KLK11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLK11_HUMAN
• UniProt AC: Q9UBX7
• Protein Name: Kallikrein-11
• Gene Name: KLK11
• Organism: Homo sapiens (Human).
• Sequence Length: 282
• Subcellular Localization: Isoform 1: Secreted.; Isoform 2: Golgi apparatus.
• Protein Description: Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues..
• Protein Sequence: MQRLRWLRDWKSSGRGLTAAKEPGARSSPLQAMRILQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTAAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENAYPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVYTKVCKYVDWIQETMKNN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	RWLRDWKSSGRGLTA HHHHHHHHCCCCCCC	33.50	29083192
13	Phosphorylation	WLRDWKSSGRGLTAA HHHHHHHCCCCCCCC	28.87	29083192
82	Phosphorylation	TRLLCGATLIAPRWL HHHHHCCEEEHHHHH	12.18	-
131	N-linked_Glycosylation	SFPHPGFNNSLPNKD CCCCCCCCCCCCCCC	42.99	UniProtKB CARBOHYD
150	Phosphorylation	IMLVKMASPVSITWA CEEEEECCCCEEEEE	23.49	-
155	Phosphorylation	MASPVSITWAVRPLT ECCCCEEEEEECCCE	10.40	-
197	N-linked_Glycosylation	PHTLRCANITIIEHQ CHHHEECEEEEEEEE	35.25	UniProtKB CARBOHYD
213	N-linked_Glycosylation	CENAYPGNITDTMVC CCCCCCCCCCCEEEE	29.49	UniProtKB CARBOHYD
242	N-linked_Glycosylation	SGGPLVCNQSLQGII CCCCEEECCCCCCHH	27.31	UniProtKB CARBOHYD
261	Ubiquitination	DPCAITRKPGVYTKV CCCCCCCCCCHHHHH	37.16	-
270	Acetylation	GVYTKVCKYVDWIQE CHHHHHHHHHHHHHH	51.82	7824291

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLK11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLK11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLK11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBB3_HUMAN	TUBB3	physical	26186194
FAT1_HUMAN	FAT1	physical	26186194
AP3S1_HUMAN	AP3S1	physical	26186194
SPSB3_HUMAN	SPSB3	physical	26186194
LOXL2_HUMAN	LOXL2	physical	26186194
NEUR3_HUMAN	NEU3	physical	26186194
CHD1L_HUMAN	CHD1L	physical	26186194
TBA4A_HUMAN	TUBA4A	physical	26186194
TBA1A_HUMAN	TUBA1A	physical	26186194
TBL3_HUMAN	TBL3	physical	26186194
CBWD1_HUMAN	CBWD1	physical	26186194
VMP1_HUMAN	VMP1	physical	26186194
PCD20_HUMAN	PCDH20	physical	26186194
MOCOS_HUMAN	MOCOS	physical	26186194
DPOE2_HUMAN	POLE2	physical	26186194
ERAP1_HUMAN	ERAP1	physical	26186194
MANBA_HUMAN	MANBA	physical	26186194
TXD11_HUMAN	TXNDC11	physical	26186194
LCHN_HUMAN	KIAA1147	physical	26186194
CHPT1_HUMAN	CHPT1	physical	26186194
FRAS1_HUMAN	FRAS1	physical	26186194
TGBR3_HUMAN	TGFBR3	physical	26186194
GLT11_HUMAN	GALNT11	physical	26186194
RB_HUMAN	RB1	physical	26186194
WDR34_HUMAN	WDR34	physical	26186194
TIM29_HUMAN	C19orf52	physical	26186194
SPSB3_HUMAN	SPSB3	physical	28514442
TGBR3_HUMAN	TGFBR3	physical	28514442
LOXL2_HUMAN	LOXL2	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
LCHN_HUMAN	KIAA1147	physical	28514442
DPOE2_HUMAN	POLE2	physical	28514442
AP3S1_HUMAN	AP3S1	physical	28514442
MOCOS_HUMAN	MOCOS	physical	28514442
GLT11_HUMAN	GALNT11	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
CBWD1_HUMAN	CBWD1	physical	28514442
TBA1A_HUMAN	TUBA1A	physical	28514442
TIM29_HUMAN	C19orf52	physical	28514442
CHPT1_HUMAN	CHPT1	physical	28514442
MANBA_HUMAN	MANBA	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.