dbPTM

VCS_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VCS_ARATH
UniProt AC	Q9LTT8
Protein Name	Enhancer of mRNA-decapping protein 4
Gene Name	VCS
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	1344
Subcellular Localization	Cytoplasm, P-body .
Protein Description	As a component of the decapping complex, involved in the degradation of mRNAs. Essential for postembryonic development, especially during the formation of the shoot (SAM) and root apical meristems. Required for normal patterning of internal tissues of leaves..
Protein Sequence	MASSPGNTNPHNTPPFDLGILFKPSSNPYPPPAASYPPPTGPFLHNQYDQQHYAPPGISAQPSPVTQQQQDVSSSSAATNLHPQRTLSYPTPPLNLQSPRSNHNPGTHILALLNNTNNGAPVANQEPSHQLPVVNHNEIARSFPGGSGPIRVPSCKLPKGRRLIGEHAVYDVDVRLQGEIQPQLEVTPITKYGSDPQLVVGRQIAVNKVYICYGLKGGNIRVLNINTALRSLFRGHSQRVTDMAFFAEDVDMLASVSLDGKVFVWKISEGSEGEDQPQITGKIVLALQILGEEDTKHPRVCWHCHKQEILVVSIGKHVLRIDTTKVGRGEVFSAEAPLQCPLDKLIDGVQIVGKHDGEVTDLSMCQWMTTRLVSSSVDGTIKIWQDRKAQPLVVLRPHDGHPVSSATFVTSPERPDHIILITGGPLNREMKIWVSAGEEGWLLPADAESWRCTQTLDLKSSTEPRAEEAFFNQVIALSEAGLLLLANAKRNALYAVHLDYGSSPVGTRMDYLSEFTVTMPILSFIGTNDPPEEPIVKVYCVQTLAIQQYTLDLCLCLPPPIENMGLEKSDSSVSREANLVEGMSEPSGLKPTDLPSVDSVPKPSIIVNRSESANKLSFPSAEATSQAIVPPNGEPKTSGLPSQTSGAGSAYATLPQLPLSPRLSSKLSGYHTPVEAIEPVIPHHELGGKTPSADYSVDRQMDAVGERNLDVSSVEEISRSKDSNVTPDDDVSGMRSPSAFFKHPTHLVTPSEILMGVSSAEASITTEDRRDRDANIQDVNNDPRDTEVEVKEISEARSTQNGEINDHDETENCTSENREKVFCSQVSNLSTEMARDCYPSTEGTFIPGESKAYGQPIKAGDESGVDSRGGPAKLLKGKKQKAKNSQGPGLSSTSSNVANLADSFNEQSQSLSHPMTDLLPQLLAMQETMNQVMASQKEMQRQLSNAATGPIGKESKRLEVALGRMIEKSSKSNADALWARIQEETVKNEKALRDHAQQIVNATTNFMSKELNAMFEKTIKKELAAIGPALARSVVPVIEKTVSSAITESFQRGIGDKAVNQLDKSVNIKLEATVARQIQAQFQTSGKQALQEGLRSSVESSVIPSFEKACKAMFDQIDSAFQKGIAEHTNAAQQRFDSGHSQLAHTLKESITSASSVAQALSRELAETQRNLLALAAAGANSGGSNSLVTQLSGGPLGALLEKVEAPMDPTTELSRLISERKYEESFTSALQRSDVSIVSWLCSQVDLRGLLAMNPLPLSQGVLLSLLQQLACDISKDTSRKLAWMTDVVAAINPSDQMIAVHARPIFEQVYQILHHHRNAPGSDVSAIRLIMHVINSMLMGCK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Phosphorylation	TNLHPQRTLSYPTPP CCCCCCCCCCCCCCC	18.14	24601666
88	Phosphorylation	LHPQRTLSYPTPPLN CCCCCCCCCCCCCCC	28.58	30291188
89	Phosphorylation	HPQRTLSYPTPPLNL CCCCCCCCCCCCCCC	17.78	23776212
91	Phosphorylation	QRTLSYPTPPLNLQS CCCCCCCCCCCCCCC	29.34	23776212
98	Phosphorylation	TPPLNLQSPRSNHNP CCCCCCCCCCCCCCC	26.00	30291188
142	Phosphorylation	NHNEIARSFPGGSGP CHHHHHHHCCCCCCC	27.11	29654922
147	Phosphorylation	ARSFPGGSGPIRVPS HHHCCCCCCCCCCCC	47.51	23111157
154	Phosphorylation	SGPIRVPSCKLPKGR CCCCCCCCCCCCCCC	22.49	30291188
295	Phosphorylation	QILGEEDTKHPRVCW HHHCCCCCCCCCEEC	34.24	23328941
569	Phosphorylation	ENMGLEKSDSSVSRE HHCCCCCCCCCHHHH	33.09	27531888
571	Phosphorylation	MGLEKSDSSVSREAN CCCCCCCCCHHHHHH	39.47	27531888
572	Phosphorylation	GLEKSDSSVSREANL CCCCCCCCHHHHHHH	29.15	27531888
574	Phosphorylation	EKSDSSVSREANLVE CCCCCCHHHHHHHCC	26.76	27531888
584	Phosphorylation	ANLVEGMSEPSGLKP HHHCCCCCCCCCCCC	58.15	24601666
587	Phosphorylation	VEGMSEPSGLKPTDL CCCCCCCCCCCCCCC	53.35	27288362
592	Phosphorylation	EPSGLKPTDLPSVDS CCCCCCCCCCCCCCC	48.89	27288362
596	Phosphorylation	LKPTDLPSVDSVPKP CCCCCCCCCCCCCCC	45.94	27288362
599	Phosphorylation	TDLPSVDSVPKPSII CCCCCCCCCCCCEEE	37.86	27288362
610	Phosphorylation	PSIIVNRSESANKLS CEEEEECCCCCCCCC	30.60	23776212
612	Phosphorylation	IIVNRSESANKLSFP EEEECCCCCCCCCCC	38.09	23776212
617	Phosphorylation	SESANKLSFPSAEAT CCCCCCCCCCCCCHH	36.40	23776212
620	Phosphorylation	ANKLSFPSAEATSQA CCCCCCCCCCHHCCC	36.41	23776212
624	Phosphorylation	SFPSAEATSQAIVPP CCCCCCHHCCCCCCC	16.93	23776212
625	Phosphorylation	FPSAEATSQAIVPPN CCCCCHHCCCCCCCC	25.35	23776212
637	Phosphorylation	PPNGEPKTSGLPSQT CCCCCCCCCCCCCCC	38.45	23776212
638	Phosphorylation	PNGEPKTSGLPSQTS CCCCCCCCCCCCCCC	44.45	23776212
642	Phosphorylation	PKTSGLPSQTSGAGS CCCCCCCCCCCCCCC	51.65	23776212
644	Phosphorylation	TSGLPSQTSGAGSAY CCCCCCCCCCCCCCC	33.20	23776212
645	Phosphorylation	SGLPSQTSGAGSAYA CCCCCCCCCCCCCCC	21.00	23776212
649	Phosphorylation	SQTSGAGSAYATLPQ CCCCCCCCCCCCCCC	19.99	23776212
651	Phosphorylation	TSGAGSAYATLPQLP CCCCCCCCCCCCCCC	11.21	23776212
653	Phosphorylation	GAGSAYATLPQLPLS CCCCCCCCCCCCCCC	26.71	23776212
660	Phosphorylation	TLPQLPLSPRLSSKL CCCCCCCCHHHHHHC	13.16	30291188
664	Phosphorylation	LPLSPRLSSKLSGYH CCCCHHHHHHCCCCC	27.06	23111157
665	Phosphorylation	PLSPRLSSKLSGYHT CCCHHHHHHCCCCCC	42.06	23111157
668	Phosphorylation	PRLSSKLSGYHTPVE HHHHHHCCCCCCCHH	40.83	23776212
670	Phosphorylation	LSSKLSGYHTPVEAI HHHHCCCCCCCHHHC	10.11	23776212
672	Phosphorylation	SKLSGYHTPVEAIEP HHCCCCCCCHHHCCC	22.12	23776212
690	Phosphorylation	HHELGGKTPSADYSV HHHCCCCCCCCCCCC	26.25	23776212
692	Phosphorylation	ELGGKTPSADYSVDR HCCCCCCCCCCCCHH	38.72	19880383
695	Phosphorylation	GKTPSADYSVDRQMD CCCCCCCCCCHHCHH	15.43	23776212
696	Phosphorylation	KTPSADYSVDRQMDA CCCCCCCCCHHCHHC	20.35	23776212
712	Phosphorylation	GERNLDVSSVEEISR CCCCCCCHHHHHHHC	28.47	19880383
713	Phosphorylation	ERNLDVSSVEEISRS CCCCCCHHHHHHHCC	33.14	30291188
723	Phosphorylation	EISRSKDSNVTPDDD HHHCCCCCCCCCCCC	36.62	23776212
726	Phosphorylation	RSKDSNVTPDDDVSG CCCCCCCCCCCCCCC	25.83	23776212
732	Phosphorylation	VTPDDDVSGMRSPSA CCCCCCCCCCCCCHH	33.59	27532006
734	Sulfoxidation	PDDDVSGMRSPSAFF CCCCCCCCCCCHHHH	2.74	23289948
736	Phosphorylation	DDVSGMRSPSAFFKH CCCCCCCCCHHHHCC	17.83	27532006
738	Phosphorylation	VSGMRSPSAFFKHPT CCCCCCCHHHHCCCC	38.67	27532006
798	Phosphorylation	KEISEARSTQNGEIN HHHHHHHCCCCCCCC	41.20	19880383
799	Phosphorylation	EISEARSTQNGEIND HHHHHHCCCCCCCCC	22.09	23660473
810	Phosphorylation	EINDHDETENCTSEN CCCCCCCCCCCCCCC	38.26	23660473
814	Phosphorylation	HDETENCTSENREKV CCCCCCCCCCCHHHH	51.13	23660473
815	Phosphorylation	DETENCTSENREKVF CCCCCCCCCCHHHHH	34.77	23660473
824	Phosphorylation	NREKVFCSQVSNLST CHHHHHHHHHHCCCH	23.35	23776212
827	Phosphorylation	KVFCSQVSNLSTEMA HHHHHHHHCCCHHHH	25.15	30291188
830	Phosphorylation	CSQVSNLSTEMARDC HHHHHCCCHHHHHHC	26.94	30291188
831	Phosphorylation	SQVSNLSTEMARDCY HHHHCCCHHHHHHCC	32.71	23776212
838	Phosphorylation	TEMARDCYPSTEGTF HHHHHHCCCCCCCEE	12.42	23776212
840	Phosphorylation	MARDCYPSTEGTFIP HHHHCCCCCCCEECC	16.77	23776212
841	Phosphorylation	ARDCYPSTEGTFIPG HHHCCCCCCCEECCC	33.65	23776212
844	Phosphorylation	CYPSTEGTFIPGESK CCCCCCCEECCCCCC	16.50	23776212
863	Phosphorylation	PIKAGDESGVDSRGG CCCCCCCCCCCCCCC	49.18	29654922
944	Phosphorylation	KEMQRQLSNAATGPI HHHHHHHHHHCCCCC	18.98	30589143
969	Phosphorylation	LGRMIEKSSKSNADA HHHHHHHCHHCCHHH	30.15	25561503
970	Phosphorylation	GRMIEKSSKSNADAL HHHHHHCHHCCHHHH	51.69	25561503
972	Phosphorylation	MIEKSSKSNADALWA HHHHCHHCCHHHHHH	38.92	30407730
1138	Phosphorylation	AAQQRFDSGHSQLAH HHHHHHHHHHHHHHH	35.38	19880383
1141	Phosphorylation	QRFDSGHSQLAHTLK HHHHHHHHHHHHHHH	30.34	25561503
1155	Phosphorylation	KESITSASSVAQALS HHHHHCHHHHHHHHH	25.72	27288362
1156	Phosphorylation	ESITSASSVAQALSR HHHHCHHHHHHHHHH	22.61	24808101
1182	Phosphorylation	LAAAGANSGGSNSLV HHHHCCCCCCCCCHH	43.95	27288362
1185	Phosphorylation	AGANSGGSNSLVTQL HCCCCCCCCCHHHHC	27.11	27288362
1187	Phosphorylation	ANSGGSNSLVTQLSG CCCCCCCCHHHHCCC	26.39	27288362
1190	Phosphorylation	GGSNSLVTQLSGGPL CCCCCHHHHCCCCCH	29.14	27288362
1193	Phosphorylation	NSLVTQLSGGPLGAL CCHHHHCCCCCHHHH	31.70	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VCS_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VCS_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VCS_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCP2_ARATH	DCP2	physical	17158604
DCP1_ARATH	DCP1	physical	17158604
VCS_ARATH	VCS	physical	17158604

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VCS_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Site-specific phosphorylation profiling of Arabidopsis proteins bymass spectrometry and peptide chip analysis."; de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C.,Lorkovic Z.J., Barta A., Lecourieux D., Verhounig A., Jonak C.,Hirt H.; J. Proteome Res. 7:2458-2470(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-660 AND SER-692, ANDIDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].	18433157 [Abstract]