DCP2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCP2_ARATH
• UniProt AC: Q8GW31
• Protein Name: mRNA-decapping enzyme subunit 2
• Gene Name: DCP2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 373
• Subcellular Localization: Cytoplasm, P-body . The localization to P-body is VCS-dependent.
• Protein Description: Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Essential for postembryonic development, especially during the formation of the shoot apical meristem (SAM)..
• Protein Sequence: MSGLHRSSSSSKNIGNCLPSKELLDDLCSRFVLNVPEEDQQSFERILFLVEYAYWYYEDNAVENDPKLKSLSLKEFTSLLFNSCDVLRPYVTHIDDIFKDFTSYKCRVPVTGAIILDETYERCLLVKGWKGSSWSFPRGKKSKDEEDHACAIREVLEETGFDVSKLLKREEYIEFVFRQQRVRLYIVAGVTEDTVFAPLTKKEISEITWHRLDHLQPASNEVITHGVSGLKLYMVAPFLSSLKSWILKHPSPVARRPNKPLKALCVWNARTSVGGNGTATVESQNRKSELRTTTMESNSRKPELKRTTMESHSTKPELRKGTMESHNTTATVESHNTKPVVDHSQDIKPGGSFINFKFNQSVILQALESGNSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Phosphorylation	RILFLVEYAYWYYED HHHHHHHHHHHHHHC	9.49	27545962
54	Phosphorylation	LFLVEYAYWYYEDNA HHHHHHHHHHHHCCC	7.95	27545962
56	Phosphorylation	LVEYAYWYYEDNAVE HHHHHHHHHHCCCCC	5.58	27545962
57	Phosphorylation	VEYAYWYYEDNAVEN HHHHHHHHHCCCCCC	11.58	27545962
72	Phosphorylation	DPKLKSLSLKEFTSL CHHHCCCCHHHHHHH	44.48	28011693
271	Phosphorylation	LCVWNARTSVGGNGT EEEEECCCCCCCCCC	25.92	24808101
272	Phosphorylation	CVWNARTSVGGNGTA EEEECCCCCCCCCCE	17.14	24808101

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCP2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCP2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCP2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCP5_ARATH	DCP5	physical	19855049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.