinase	MAPK	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DUS4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DUS4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MK03_HUMAN	MAPK3	physical	11387337
MK14_HUMAN	MAPK14	physical	11387337
MK08_HUMAN	MAPK8	physical	11387337
A4_HUMAN	APP	physical	21832049
MK03_HUMAN	MAPK3	physical	19843478
MK08_HUMAN	MAPK8	physical	19843478
MK09_HUMAN	MAPK9	physical	25241761
EIF3C_HUMAN	EIF3C	physical	27880917
MK01_HUMAN	MAPK1	physical	27880917
DUS4_HUMAN	DUSP4	physical	27432908
MK03_HUMAN	MAPK3	physical	27432908
MK01_HUMAN	MAPK1	physical	27432908
WDR34_HUMAN	WDR34	physical	27432908
COA7_HUMAN	COA7	physical	27432908
ABHEB_HUMAN	ABHD14B	physical	27432908
VPS29_HUMAN	VPS29	physical	27432908
PRDX5_HUMAN	PRDX5	physical	27432908
PPIA_HUMAN	PPIA	physical	27432908
MK14_HUMAN	MAPK14	physical	27432908
PARK7_HUMAN	PARK7	physical	27432908
AP3S1_HUMAN	AP3S1	physical	27432908
ES1_HUMAN	C21orf33	physical	27432908
NXN_HUMAN	NXN	physical	27432908
DHB4_HUMAN	HSD17B4	physical	27432908
SDHA_HUMAN	SDHA	physical	27432908
ACTY_HUMAN	ACTR1B	physical	27432908
MP2K6_HUMAN	MAP2K6	physical	27432908
DUS12_HUMAN	DUSP12	physical	27432908
NUP50_HUMAN	NUP50	physical	27432908
DS13A_HUMAN	DUSP13	physical	27432908
DS13B_HUMAN	DUSP13	physical	27432908
TNPO3_HUMAN	TNPO3	physical	27432908
UB2L3_HUMAN	UBE2L3	physical	27432908
8ODP_HUMAN	NUDT1	physical	27432908
NUD10_HUMAN	NUDT10	physical	27432908
RN187_HUMAN	RNF187	physical	27432908
BACH_HUMAN	ACOT7	physical	27432908
AMRA1_HUMAN	AMBRA1	physical	27432908
PRDX6_HUMAN	PRDX6	physical	27432908
SPEE_HUMAN	SRM	physical	27432908
MTCH2_HUMAN	MTCH2	physical	27432908
QKI_HUMAN	QKI	physical	27432908

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.