SUSD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SUSD3_HUMAN
• UniProt AC: Q96L08
• Protein Name: Sushi domain-containing protein 3
• Gene Name: SUSD3
• Organism: Homo sapiens (Human).
• Sequence Length: 255
• Subcellular Localization: Cell membrane ; Single-pass membrane protein . Prominently localized to cell-cell borders.
• Protein Description: May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration..
• Protein Sequence: MRWAAATLRGKARPRGRAGVTTPAPGNRTGTCAKLRLPPQATFQVLRGNGASVGTVLMFRCPSNHQMVGSGLLTCTWKGSIAEWSSGSPVCKLVPPHETFGFKVAVIASIVSCAIILLMSMAFLTCCLLKCVKKSKRRRSNRSAQLWSQLKDEDLETVQAAYLGLKHFNKPVSGPSQAHDNHSFTTDHGESTSKLASVTRSVDKDPGIPRALSLSGSSSSPQAQVMVHMANPRQPLPASGLATGMPQQPAAYALG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	N-linked_Glycosylation	VTTPAPGNRTGTCAK CCCCCCCCCCCCEEE	36.96	UniProtKB CARBOHYD
52	Phosphorylation	VLRGNGASVGTVLMF EECCCCCEEEEEEEE	23.60	-
55	Phosphorylation	GNGASVGTVLMFRCP CCCCEEEEEEEEECC	14.33	-
120	Phosphorylation	CAIILLMSMAFLTCC HHHHHHHHHHHHHHH	13.61	29691806
125	Phosphorylation	LMSMAFLTCCLLKCV HHHHHHHHHHHHHHH	8.50	29691806
143	Phosphorylation	KRRRSNRSAQLWSQL HHHHCCHHHHHHHHH	25.31	29970186
148	Phosphorylation	NRSAQLWSQLKDEDL CHHHHHHHHHCCCCH	33.94	30108239
151	Ubiquitination	AQLWSQLKDEDLETV HHHHHHHCCCCHHHH	51.97	-
162	Phosphorylation	LETVQAAYLGLKHFN HHHHHHHHHCHHHCC	12.34	28064214
213	Phosphorylation	PGIPRALSLSGSSSS CCCCCEEEECCCCCC	21.36	30108239
215	Phosphorylation	IPRALSLSGSSSSPQ CCCEEEECCCCCCCC	33.00	30108239
217	Phosphorylation	RALSLSGSSSSPQAQ CEEEECCCCCCCCEE	24.54	27251275
218	Phosphorylation	ALSLSGSSSSPQAQV EEEECCCCCCCCEEE	38.06	27251275
219	Phosphorylation	LSLSGSSSSPQAQVM EEECCCCCCCCEEEE	47.97	27251275
220	Phosphorylation	SLSGSSSSPQAQVMV EECCCCCCCCEEEEE	23.99	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SUSD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SUSD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SUSD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
TRI29_HUMAN	TRIM29	physical	26186194
SBSN_HUMAN	SBSN	physical	26186194
SG1D1_HUMAN	SCGB1D1	physical	26186194
CALL3_HUMAN	CALML3	physical	26186194
TYPH_HUMAN	TYMP	physical	26186194
SPB4_HUMAN	SERPINB4	physical	26186194
SPB3_HUMAN	SERPINB3	physical	26186194
S1A7A_HUMAN	S100A7A	physical	26186194
S10A7_HUMAN	S100A7	physical	26186194
PEPL_HUMAN	PPL	physical	26186194
INVO_HUMAN	IVL	physical	26186194
SG2A1_HUMAN	SCGB2A1	physical	26186194
TMM51_HUMAN	TMEM51	physical	26186194
CLC4K_HUMAN	CD207	physical	26186194
EVPL_HUMAN	EVPL	physical	26186194
IGLL5_HUMAN	IGLL5	physical	26186194
KLK10_HUMAN	KLK10	physical	26186194
S1A7A_HUMAN	S100A7A	physical	28514442
CLC4K_HUMAN	CD207	physical	28514442
KLK10_HUMAN	KLK10	physical	28514442
INVO_HUMAN	IVL	physical	28514442
TYPH_HUMAN	TYMP	physical	28514442
EVPL_HUMAN	EVPL	physical	28514442
SPB4_HUMAN	SERPINB4	physical	28514442
PEPL_HUMAN	PPL	physical	28514442
TRI29_HUMAN	TRIM29	physical	28514442
SG1D1_HUMAN	SCGB1D1	physical	28514442
SBSN_HUMAN	SBSN	physical	28514442
IGLL5_HUMAN	IGLL5	physical	28514442
CALL3_HUMAN	CALML3	physical	28514442
S10A9_HUMAN	S100A9	physical	28514442
SNX11_HUMAN	SNX11	physical	28514442
SPB3_HUMAN	SERPINB3	physical	28514442
SG2A1_HUMAN	SCGB2A1	physical	28514442
TMM51_HUMAN	TMEM51	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.