USB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: USB1_HUMAN
• UniProt AC: Q9BQ65
• Protein Name: U6 snRNA phosphodiesterase {ECO:0000255|HAMAP-Rule:MF_03040}
• Gene Name: USB1 {ECO:0000255|HAMAP-Rule:MF_03040}
• Organism: Homo sapiens (Human).
• Sequence Length: 265
• Subcellular Localization: Nucleus .
• Protein Description: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate..
• Protein Sequence: MSAAPLVGYSSSGSEDESEDGMRTRPGDGSHRRGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYEAKEEFLDLLDVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRFFFTANQVKIYTNQEKTRTFIGLEVTSGHAQFLDLVSEVDRVMEEFNLTTFYQDPSFHLSLAWCVGDARLQLEGQCLQELQAIVDGFEDAEVLLRVHTEQVRCKSGNKFFSMPLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAAPLVGY ------CCCCCCCCC		24043423
9	Phosphorylation	SAAPLVGYSSSGSED CCCCCCCCCCCCCCC		24043423
10	Phosphorylation	AAPLVGYSSSGSEDE CCCCCCCCCCCCCCC		24043423
11	Phosphorylation	APLVGYSSSGSEDES CCCCCCCCCCCCCCC		24043423
12	Phosphorylation	PLVGYSSSGSEDESE CCCCCCCCCCCCCCC		24043423
14	Phosphorylation	VGYSSSGSEDESEDG CCCCCCCCCCCCCCC		24043423
18	Phosphorylation	SSGSEDESEDGMRTR CCCCCCCCCCCCCCC		30243723
33	Methylation	PGDGSHRRGQSPLPR CCCCCCCCCCCCCCC		115919577
36	Phosphorylation	GSHRRGQSPLPRQRF CCCCCCCCCCCCCCC		30266825
169	Phosphorylation	TNQEKTRTFIGLEVT CCCCCEEEEEEEEEE		24732914
176	Phosphorylation	TFIGLEVTSGHAQFL EEEEEEEECCCHHHH		24732914
177	Phosphorylation	FIGLEVTSGHAQFLD EEEEEEECCCHHHHH		24732914
187	Phosphorylation	AQFLDLVSEVDRVME HHHHHHHHHHHHHHH		24732914
240	Acetylation	IVDGFEDAEVLLRVH HHCCCCCHHHHHHEE		19608861
258	Acetylation	VRCKSGNKFFSMPLK EEECCCCEEECCCCC		19608861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of USB1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of USB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of USB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRP19_HUMAN	PRPF19	physical	23022480
CDC5L_HUMAN	CDC5L	physical	23022480
PLRG1_HUMAN	PLRG1	physical	23022480
PPIE_HUMAN	PPIE	physical	26186194
SYF1_HUMAN	XAB2	physical	26186194
GPTC1_HUMAN	GPATCH1	physical	26186194
DHX35_HUMAN	DHX35	physical	26186194
PRP19_HUMAN	PRPF19	physical	26186194
CRNL1_HUMAN	CRNKL1	physical	26186194
BUD31_HUMAN	BUD31	physical	26186194
PLRG1_HUMAN	PLRG1	physical	26186194
CDC5L_HUMAN	CDC5L	physical	26186194
AQR_HUMAN	AQR	physical	26186194
RBM22_HUMAN	RBM22	physical	26186194
WDR83_HUMAN	WDR83	physical	26186194
SNW1_HUMAN	SNW1	physical	26186194
C19L2_HUMAN	CWF19L2	physical	26186194
ISY1_HUMAN	ISY1	physical	26186194
PRP17_HUMAN	CDC40	physical	26186194
SPF27_HUMAN	BCAS2	physical	26186194
CCD12_HUMAN	CCDC12	physical	26186194
DGC14_HUMAN	DGCR14	physical	26186194
SYF2_HUMAN	SYF2	physical	26186194
EAPP_HUMAN	EAPP	physical	26186194
SKAP_HUMAN	KNSTRN	physical	26186194
CSK21_HUMAN	CSNK2A1	physical	26186194
SNX27_HUMAN	SNX27	physical	26496610
SIM12_HUMAN	SMIM12	physical	26496610
TOM5_HUMAN	TOMM5	physical	26496610
GPTC1_HUMAN	GPATCH1	physical	28514442
DHX35_HUMAN	DHX35	physical	28514442
AQR_HUMAN	AQR	physical	28514442
CRNL1_HUMAN	CRNKL1	physical	28514442
SYF2_HUMAN	SYF2	physical	28514442
C19L2_HUMAN	CWF19L2	physical	28514442
SYF1_HUMAN	XAB2	physical	28514442
PRP17_HUMAN	CDC40	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
BUD31_HUMAN	BUD31	physical	28514442
SPF27_HUMAN	BCAS2	physical	28514442
CDC5L_HUMAN	CDC5L	physical	28514442
PPIE_HUMAN	PPIE	physical	28514442
WDR83_HUMAN	WDR83	physical	28514442
CCD12_HUMAN	CCDC12	physical	28514442
EAPP_HUMAN	EAPP	physical	28514442
PRP19_HUMAN	PRPF19	physical	28514442
SKAP_HUMAN	KNSTRN	physical	28514442
SNW1_HUMAN	SNW1	physical	28514442
RBM22_HUMAN	RBM22	physical	28514442
DGC14_HUMAN	DGCR14	physical	28514442
U520_HUMAN	SNRNP200	physical	28514442
PLRG1_HUMAN	PLRG1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 604173: Poikiloderma with neutropenia (PN)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.