| UniProt ID | CALYP_DROME | |
|---|---|---|
| UniProt AC | Q7K5N4 | |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase calypso | |
| Gene Name | calypso | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 471 | |
| Subcellular Localization | Nucleus. Localizes to PcG response elements (PREs). | |
| Protein Description | Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.. | |
| Protein Sequence | MNAAGGGSGAQAAAVAAGNNSLSHNALLSTASGATTMPMAQLADGWLELESDPGLFTLLLKDFGCHDVQVEEVYDLQKPIESPYGFIFLFRWIEERRARRKIVETTAEIFVKDEEAISSIFFAQQVVPNSCATHALLSVLLNCNENNLQLGDTLSRLKTHTKGMSPENKGLAIGNTPELACAHNSHAMPQARRRLERTGAGVSSCRFTGEAFHFVSFVPINGQLFELDGLKPYPMNHGGWEDSEDWTDKFRRVMAERLGIATGEQDIRFNLMAVVPDRRIAITHKLKMLRTNQAIVSGTLQKLLKADEQGESGNGDSQRPDTPTTLLEPSAFTARDLQSLLKNLDTEIAINEQHLADENDRRHMFKVDASRRTHNYDKFICTFLSMLAHQGVLGELVSQHLLPSKKVSGQGAANRISKQSTTASAGGSTAAGTASTPKTQQQQAAAAKNGKSPSKTPGRRRKGRNKCRKRK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of CALYP_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CALYP_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CALYP_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CALYP_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ASX_DROME | Asx | physical | 20436459 | |
| PEP_DROME | Pep | physical | 20436459 | |
| HSP7D_DROME | Hsc70-4 | physical | 20436459 | |
| TBB1_DROME | betaTub56D | physical | 20436459 | |
| TBA1_DROME | alphaTub84B | physical | 20436459 | |
| RS3A_DROME | RpS3A | physical | 20436459 | |
| EF1A2_DROME | Ef1alpha100E | physical | 20436459 | |
| RS9_DROME | RpS9 | physical | 20436459 | |
| RS27A_DROME | RpS27A | physical | 20436459 | |
| TBA4_DROME | alphaTub67C | physical | 20436459 | |
| MYSN_DROME | zip | physical | 20436459 | |
| RL13_DROME | RpL13 | physical | 20436459 | |
| RS6_DROME | RpS6 | physical | 20436459 | |
| ACT3_DROME | Act57B | physical | 20436459 | |
| LVA_DROME | lva | physical | 20436459 | |
| RL8_DROME | RpL8 | physical | 20436459 | |
| RL4_DROME | RpL4 | physical | 20436459 | |
| R10AB_DROME | RpL10Ab | physical | 20436459 | |
| RS17_DROME | RpS17 | physical | 20436459 | |
| RL15_DROME | RpL15 | physical | 20436459 | |
| RL11_DROME | RpL11 | physical | 20436459 | |
| RS19A_DROME | RpS19a | physical | 20436459 | |
| RL7A_DROME | RpL7A | physical | 20436459 | |
| H2A_DROME | His2A:CG33865 | physical | 20436459 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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