CLC11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLC11_HUMAN
• UniProt AC: Q9Y240
• Protein Name: C-type lectin domain family 11 member A
• Gene Name: CLEC11A
• Organism: Homo sapiens (Human).
• Sequence Length: 323
• Subcellular Localization: Cytoplasm . Secreted .
• Protein Description: Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts. [PubMed: 27976999 Important for repair and maintenance of adult bone (By similarity]
• Protein Sequence: MQAAWLLGALVVPQLLGFGHGARGAEREWEGGWGGAQEEEREREALMLKHLQEALGLPAGRGDENPAGTVEGKEDWEMEEDQGEEEEEEATPTPSSGPSPSPTPEDIVTYILGRLAGLDAGLHQLHVRLHALDTRVVELTQGLRQLRNAAGDTRDAVQALQEAQGRAEREHGRLEGCLKGLRLGHKCFLLSRDFEAQAAAQARCTARGGSLAQPADRQQMEALTRYLRAALAPYNWPVWLGVHDRRAEGLYLFENGQRVSFFAWHRSPRPELGAQPSASPHPLSPDQPNGGTLENCVAQASDDGSWWDHDCQRRLYYVCEFPF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Ubiquitination	EREALMLKHLQEALG HHHHHHHHHHHHHHC	28.44	22817900
69	O-linked_Glycosylation	GDENPAGTVEGKEDW CCCCCCCCCCCHHCC	19.93	55828147
95	O-linked_Glycosylation	EEATPTPSSGPSPSP HHCCCCCCCCCCCCC	50.86	OGP
101	O-linked_Glycosylation	PSSGPSPSPTPEDIV CCCCCCCCCCHHHHH	45.82	OGP
103	O-linked_Glycosylation	SGPSPSPTPEDIVTY CCCCCCCCHHHHHHH	43.58	OGP
179	Ubiquitination	GRLEGCLKGLRLGHK CCHHHHHHHHHHCCE	61.03	-
186	Ubiquitination	KGLRLGHKCFLLSRD HHHHHCCEEEEECCC	25.53	-
277	O-linked_Glycosylation	PELGAQPSASPHPLS HHHCCCCCCCCCCCC	29.33	OGP
279	O-linked_Glycosylation	LGAQPSASPHPLSPD HCCCCCCCCCCCCCC	28.25	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLC11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLC11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLC11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PKP4_HUMAN	PKP4	physical	26186194
RNF13_HUMAN	RNF13	physical	26186194
NU214_HUMAN	NUP214	physical	26186194
LAMC1_HUMAN	LAMC1	physical	26186194
BIRC2_HUMAN	BIRC2	physical	26186194
NUP98_HUMAN	NUP98	physical	26186194
BIRC6_HUMAN	BIRC6	physical	26186194
DCAM_HUMAN	AMD1	physical	26186194
ZY11B_HUMAN	ZYG11B	physical	26186194
RGPD5_HUMAN	RGPD5	physical	26186194
SUGP2_HUMAN	SUGP2	physical	26186194
MYCB2_HUMAN	MYCBP2	physical	26186194
FBX28_HUMAN	FBXO28	physical	26186194
VWA8_HUMAN	VWA8	physical	26186194
TRAF7_HUMAN	TRAF7	physical	26186194
XIAP_HUMAN	XIAP	physical	26186194
RPOM_HUMAN	POLRMT	physical	26186194
CEP85_HUMAN	CEP85	physical	26186194
BCOR_HUMAN	BCOR	physical	26186194
ZN106_HUMAN	ZNF106	physical	26186194
AKAP8_HUMAN	AKAP8	physical	26186194
PRC2B_HUMAN	PRRC2B	physical	26186194
FAF2_HUMAN	FAF2	physical	26186194
MD1L1_HUMAN	MAD1L1	physical	26186194
IKIP_HUMAN	IKBIP	physical	26186194
Z518A_HUMAN	ZNF518A	physical	26186194
GALC_HUMAN	GALC	physical	26186194
UBP54_HUMAN	USP54	physical	26186194
PATZ1_HUMAN	PATZ1	physical	26186194
TRAF2_HUMAN	TRAF2	physical	26186194
TGT_HUMAN	QTRT1	physical	26186194
FA83B_HUMAN	FAM83B	physical	26186194
SAV1_HUMAN	SAV1	physical	26186194
FBX28_HUMAN	FBXO28	physical	28514442
FAF2_HUMAN	FAF2	physical	28514442
ZN106_HUMAN	ZNF106	physical	28514442
FA83B_HUMAN	FAM83B	physical	28514442
PKP4_HUMAN	PKP4	physical	28514442
IKIP_HUMAN	IKBIP	physical	28514442
DCAM_HUMAN	AMD1	physical	28514442
XIAP_HUMAN	XIAP	physical	28514442
MD1L1_HUMAN	MAD1L1	physical	28514442
RNF13_HUMAN	RNF13	physical	28514442
GALC_HUMAN	GALC	physical	28514442
VWA8_HUMAN	VWA8	physical	28514442
MYCB2_HUMAN	MYCBP2	physical	28514442
Z518A_HUMAN	ZNF518A	physical	28514442
BIRC2_HUMAN	BIRC2	physical	28514442
RPOM_HUMAN	POLRMT	physical	28514442
SAV1_HUMAN	SAV1	physical	28514442
ZY11B_HUMAN	ZYG11B	physical	28514442
SUGP2_HUMAN	SUGP2	physical	28514442
CEP85_HUMAN	CEP85	physical	28514442
LAMC1_HUMAN	LAMC1	physical	28514442
ZN865_HUMAN	ZNF865	physical	28514442
PRC2B_HUMAN	PRRC2B	physical	28514442
UBP54_HUMAN	USP54	physical	28514442
TGT_HUMAN	QTRT1	physical	28514442
PATZ1_HUMAN	PATZ1	physical	28514442
FBSP1_HUMAN	FBXO45	physical	28514442
TRAF7_HUMAN	TRAF7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.