dbPTM

SIM12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SIM12_HUMAN
UniProt AC	Q96EX1
Protein Name	Small integral membrane protein 12
Gene Name	SMIM12
Organism	Homo sapiens (Human).
Sequence Length	92
Subcellular Localization	Membrane Single-pass membrane protein .
Protein Description
Protein Sequence	MWPVFWTVVRTYAPYVTFPVAFVVGAVGYHLEWFIRGKDPQPVEEEKSISERREDRKLDELLGKDHTQVVSLKDKLEFAPKAVLNRNRPEKN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
48	Phosphorylation	QPVEEEKSISERRED CCHHHHHCHHHHHHH	17081983
50	Phosphorylation	VEEEKSISERREDRK HHHHHCHHHHHHHHH	28634120
58	Ubiquitination	ERREDRKLDELLGKD HHHHHHHHHHHCCCC	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SIM12_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SIM12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SIM12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
IL36A_HUMAN	IL36A	physical	28514442
VRK1_HUMAN	VRK1	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SIM12_HUMAN

Related Literatures of Post-Translational Modification