ACM3_HUMAN - dbPTM
ACM3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACM3_HUMAN
UniProt AC P20309
Protein Name Muscarinic acetylcholine receptor M3
Gene Name CHRM3
Organism Homo sapiens (Human).
Sequence Length 590
Subcellular Localization Cell membrane
Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane
Multi-pass membrane protein. Basolateral cell membrane
Multi-pass membrane protein.
Protein Description The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover..
Protein Sequence MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5N-linked_Glycosylation---MTLHNNSTTSPL
---CCCCCCCCCCCC		47.46UniProtKB CARBOHYD
6N-linked_Glycosylation--MTLHNNSTTSPLF
--CCCCCCCCCCCCC		29.95UniProtKB CARBOHYD
15N-linked_GlycosylationTTSPLFPNISSSWIH
CCCCCCCCCCCCCCC		39.17UniProtKB CARBOHYD
41N-linked_GlycosylationVTHFGSYNVSRAAGN
EEEEECEECCCCCCC		27.30UniProtKB CARBOHYD
48N-linked_GlycosylationNVSRAAGNFSSPDGT
ECCCCCCCCCCCCCC		28.97UniProtKB CARBOHYD
169PhosphorylationISFDRYFSITRPLTY
EECCCCCCCCCCCCH		17.7024719451
271PhosphorylationELAGLQASGTEAETE
HHHCCCCCCCCCCCC		33.0327080861
273PhosphorylationAGLQASGTEAETENF
HCCCCCCCCCCCCCC		29.5327080861
277PhosphorylationASGTEAETENFVHPT
CCCCCCCCCCCCCCC		43.1927080861
284PhosphorylationTENFVHPTGSSRSCS
CCCCCCCCCCCCCCC		34.5127080861
286PhosphorylationNFVHPTGSSRSCSSY
CCCCCCCCCCCCCHH		25.6727080861
287PhosphorylationFVHPTGSSRSCSSYE
CCCCCCCCCCCCHHH		29.5627080861
289PhosphorylationHPTGSSRSCSSYELQ
CCCCCCCCCCHHHHH		21.9427732954
291PhosphorylationTGSSRSCSSYELQQQ
CCCCCCCCHHHHHHH		36.8825884760
292PhosphorylationGSSRSCSSYELQQQS
CCCCCCCHHHHHHHH		27.2727732954
293PhosphorylationSSRSCSSYELQQQSM
CCCCCCHHHHHHHHH		12.3627732954
299PhosphorylationSYELQQQSMKRSNRR
HHHHHHHHHHHHHHC		23.1825002506
365PhosphorylationGSETRAIYSIVLKLP
CHHHHHHHEEEEECC		7.4325884760
366PhosphorylationSETRAIYSIVLKLPG
HHHHHHHEEEEECCC		10.5028152594
385PhosphorylationLNSTKLPSSDNLQVP
CCCCCCCCCCCCCCC		61.8425002506
386PhosphorylationNSTKLPSSDNLQVPE
CCCCCCCCCCCCCCH		28.6926657352
412UbiquitinationADKLQAQKSVDDGGS
HHHHHHCHHCCCCCC		56.30-
413PhosphorylationDKLQAQKSVDDGGSF
HHHHHCHHCCCCCCC		20.7823401153
419PhosphorylationKSVDDGGSFPKSFSK
HHCCCCCCCCCCHHC		43.8630177828
423PhosphorylationDGGSFPKSFSKLPIQ
CCCCCCCCHHCCCEE		34.6824719451
426UbiquitinationSFPKSFSKLPIQLES
CCCCCHHCCCEEEEH		57.16-
439UbiquitinationESAVDTAKTSDVNSS
EHHHHHCCCCCCCCC		51.13-
449UbiquitinationDVNSSVGKSTATLPL
CCCCCCCCCCCCCCC		42.34-
453PhosphorylationSVGKSTATLPLSFKE
CCCCCCCCCCCCHHH		29.0628348404
457PhosphorylationSTATLPLSFKEATLA
CCCCCCCCHHHHHHH		32.1229507054
492PhosphorylationKEKKAAQTLSAILLA
HHHHHHHHHHHHHHH		20.2524043423
494PhosphorylationKKAAQTLSAILLAFI
HHHHHHHHHHHHHHH		19.3624043423
503PhosphorylationILLAFIITWTPYNIM
HHHHHHHHHCCCHHH		20.6224043423
505PhosphorylationLAFIITWTPYNIMVL
HHHHHHHCCCHHHHH		13.7724043423
507PhosphorylationFIITWTPYNIMVLVN
HHHHHCCCHHHHHHH		15.2224043423
515PhosphorylationNIMVLVNTFCDSCIP
HHHHHHHHHCHHCCC		20.4024043423
519PhosphorylationLVNTFCDSCIPKTFW
HHHHHCHHCCCHHHH		18.3524043423
578PhosphorylationQQYQQRQSVIFHKRA
HHHHHHHHHHHCCCC		21.2626657352
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ACM3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACM3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACM3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KC1A_HUMANCSNK1A1physical
10777483
SET_HUMANSETphysical
17065150
AT1A4_HUMANATP1A4physical
28514442
TBA3C_HUMANTUBA3Cphysical
28514442
NOCT_HUMANCCRN4Lphysical
28514442
PLD2_HUMANPLD2physical
28514442
S4A7_HUMANSLC4A7physical
28514442
FARP2_HUMANFARP2physical
28514442
HEAT3_HUMANHEATR3physical
28514442
CAV1_HUMANCAV1physical
28514442
YIPF4_HUMANYIPF4physical
28514442
GTPB2_HUMANGTPBP2physical
28514442
PTH2_HUMANPTRH2physical
28514442
DCP2_HUMANDCP2physical
28514442
IPO9_HUMANIPO9physical
28514442
GBF1_HUMANGBF1physical
28514442
UBP46_HUMANUSP46physical
28514442
GPN3_HUMANGPN3physical
28514442
IPO13_HUMANIPO13physical
28514442
DYM_HUMANDYMphysical
28514442
STAR3_HUMANSTARD3physical
28514442
HOOK2_HUMANHOOK2physical
28514442
EXOC2_HUMANEXOC2physical
28514442
TBA4A_HUMANTUBA4Aphysical
28514442
ATLA2_HUMANATL2physical
28514442
FAKD1_HUMANFASTKD1physical
28514442
TTI1_HUMANTTI1physical
28514442
DNJA3_HUMANDNAJA3physical
28514442
TRM7_HUMANFTSJ1physical
28514442
CAND2_HUMANCAND2physical
28514442
TBB3_HUMANTUBB3physical
28514442
CA112_HUMANC1orf112physical
28514442
LRP10_HUMANLRP10physical
28514442
PK3CB_HUMANPIK3CBphysical
28514442
JPH1_HUMANJPH1physical
28514442
PP6R1_HUMANPPP6R1physical
28514442
LTN1_HUMANLTN1physical
28514442
TBB8_HUMANTUBB8physical
28514442
PIGX_HUMANPIGXphysical
28514442
PBIP1_HUMANPBXIP1physical
28514442
CJ035_HUMANC10orf35physical
28514442
IPO7_HUMANIPO7physical
28514442
ARL10_HUMANARL10physical
28514442
TELO2_HUMANTELO2physical
28514442
SYNM_HUMANNARS2physical
28514442
VGFR3_HUMANFLT4physical
28514442
STX18_HUMANSTX18physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
100100Prune belly syndrome (PBS)
Kegg Drug
D00113 Atropine (USP); Atropen (TN)
D00138 Scopolamine (INN); Transderm scop (TN)
D00147 Hyoscyamine (USP)
D00232 Methyloctatropine bromide (JAN); Anisotropine methylbromide (USAN); Octatropine methylbromide (INN);
D00270 Chlorpromazine (USP/INN); Thorazine (TN)
D00397 Tropicamide (JP16/USP/INN); Mydriacyl (TN)
D00465 Oxybutynin (USAN/INN); Anturol (TN); Oxytrol (TN)
D00481 Propantheline bromide (JP16/USP/INN); Pro-banthine (TN)
D00524 Carbachol (JAN/USP/INN); Miostat (TN)
D00525 Pilocarpine (JAN/USP); Ocusert pilo-20 (TN)
D00540 Glycopyrronium bromide (JAN/INN); Glycopyrrolate (USP); Robinul (TN); Seebri breezhaler (TN)
D00646 Tolterodine (USAN/INN)
D00661 Cevimeline hydrochloride hydrate (JAN); Cevimeline hydrochloride (USAN); Evoxac (TN); Saligren (TN)
D00715 Hyoscine methobromide (INN); Methscopolamine bromide; Pamine (TN)
D00719 Hyoscyamine sulfate (USP); Hyoscyamine sulfate dihydrate; Egacene (TN)
D00720 Mepenzolate bromide (JP16/INN); Cantil (TN)
D00721 Methanthelinium bromide (INN); Methantheline bromide; Banthine (TN)
D00722 Oxybutynin hydrochloride (JAN); Oxybutynin chloride (USP); Ditropan (TN); Gelnique (TN)
D00723 Tridihexethyl chloride (BAN); Pathilon (TN)
D00774 Orphenadrine citrate (USP); Norflex (TN)
D00778 Benztropine mesilate (JAN); Benztropine mesylate (USP); Cogentin (TN)
D00779 Biperiden (JAN/USP/INN); Akineton (TN)
D00782 Procyclidine hydrochloride (USP); Kemadrin (TN)
D00787 Trihexyphenidyl hydrochloride (JP16/USP); Artane (TN)
D00789 Chlorpromazine hydrochloride (JP16/USP); Sonazine (TN)
D00999 Acetylcholine chloride (JP16/USP/INN); Miochol (TN)
D01000 Bethanechol chloride (JP16/USP); Urecholine (TN)
D01002 Cyclopentolate hydrochloride (JP16/USP); Cyclogyl (TN)
D01003 Hexocyclium metilsulfate (INN); Hexocyclium methyl sulfate; Tral (TN)
D01004 Homatropine hydrobromide (JP16/USP); Isopto homatropine (TN)
D01005 Isopropamide iodide (JAN/USP/INN); Darbid (TN)
D01006 Oxyphencyclimine hydrochloride (JAN); Daricon (TN)
D01007 Propiverine hydrochloride (JP16); Bup-4 (TN); Mictonorm (TN)
D01077 Atropine methonitrate (JAN/INN); Methylatropine nitrate (USAN); Ekomine (TN)
D01103 Trospium chloride (JAN/USAN/INN); Spasmex (TN); Spasmoplex (TN)
D01118 Profenamine hydrochloride (JAN); Ethopropazine hydrochloride; Parkin (TN); Parsidol (TN)
D01148 Tolterodine tartrate (JAN/USAN); Detrol (TN); Detrusitol (TN)
D01165 Piperidolate hydrochloride (JAN); Dactil (TN)
D01175 Carpronium chloride (JAN/INN); Actinamin (TN); Furozin (TN)
D01201 Tiemonium iodide (JAN/INN); Visceralgine (TN)
D01231 Piroheptine hydrochloride (JAN); Trimol (TN)
D01269 Solifenacin succinate (JAN/USAN/INN); Vesicare (TN)
D01315 Methylbenactyzium bromide (JP16/INN)
D01359 Etomidoline (JAN/INN); Smedolin (TN)
D01377 Prifinium bromide (JAN/INN); Padrin (TN)
D01451 Scopolamine butylbromide (JP16); Butylscopolamine bromide; Buscopan (TN)
D01463 Diponium bromide (JAN/INN); Dipenine bromide
D01491 Butropium bromide (JP16/INN); Coliopan (TN)
D01500 Trimebutine maleate (JP16); Cerekinon (TN)
D01521 Pipethanate hydrochloride (JAN); Glymor (TN)
D01538 Valethamate bromide (JAN); Shinmetane (TN)
D01600 Diphenylpiperidinomethyldioxolan iodide (JAN); Anacolin; Gastrophyllin-A (TN)
D01648 Hyoscyamine methylbromide (JAN)
D01699 Darifenacin hydrobromide (JAN/USAN); Enablex (TN)
D01815 Oxapium iodide (JP16/INN); Espalexan (TN)
D01871 Metixene hydrochloride (JAN); Methixene hydrochloride (USAN); Methixene hydrochloride hydrete; Trest
D01875 Tiquizium bromide (JAN/INN); Thiaton (TN)
D01929 Tiotropium bromide hydrate (JAN); Tiotropium bromide monohydrate; Spiriva (TN)
D01946 Oxitropium bromide (JAN/INN); Tersigan (TN)
D01955 Aclatonium napadisilate (JAN); Abovis (TN)
D01976 N-Methylscopolamine methylsulfate (JAN); Daipin (TN)
D01987 Pipethanate ethobromide (JAN); Panpurol (TN)
D02069 Atropine sulfate (JP16/USP); Isopto Atropine (TN)
D02070 Homatropine methylbromide (USP); Equipin (TN)
D02071 Scopolamine hydrobromide hydrate (JP16); Scopolamine hydrobromide (USP); Scopolamine hydrobromide tr
D02200 Pilocarpine hydrochloride (JP16/USP); Isopto carpine (TN); Pilopine HS (TN); Sanpilo (TN)
D02212 Ipratropium bromide hydrate (JP16); Ipratropium bromide (USAN); Atrovent (TN)
D02246 Biperiden hydrochloride (JP16/USP); Tasmolin (TN)
D02247 Biperiden lactate (JAN/USP); Tasmolin (TN)
D02417 Flutropium bromide (JAN); Flutropium bromide monohydrate; Flubron (TN)
D02535 Timepidium bromide hydrate (JP16); Sesden (TN)
D02599 Orphenadrine hydrochloride; Disipal (TN)
D02876 Alvameline maleate (USAN)
D03011 Atropine oxide hydrochloride (USAN); Genatropine hydrochloride
D03087 Benzetimide hydrochloride (USAN); Dioxatrine (TN)
D03264 Mazaticol hydrochloride hydrate (JAN); Mazaticol hydrochloride; Pentona (TN)
D03274 Chlorpromazine hibenzate (JAN); Contomin (TN)
D03276 Profenamine hibenzate (JAN); Parkin (TN)
D03654 Darifenacin (USAN/INN)
D03711 Dexetimide (USAN/INN); (+)-Benzetimide
D03814 Atropine methylbromide (JAN)
D04034 Chlorpromazine phenolphthalinate (JAN); Wintermin (TN)
D04057 Esoxybutynin chloride (USAN)
D04087 Ethybenztropine (USAN); Etybenzatropine (INN); Panolid (TN)
D04116 Eucatropine hydrochloride (USP XXXII)
D04479 Hyoscyamine hydrobromide (USP)
D04970 Methacholine chloride (USAN/INN); Provocholine (TN)
D05035 Milameline hydrochloride (USAN)
D05478 Pilocarpine nitrate (USP); Pilagan (TN)
D05779 Sabcomeline hydrochloride (USAN)
D06015 Tazomeline citrate (USAN)
D06273 Imidafenacin (JAN/INN); Uritos (TN); Staybla (TN)
D07076 Camylofin (INN); Anafortan (TN)
D07099 Cimetropium bromide (INN); Alginor (TN)
D07226 Fesoterodine (INN)
D07349 Choline alfoscerate (INN); Gliatilin (TN)
D07406 Pimethixene (INN); Calmixene (TN)
D07477 Atropine oxide (INN); Apitropin (TN)
D07511 Benzatropine (INN); Benztropine
D07513 Benzetimide (INN); Spasmental [veterinary] (TN)
D07667 Cevimeline (INN)
D07759 Cyclopentolate (INN); Bell Pentolate (TN)
D07804 Dexetimide hydrochloride; Tremblex (TN)
D07951 Fentonium bromide (INN); Ulcesium (TN)
D08157 Mazaticol (INN)
D08209 Metixene (INN)
D08305 Orphenadrine (INN); Mialgin (TN)
D08325 Oxyphencyclimine (INN)
D08376 Pilocarpine borate; pilolarpin ophtha (TN)
D08382 Piperidolate (INN)
D08384 Pipethanate (INN); Piperilate
D08395 Piroheptine (INN)
D08425 Procyclidine (INN)
D08426 Profenamine (INN)
D08441 Propiverine (INN)
D08522 Solifenacin (INN)
D08595 Tiemonium methylsulfate; Visceralgine (TN)
D08638 Trihexyphenidyl (INN); Apo-trihex (TN)
D08639 Trimebutine (INN); Trimebutina (TN)
D08837 Aclidinium bromide (USAN/INN); Tudorza pressair (TN); Eklira genuair (TN)
D08923 Fesoterodine fumarate (JAN/USP); Toviaz (TN)
D09402 Darotropium bromide (USAN/INN)
D09752 Carpronium chloride hydrate (JAN)
D09819 Chlorpromazine tannate (JAN)
D10180 Umeclidinium (USAN)
D10181 Umeclidinium bromide (JAN/USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACM3_HUMAN

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