SYP22_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYP22_ARATH
• UniProt AC: P93654
• Protein Name: Syntaxin-22
• Gene Name: SYP22
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 268
• Subcellular Localization: Prevacuolar compartment membrane ; Single-pass type IV membrane protein . Vacuole membrane ; Single-pass type IV membrane protein . Prevacuolar compartment (PVC) in roots, and junction of two vacuolar membranes in shoot apical meristem.
• Protein Description: May provide the t-SNARE function in the vacuolar assembly. Promotes the formation of vacuolar membrane 'bulbs'. Required for inflorescence stem gravitropism..
• Protein Sequence: MSFQDLESGRGRSTRKFNGGRQDSTQAVASGIFQINTGVSTFQRLVNTLGTPKDTPELREKLHKTRLHIGQLVKDTSAKLKEASETDHQSGVNPSKKIADAKLARDFQAVLKEFQKAQQTAAERETTYTPFVPQSALPSSYTAGEVDKVPEQRAQLQESKRQELVLLDNEIAFNEAVIEEREQGIQEIHQQIGEVNEIFKDLAVLVNDQGVMIDDIGTHIDNSRAATSQGKSQLVQAAKTQKSNSSLTCLLLVIFGIVLLIVIIVLAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSFQDLESG ------CCHHHCCCC	31.45	22223895
2	Phosphorylation	------MSFQDLESG ------CCHHHCCCC	31.45	30589143
8	Phosphorylation	MSFQDLESGRGRSTR CCHHHCCCCCCCCCC	40.88	30407730
232	Phosphorylation	AATSQGKSQLVQAAK HHHHHCHHHHHHHHH	35.25	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYP22_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYP22_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYP22_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VTI12_ARATH	VTI1B	physical	15797025
CNG13_ARATH	CNGC13	physical	22737156
SNAA2_ARATH	ALPHA-SNAP2	physical	24556609
VTI11_ARATH	SGR4	physical	24556609
NSF_ARATH	NSF	physical	24556609
VA711_ARATH	VAMP711	physical	24556609
SYP51_ARATH	SYP51	physical	24556609
VCS_ARATH	VCS	physical	24556609
ENPL_ARATH	SHD	physical	24556609
SYP52_ARATH	SYP52	physical	24556609
RL191_ARATH	emb2386	physical	24556609
VAP42_ARATH	AT4G21450	physical	24556609
VAP41_ARATH	MAMI	physical	24556609
VATA_ARATH	VHA-A	physical	24556609
VA713_ARATH	VAMP713	physical	24556609
RL31_ARATH	RP1	physical	24556609
NOP5B_ARATH	AT3G05060	physical	24556609
VA721_ARATH	VAMP721	physical	24556609
RL171_ARATH	AT1G27400	physical	24556609
RS241_ARATH	AT3G04920	physical	24556609
SYP71_ARATH	SYP71	physical	24556609
HIR3_ARATH	AT3G01290	physical	24556609
ANXD4_ARATH	ANNAT4	physical	24556609
RL81_ARATH	EMB2296	physical	24556609
VA714_ARATH	VAMP714	physical	24556609
R27AA_ARATH	AT1G23410	physical	24556609
HMGB5_ARATH	HMGB5	physical	24556609
ACT12_ARATH	ACT12	physical	24556609
G3PA2_ARATH	GAPA-2	physical	24556609
JAL20_ARATH	AT2G25980	physical	24556609
RL301_ARATH	AT1G36240	physical	24556609
EXPB3_ARATH	EXPB3	physical	24556609
RS41_ARATH	AT2G17360	physical	24556609
SYP21_ARATH	SYP21	physical	24556609
IF2B_ARATH	EIF2 BETA	physical	24556609
SRP09_ARATH	AT3G49100	physical	24556609
RS232_ARATH	AT5G02960	physical	24556609
LECT2_ARATH	AT3G15356	physical	24556609

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.