BRL2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BRL2_ARATH
• UniProt AC: Q9ZPS9
• Protein Name: Serine/threonine-protein kinase BRI1-like 2
• Gene Name: BRL2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1143
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Receptor with a serine/threonine-protein kinase activity, which may transduce extracellular spatial and temporal signals into downstream cell differentiation responses in provascular and procambial cells. In contrast to BRI1, BRL1 and BRL3, it does not bind brassinolide..
• Protein Sequence: MTTSPIRVRIRTRIQISFIFLLTHLSQSSSSDQSSLKTDSLSLLSFKTMIQDDPNNILSNWSPRKSPCQFSGVTCLGGRVTEINLSGSGLSGIVSFNAFTSLDSLSVLKLSENFFVLNSTSLLLLPLTLTHLELSSSGLIGTLPENFFSKYSNLISITLSYNNFTGKLPNDLFLSSKKLQTLDLSYNNITGPISGLTIPLSSCVSMTYLDFSGNSISGYISDSLINCTNLKSLNLSYNNFDGQIPKSFGELKLLQSLDLSHNRLTGWIPPEIGDTCRSLQNLRLSYNNFTGVIPESLSSCSWLQSLDLSNNNISGPFPNTILRSFGSLQILLLSNNLISGDFPTSISACKSLRIADFSSNRFSGVIPPDLCPGAASLEELRLPDNLVTGEIPPAISQCSELRTIDLSLNYLNGTIPPEIGNLQKLEQFIAWYNNIAGEIPPEIGKLQNLKDLILNNNQLTGEIPPEFFNCSNIEWVSFTSNRLTGEVPKDFGILSRLAVLQLGNNNFTGEIPPELGKCTTLVWLDLNTNHLTGEIPPRLGRQPGSKALSGLLSGNTMAFVRNVGNSCKGVGGLVEFSGIRPERLLQIPSLKSCDFTRMYSGPILSLFTRYQTIEYLDLSYNQLRGKIPDEIGEMIALQVLELSHNQLSGEIPFTIGQLKNLGVFDASDNRLQGQIPESFSNLSFLVQIDLSNNELTGPIPQRGQLSTLPATQYANNPGLCGVPLPECKNGNNQLPAGTEEGKRAKHGTRAASWANSIVLGVLISAASVCILIVWAIAVRARRRDADDAKMLHSLQAVNSATTWKIEKEKEPLSINVATFQRQLRKLKFSQLIEATNGFSAASMIGHGGFGEVFKATLKDGSSVAIKKLIRLSCQGDREFMAEMETLGKIKHRNLVPLLGYCKIGEERLLVYEFMQYGSLEEVLHGPRTGEKRRILGWEERKKIAKGAAKGLCFLHHNCIPHIIHRDMKSSNVLLDQDMEARVSDFGMARLISALDTHLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSIGVVMLEILSGKRPTDKEEFGDTNLVGWSKMKAREGKHMEVIDEDLLKEGSSESLNEKEGFEGGVIVKEMLRYLEIALRCVDDFPSKRPNMLQVVASLRELRGSENNSHSHSNSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
84	N-linked_Glycosylation	GGRVTEINLSGSGLS CCEEEEEEEECCCCC	23.17	-
91	Phosphorylation	NLSGSGLSGIVSFNA EEECCCCCCEEEEEE	29.96	28011693
118	N-linked_Glycosylation	SENFFVLNSTSLLLL CCCEEEECHHHHHHH	37.63	-
163	N-linked_Glycosylation	SITLSYNNFTGKLPN EEEEECCCCCCCCCC	27.85	-
176	Phosphorylation	PNDLFLSSKKLQTLD CCCEECCCCCCCEEE	35.64	24894044
188	N-linked_Glycosylation	TLDLSYNNITGPISG EEECCCCCCCCCCCC	25.60	-
226	N-linked_Glycosylation	YISDSLINCTNLKSL CCCCHHCCCCCCCCC	31.67	-
234	N-linked_Glycosylation	CTNLKSLNLSYNNFD CCCCCCCCCEECCCC	33.75	-
288	N-linked_Glycosylation	NLRLSYNNFTGVIPE HHCCCCCCCCCCCCC	27.85	-
312	N-linked_Glycosylation	SLDLSNNNISGPFPN HCCCCCCCCCCCCCH	33.77	-
412	N-linked_Glycosylation	DLSLNYLNGTIPPEI EEEHHHHCCCCCCCC	34.89	-
469	N-linked_Glycosylation	EIPPEFFNCSNIEWV CCCHHHHCCCCEEEE	33.36	-
506	N-linked_Glycosylation	VLQLGNNNFTGEIPP EEECCCCCCCCCCCH	39.60	-
681	N-linked_Glycosylation	QIPESFSNLSFLVQI CCCCCCCCCEEEEEE	37.38	-
835	Phosphorylation	FSQLIEATNGFSAAS HHHHHHHCCCCCHHH	24.08	-
911	Phosphorylation	GEERLLVYEFMQYGS CHHHHHHEEHHHHCC	11.92	-
1001	Phosphorylation	LDTHLSVSTLAGTPG HHHCCCHHHHCCCCC	17.83	-
1002	Phosphorylation	DTHLSVSTLAGTPGY HHCCCHHHHCCCCCC	20.62	24243849
1006	Phosphorylation	SVSTLAGTPGYVPPE CHHHHCCCCCCCCHH	14.13	24243849
1009	Phosphorylation	TLAGTPGYVPPEYYQ HHCCCCCCCCHHHHH	15.81	-
1079	Phosphorylation	EDLLKEGSSESLNEK HHHHHCCCCCCCCCC	31.83	30407730
1080	Phosphorylation	DLLKEGSSESLNEKE HHHHCCCCCCCCCCC	41.90	30407730
1082	Phosphorylation	LKEGSSESLNEKEGF HHCCCCCCCCCCCCC	38.14	30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BRL2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BRL2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BRL2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAP1_ARATH	AT1G12440	physical	19000166
PPA1_ARATH	AT1G13750	physical	19000166
BRL2_ARATH	BRL2	physical	19000166
XB31_ARATH	XBAT31	physical	19000166
TTL3_ARATH	TTL3	physical	19000166
AGP26_ARATH	AGP26	physical	19000166
GDL51_ARATH	AT3G14220	physical	19000166
APG2_ARATH	AT3G16370	physical	19000166
TCTP1_ARATH	TCTP	physical	19000166
IAA7_ARATH	IAA7	physical	19000166
FK201_ARATH	AT3G55520	physical	19000166
GDI2_ARATH	GDI2	physical	19000166
RAB1C_ARATH	RABB1C	physical	19000166
GASAE_ARATH	AT5G14920	physical	19000166
GASA4_ARATH	GASA4	physical	19000166
FK119_ARATH	AT5G43190	physical	19000166
PER3_ARATH	RCI3	physical	19000166
GDL19_ARATH	AT1G54010	physical	19000166
PLA19_ARATH	AT2G19940	physical	19000166
ARGC_ARATH	AT2G19940	physical	19000166
UBQ10_ARATH	UBQ10	physical	19000166
PER42_ARATH	PRXR1	physical	19000166
PMA2_ARATH	HA2	physical	19000166
COPB2_ARATH	AT4G31490	physical	19000166
CATA2_ARATH	CAT2	physical	19000166
LRP6A_ARATH	AT5G46250	physical	19000166
GSA1_ARATH	GSA1	physical	19000166
KCS1_ARATH	KCS1	physical	19000166
RB45B_ARATH	RBP45B	physical	19000166
ERD10_ARATH	ERD10	physical	19000166
SGAT_ARATH	AGT	physical	19000166
FUCO1_ARATH	FUC1	physical	19000166
GPX2_ARATH	GPX2	physical	19000166
PER21_ARATH	AT2G37130	physical	19000166
HEVL_ARATH	PR4	physical	19000166
BGAL1_ARATH	BGAL1	physical	19000166
ACEA_ARATH	ICL	physical	19000166
B3GT4_ARATH	AT4G26940	physical	19000166
FBL15_ARATH	SLOMO	physical	19000166
SUD1_ARATH	AT4G34100	physical	19000166
BGAL3_ARATH	BGAL3	physical	19000166
CB4A_ARATH	LHCB4.1	physical	19000166
MD37E_ARATH	HSC70-1	physical	19000166
UBQ3_ARATH	UBQ3	physical	19000166
RBS3B_ARATH	AT5G38410	physical	19000166
OMT1_ARATH	OMT1	physical	19000166

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.