COPB2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COPB2_ARATH
• UniProt AC: Q9SV20
• Protein Name: Coatomer subunit beta-2
• Gene Name: At4g31490
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 948
• Subcellular Localization: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplasmic side o
• Protein Description: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity)..
• Protein Sequence: MDKSSTMLVHYDKGTPAVANEIKEALEGNDVEAKVDAMKKAIMLLLNGETIPQLFITIIRYVLPSEDHTIQKLLLLYLELIEKTDSKGKVLPEMILICQNLRNNLQHPNEYIRGVTLRFLCRMKETEIVEPLTPSVLQNLEHRHPFVRRNAILAIMSIYKLPHGDQLFVDAPEMIEKVLSTEQDPSAKRNAFLMLFTCAEERAVNYLLSNVDKVSDWNESLQMVVLELIRSVCKTKPAEKGKYIKIIISLLSATSSAVIYECAGTLVSLSSAPTAIRAAANTYCQLLLSQSDNNVKLILLDRLYELKTLHRDIMVELIIDVLRALSSPNLDIRRKTLDIALDLITHHNINEVVQMLKKEVVKTQSGELEKNGEYRQMLIQAIHACAVKFPEVASTVVHLLMDFLGDSNVASALDVVVFVREIIETNPKLRVSIITRLLDTFYQIRAGKVCPCALWIIGEYCLSLSEVESGISTITQCLGELPFYSVSEESEPTETSKKIQPTSSAMVSSRKPVILADGTYATQSAASETTFSSPTVVQGSLTSGNLRALLLTGDFFLGAVVACTLTKLVLRLEEVQSSKTEVNKTVSQALLIMVSILQLGQSPVSPHPIDNDSYERIMLCIKLLCHRNVEMKKIWLESCRQSFVKMISEKQLREMEELKAKTQTTHAQPDDLIDFFHLKSRKGMSQLELEDQVQDDLKRATGEFTKDENDANKLNRILQLTGFSDPVYAEAYVTVHHYDIALEVTVINRTKETLQNLCLELATMGDLKLVERPQNYSLAPERSMQIKANIKVSSTETGVIFGNIVYETSNVMERNVVVLNDIHIDIMDYISPAVCSEVAFRTMWAEFEWENKVAVNTTIQNEREFLDHIIKSTNMKCLTAPSAIAGECGFLAANLYAKSVFGEDALVNLSIEKQTDGTLSGYIRIRSKTQGIALSLGDKITLKQKGGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MDKSSTMLVHYDK --CCCCCCEEEECCC	22.93	19880383
206	Phosphorylation	AEERAVNYLLSNVDK HHHHHHHHHHHCCCC	11.47	17586839
209	Phosphorylation	RAVNYLLSNVDKVSD HHHHHHHHCCCCCCC	32.01	17586839
363	Phosphorylation	LKKEVVKTQSGELEK HHHHHCCCCCCCCCC	19.16	25561503
365	Phosphorylation	KEVVKTQSGELEKNG HHHCCCCCCCCCCCH	39.19	30407730
502	Phosphorylation	TSKKIQPTSSAMVSS CCCCCCCCCHHHHCC	20.95	27288362
503	Phosphorylation	SKKIQPTSSAMVSSR CCCCCCCCHHHHCCC	23.84	19880383
504	Phosphorylation	KKIQPTSSAMVSSRK CCCCCCCHHHHCCCC	23.90	19880383
508	Phosphorylation	PTSSAMVSSRKPVIL CCCHHHHCCCCCEEE	16.02	27288362
509	Phosphorylation	TSSAMVSSRKPVILA CCHHHHCCCCCEEEC	32.67	27288362
685	Phosphorylation	LKSRKGMSQLELEDQ CCCCCCCCHHCHHHH	40.04	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COPB2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COPB2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COPB2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of COPB2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.