WDFY2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDFY2_HUMAN
• UniProt AC: Q96P53
• Protein Name: WD repeat and FYVE domain-containing protein 2
• Gene Name: WDFY2
• Organism: Homo sapiens (Human).
• Sequence Length: 400
• Subcellular Localization: Endosome . Early endosome . Cytoplasm . Localizes to intracellular vesicles (PubMed:16792529). Colocalizes with VAMP2 and PRKCZ in intracellular vesicles (PubMed:17313651). Colocalizes with AKT2 in early endosomes (By similarity).
• Protein Description: Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. [PubMed: 17313651 Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1]
• Protein Sequence: MAAEIQPKPLTRKPILLQRMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYWPSVYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMILFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQFDVETRHVFIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHEAITDEERAPTATFHDSKHNIVHVHFDATRGWLLTSGTDKVIKLWDMTPVVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
84	Phosphorylation	NPETRRLSIGLDNGT CCCCCEEEEECCCCC	16.88	27251275
232	Ubiquitination	MWDIGGRKGTAIELQ EEECCCCEEEEEEEE	64.98	-
330	Phosphorylation	GKCSSKRSSIPLMGF CCCCCCCCCCCCCCE	36.03	27251275
331	Phosphorylation	KCSSKRSSIPLMGFE CCCCCCCCCCCCCEE	32.05	27251275
383	Phosphorylation	ATRGWLLTSGTDKVI CCCCEEECCCCCCEE	23.96	-
386	Phosphorylation	GWLLTSGTDKVIKLW CEEECCCCCCEEEEE	32.20	-
388	Ubiquitination	LLTSGTDKVIKLWDM EECCCCCCEEEEEEC	45.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDFY2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDFY2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDFY2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERC6L_HUMAN	ERCC6L	physical	26186194
PALLD_HUMAN	PALLD	physical	26186194
SPF45_HUMAN	RBM17	physical	26186194
RUFY1_HUMAN	RUFY1	physical	26186194
RBM26_HUMAN	RBM26	physical	26186194
UTP6_HUMAN	UTP6	physical	26186194
GPDM_HUMAN	GPD2	physical	26186194
SR140_HUMAN	U2SURP	physical	26186194
MESD_HUMAN	MESDC2	physical	26186194
NUP54_HUMAN	NUP54	physical	26186194
NFXL1_HUMAN	NFXL1	physical	26186194
C2CD5_HUMAN	C2CD5	physical	26186194
CHERP_HUMAN	CHERP	physical	26186194
CCD51_HUMAN	CCDC51	physical	26186194
EFNB1_HUMAN	EFNB1	physical	26186194
NUP58_HUMAN	NUPL1	physical	26186194
ZBED1_HUMAN	ZBED1	physical	26186194
VAMP3_HUMAN	VAMP3	physical	26186194
TDIF1_HUMAN	DNTTIP1	physical	26186194
CTR3_HUMAN	SLC7A3	physical	26186194
MID51_HUMAN	MIEF1	physical	26186194
FIBP_HUMAN	FIBP	physical	26186194
GDIB_HUMAN	GDI2	physical	26344197
UTP6_HUMAN	UTP6	physical	28514442
TDIF1_HUMAN	DNTTIP1	physical	28514442
PALLD_HUMAN	PALLD	physical	28514442
GPDM_HUMAN	GPD2	physical	28514442
VAMP3_HUMAN	VAMP3	physical	28514442
CCD51_HUMAN	CCDC51	physical	28514442
CTR3_HUMAN	SLC7A3	physical	28514442
RUFY1_HUMAN	RUFY1	physical	28514442
ZBED1_HUMAN	ZBED1	physical	28514442
ERC6L_HUMAN	ERCC6L	physical	28514442
FIBP_HUMAN	FIBP	physical	28514442
C2CD5_HUMAN	C2CD5	physical	28514442
NUP54_HUMAN	NUP54	physical	28514442
MID51_HUMAN	MIEF1	physical	28514442
MESD_HUMAN	MESDC2	physical	28514442
NUP58_HUMAN	NUPL1	physical	28514442
CHERP_HUMAN	CHERP	physical	28514442
SR140_HUMAN	U2SURP	physical	28514442
DSN1_HUMAN	DSN1	physical	28514442
EFNB1_HUMAN	EFNB1	physical	28514442
SPF45_HUMAN	RBM17	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.