ADA21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADA21_HUMAN
• UniProt AC: Q9UKJ8
• Protein Name: Disintegrin and metalloproteinase domain-containing protein 21
• Gene Name: ADAM21
• Organism: Homo sapiens (Human).
• Sequence Length: 722
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients..
• Protein Sequence: MAVDGTLVYIRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDDRALLEDQLFIPDDCYYHGYVEAAPESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYKINSNETQFPAMRCGLTEKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYKQLGTYIILIGIEIWNQGNVFPMTSIEQVLNDFSQWKQISLSQLQHDAAHMFIKNSLISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGERGCIMNTFRVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKRGVFLPLIVIPSLSVLTFLFTVGLLMYLRQCSGPKETKAHSSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Ubiquitination	PEVVIPLKVISRGRS CCEEEEEEEEECCCC	31.97	-
54	Phosphorylation	KVISRGRSAKAPGWL EEEECCCCCCCCCEE	36.62	46159067
64	Phosphorylation	APGWLSYSLRFGGQK CCCEEEEEEEECCEE	15.08	24719451
84	Phosphorylation	RVKKLLVSRHLPVFT EEHHHHHHCCCCCEE	17.60	24719451
164	N-linked_Glycosylation	LVYKINSNETQFPAM EEEECCCCCCCCCCC	52.42	UniProtKB CARBOHYD
176	Phosphorylation	PAMRCGLTEKEVARQ CCCCCCCCHHHHHHH	30.23	23663014
227	N-linked_Glycosylation	FFIYSQSNISKVQED EEEEECCCHHHCCCE	34.61	UniProtKB CARBOHYD
286	Phosphorylation	FSQWKQISLSQLQHD HHHHHCCCHHHHHHH	21.34	23663014
288	Phosphorylation	QWKQISLSQLQHDAA HHHCCCHHHHHHHHH	23.27	23663014
377	N-linked_Glycosylation	VPAEKFTNCSYADFM CCHHHCCCCCHHHHH	18.83	UniProtKB CARBOHYD
387	Phosphorylation	YADFMKTTLNQGSCL HHHHHHHCCCCCCCC	20.42	26503514
392	Phosphorylation	KTTLNQGSCLHNPPR HHCCCCCCCCCCCCC	12.07	26503514
437	N-linked_Glycosylation	QDACCLLNCTLRPGA HHEEEEECCCCCCCC	12.09	UniProtKB CARBOHYD
478	N-linked_Glycosylation	CDLPEWCNGTSHQCP CCCCHHHCCCCCCCC	58.83	UniProtKB CARBOHYD
546	N-linked_Glycosylation	RFGHCGINGTTYLKC CCCCCCCCCCCEEEE	27.35	UniProtKB CARBOHYD
600	N-linked_Glycosylation	IDYHLRMNISDIGEV EEEEEECCHHHCCCC	24.95	UniProtKB CARBOHYD
667	Phosphorylation	PYCQHRGYGGSIDSG CCCCCCCCCCCCCCC	20.47	29970186
673	Phosphorylation	GYGGSIDSGPASAKR CCCCCCCCCCCCCCC	45.03	29970186
677	Phosphorylation	SIDSGPASAKRGVFL CCCCCCCCCCCCCCH	37.14	68726479

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADA21_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADA21_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADA21_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCSK1_HUMAN	PCSK1N	physical	28514442
VEGFB_HUMAN	VEGFB	physical	28514442
AMGO1_HUMAN	AMIGO1	physical	28514442
1B07_HUMAN	HLA-B	physical	28514442
1B18_HUMAN	HLA-B	physical	28514442
EGFL7_HUMAN	EGFL7	physical	28514442
ITB5_HUMAN	ITGB5	physical	28514442
GBB2_HUMAN	GNB2	physical	28514442
CALX_HUMAN	CANX	physical	28514442
DYR2_HUMAN	DHFRL1	physical	28514442
PLXA2_HUMAN	PLXNA2	physical	28514442
LRRC3_HUMAN	LRRC3	physical	28514442
CCPG1_HUMAN	CCPG1	physical	28514442
LCLT1_HUMAN	LCLAT1	physical	28514442
MANF_HUMAN	MANF	physical	28514442
CHSS3_HUMAN	CHSY3	physical	28514442
ASPH2_HUMAN	ASPHD2	physical	28514442
ACTA_HUMAN	ACTA2	physical	28514442
LRFN3_HUMAN	LRFN3	physical	28514442
PLXB2_HUMAN	PLXNB2	physical	28514442
GPC4_HUMAN	GPC4	physical	28514442
ANR46_HUMAN	ANKRD46	physical	28514442
DEFM_HUMAN	PDF	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
GOGA5_HUMAN	GOLGA5	physical	28514442
LRP10_HUMAN	LRP10	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.