CAH8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAH8_HUMAN
• UniProt AC: P35219
• Protein Name: Carbonic anhydrase-related protein
• Gene Name: CA8
• Organism: Homo sapiens (Human).
• Sequence Length: 290
• Protein Description: Does not have a carbonic anhydrase catalytic activity..
• Protein Sequence: MADLSFIEDTVAFPEKEEDEEEEEEGVEWGYEEGVEWGLVFPDANGEYQSPINLNSREARYDPSLLDVRLSPNYVVCRDCEVTNDGHTIQVILKSKSVLSGGPLPQGHEFELYEVRFHWGRENQRGSEHTVNFKAFPMELHLIHWNSTLFGSIDEAVGKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRDYWVYEGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAELVEGCDGILGDNFRPTQPLSDRVIRAAFQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MADLSFIEDTVA ---CCCCCCCCCCCC	25.40	29507054
10	Phosphorylation	DLSFIEDTVAFPEKE CCCCCCCCCCCCCCC	10.84	26074081
48	Phosphorylation	FPDANGEYQSPINLN CCCCCCCEECCCCCC	18.71	-
71	Phosphorylation	SLLDVRLSPNYVVCR CCCCEEECCCEEEEE	10.67	23186163
94	Ubiquitination	HTIQVILKSKSVLSG CEEEEEEECCCCCCC	44.72	22817900
96	Ubiquitination	IQVILKSKSVLSGGP EEEEEECCCCCCCCC	42.89	21890473
196	Ubiquitination	IQYKGKSKTIPCFNP HHHCCCCCCCCCCCC	54.69	-
200	Glutathionylation	GKSKTIPCFNPNTLL CCCCCCCCCCCCCCC	4.56	22555962
258	Ubiquitination	RRLRTHVKGAELVEG HHHHHHCCHHHHCCC	44.81	-
266	Glutathionylation	GAELVEGCDGILGDN HHHHCCCCCCCCCCC	2.47	22555962

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAH8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAH8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAH8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITPR1_HUMAN	ITPR1	physical	12611586
LRCH4_HUMAN	LRCH4	physical	16169070
CRX_HUMAN	CRX	physical	25416956
TBX3_HUMAN	TBX3	physical	25416956
MAGD1_HUMAN	MAGED1	physical	25416956
GGA2_HUMAN	GGA2	physical	25416956
DHB14_HUMAN	HSD17B14	physical	25416956
SPDLY_HUMAN	SPDL1	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
KLK7_HUMAN	KLK7	physical	26186194
ALBU_HUMAN	ALB	physical	26186194
CYTM_HUMAN	CST6	physical	26186194
ITPR1_HUMAN	ITPR1	physical	26186194
ITPR2_HUMAN	ITPR2	physical	26186194
TRFE_HUMAN	TF	physical	26186194
POF1B_HUMAN	POF1B	physical	26186194
A1AT_HUMAN	SERPINA1	physical	26186194
PKP1_HUMAN	PKP1	physical	26186194
S10A7_HUMAN	S100A7	physical	26186194
PAI2_HUMAN	SERPINB2	physical	26186194
ECM1_HUMAN	ECM1	physical	26186194
IGLL5_HUMAN	IGLL5	physical	26186194
FIBG_HUMAN	FGG	physical	26186194
A1AT_HUMAN	SERPINA1	physical	28514442
KLK7_HUMAN	KLK7	physical	28514442
FIBG_HUMAN	FGG	physical	28514442
ITPR2_HUMAN	ITPR2	physical	28514442
ITPR1_HUMAN	ITPR1	physical	28514442
ALBU_HUMAN	ALB	physical	28514442
IGLL5_HUMAN	IGLL5	physical	28514442
POF1B_HUMAN	POF1B	physical	28514442
CYTM_HUMAN	CST6	physical	28514442
FETUA_HUMAN	AHSG	physical	28514442
ECM1_HUMAN	ECM1	physical	28514442
PAI2_HUMAN	SERPINB2	physical	28514442
S10A7_HUMAN	S100A7	physical	28514442
TRFE_HUMAN	TF	physical	28514442
CO3_HUMAN	C3	physical	28514442
CDSN_HUMAN	CDSN	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613227: Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00909: Zonisamide