| UniProt ID | ATG13_SCHPO | |
|---|---|---|
| UniProt AC | O36019 | |
| Protein Name | Autophagy protein 13 | |
| Gene Name | atg13 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 758 | |
| Subcellular Localization | Cytoplasm . Preautophagosomal structure . | |
| Protein Description | Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Autophagy functions to supply nitrogen and is activated when cells cannot access exogenous nitrogen, thus ensuring that they can adapt and subsequently propagate. Finally, atg13 is also required for glycogen storage during stationary phase and has a role in meiosis and sporulation.. | |
| Protein Sequence | MPRLNTQLPRMYSAPPGHSKAVSTELNKDLSSVGGRSAKLGQVIHHCFYKTGLIILESRLNVFGTSRPRESSKNNKWFNLEIVETELYAEQFKIWKNIELSPSRKIPPMVLHTYLDISDLSKNQTLSVSDGTHSHAINFNNMSTMKIVLERWIVNLDGEALSTPLELAVLYKKLVVLFRSLYTYTHLMPLWKLKSKIHKLRAHGTSLKVGCALSTDDVLSNDFLPISAPISSSLGSSIATFSFSPVGTPAGDFRISVQYRKNCHFEVHDSDALLSNQLLSADKHQLAASNNSQDFEDGKQYDQPPPSFATRLAKQSDPNSLLQSEIQHLASIESITAQAAPLVTIHPFKSPSLSASPGSNFDNMSISPKVAVNRYIHRGPSATSLNKFSMISDAASKSRAKLPPLTSGSLKLNTLDISNTPNLRRFSSSFGPRERKESFSSRNRLPLVNHPIRSIFKHNVSENPITDHSEHAVYDSEFASKDDLSGFIQLLDSHAHHLNASEGSKSSGSFPGKVQTLTSGISPVAHPHNSLGSSNEIFDIDTYNHSIDNSGSRFTEAVKHNLGNSSHSIMRHHTLGTLRSRPSFSEKSTFPAPLTSISQASTFQGDNRSPSTVIPHTQTEVPSANDTSKQLASLHDMRKSQSPICARSATSAGLPRFEYHTSLSKSLEHSSTPASLQATKTPSPSFVLEPGIPQEYKKHFDNLSEERRQCLTPSTPTYEYYNEHNPNYDDDLLFTMTDMTLEPHDVSAIRLGSPKSDD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 289 | Phosphorylation | DKHQLAASNNSQDFE CHHHHHHCCCCCCCC | 30.82 | 24763107 | |
| 292 | Phosphorylation | QLAASNNSQDFEDGK HHHHCCCCCCCCCCC | 35.06 | 24763107 | |
| 381 | Phosphorylation | RYIHRGPSATSLNKF HHCCCCCCCCCCCCH | 47.18 | 21712547 | |
| 383 | Phosphorylation | IHRGPSATSLNKFSM CCCCCCCCCCCCHHH | 37.78 | 21712547 | |
| 384 | Phosphorylation | HRGPSATSLNKFSMI CCCCCCCCCCCHHHH | 29.66 | 21712547 | |
| 392 | Phosphorylation | LNKFSMISDAASKSR CCCHHHHCHHHHHCC | 16.74 | 25720772 | |
| 414 | Phosphorylation | SGSLKLNTLDISNTP CCCEEECCCCCCCCC | 35.92 | 29996109 | |
| 420 | Phosphorylation | NTLDISNTPNLRRFS CCCCCCCCCCHHHHH | 13.53 | 29996109 | |
| 427 | Phosphorylation | TPNLRRFSSSFGPRE CCCHHHHHHCCCHHH | 24.22 | 25720772 | |
| 428 | Phosphorylation | PNLRRFSSSFGPRER CCHHHHHHCCCHHHH | 27.29 | 25720772 | |
| 429 | Phosphorylation | NLRRFSSSFGPRERK CHHHHHHCCCHHHHH | 32.78 | 25720772 | |
| 516 | Phosphorylation | SFPGKVQTLTSGISP CCCCCEEECCCCCCC | 34.68 | 21712547 | |
| 518 | Phosphorylation | PGKVQTLTSGISPVA CCCEEECCCCCCCCC | 28.44 | 21712547 | |
| 583 | Phosphorylation | GTLRSRPSFSEKSTF CCCCCCCCCCCCCCC | 40.05 | 29996109 | |
| 585 | Phosphorylation | LRSRPSFSEKSTFPA CCCCCCCCCCCCCCC | 48.75 | 29996109 | |
| 640 | Phosphorylation | SLHDMRKSQSPICAR HHHHHHHCCCCCHHC | 26.06 | 21712547 | |
| 642 | Phosphorylation | HDMRKSQSPICARSA HHHHHCCCCCHHCCC | 24.27 | 21712547 | |
| 648 | Phosphorylation | QSPICARSATSAGLP CCCCHHCCCCCCCCC | 19.85 | 28889911 | |
| 650 | Phosphorylation | PICARSATSAGLPRF CCHHCCCCCCCCCCE | 21.98 | 25720772 | |
| 666 | Phosphorylation | YHTSLSKSLEHSSTP EECCCCHHCCCCCCC | 35.30 | 24763107 | |
| 670 | Phosphorylation | LSKSLEHSSTPASLQ CCHHCCCCCCCHHHC | 26.91 | 24763107 | |
| 671 | Phosphorylation | SKSLEHSSTPASLQA CHHCCCCCCCHHHCC | 40.07 | 21712547 | |
| 672 | Phosphorylation | KSLEHSSTPASLQAT HHCCCCCCCHHHCCC | 26.37 | 24763107 | |
| 681 | Phosphorylation | ASLQATKTPSPSFVL HHHCCCCCCCCCCCC | 25.33 | 21712547 | |
| 683 | Phosphorylation | LQATKTPSPSFVLEP HCCCCCCCCCCCCCC | 38.11 | 21712547 | |
| 685 | Phosphorylation | ATKTPSPSFVLEPGI CCCCCCCCCCCCCCC | 32.12 | 21712547 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ATG13_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ATG13_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ATG13_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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