dbPTM

LPAR4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LPAR4_HUMAN
UniProt AC	Q99677
Protein Name	Lysophosphatidic acid receptor 4
Gene Name	LPAR4
Organism	Homo sapiens (Human).
Sequence Length	370
Subcellular Localization	Cell membrane Multi-pass membrane protein.
Protein Description	Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA..
Protein Sequence	MGDRRFIDFQFQDSNSSLRPRLGNATANNTCIVDDSFKYNLNGAVYSVVFILGLITNSVSLFVFCFRMKMRSETAIFITNLAVSDLLFVCTLPFKIFYNFNRHWPFGDTLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVNNATTTCFEGFSKRVWKTYLSKITIFIEVVGFIIPLILNVSCSSVVLRTLRKPATLSQIGTNKKKVLKMITVHMAVFVVCFVPYNSVLFLYALVRSQAITNCFLERFAKIMYPITLCLATLNCCFDPFIYYFTLESFQKSFYINAHIRMESLFKTETPLTTKPSLPAIQEEVSDQTTNNGGELMLESTF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	N-linked_Glycosylation	DFQFQDSNSSLRPRL EEEEECCCCCCCCCC	43.86	UniProtKB CARBOHYD
24	N-linked_Glycosylation	SLRPRLGNATANNTC CCCCCCCCCCCCCCE	38.42	UniProtKB CARBOHYD
28	N-linked_Glycosylation	RLGNATANNTCIVDD CCCCCCCCCCEEECC	39.73	UniProtKB CARBOHYD
91	Phosphorylation	SDLLFVCTLPFKIFY HHHHHHHCCCEEEEE	31.97	28060719
183	N-linked_Glycosylation	FSTTNVNNATTTCFE HCCCCCCCCCCCCCC	34.09	16335952
236	Phosphorylation	RTLRKPATLSQIGTN HHHCCCCCHHHCCCC	35.15	29083192
238	Phosphorylation	LRKPATLSQIGTNKK HCCCCCHHHCCCCHH	18.52	29083192
242	Phosphorylation	ATLSQIGTNKKKVLK CCHHHCCCCHHHHHH	45.56	25278378
332	Phosphorylation	NAHIRMESLFKTETP EEEEEHHHHCCCCCC	29.75	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LPAR4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LPAR4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LPAR4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S2535_HUMAN	SLC25A35	physical	28514442
ACD10_HUMAN	ACAD10	physical	28514442
ATLA3_HUMAN	ATL3	physical	28514442
ATM_HUMAN	ATM	physical	28514442
ARH40_HUMAN	ARHGEF40	physical	28514442
CAV1_HUMAN	CAV1	physical	28514442
TAM41_HUMAN	TAMM41	physical	28514442
SPG7_HUMAN	SPG7	physical	28514442
EFR3A_HUMAN	EFR3A	physical	28514442
PPTC7_HUMAN	PPTC7	physical	28514442
MTX1_HUMAN	MTX1	physical	28514442
RTCA_HUMAN	RTCA	physical	28514442
NLRX1_HUMAN	NLRX1	physical	28514442
2A5E_HUMAN	PPP2R5E	physical	28514442
BTAF1_HUMAN	BTAF1	physical	28514442
BIG3_HUMAN	KIAA1244	physical	28514442
RN5A_HUMAN	RNASEL	physical	28514442
POTEF_HUMAN	POTEF	physical	28514442
TIM14_HUMAN	DNAJC19	physical	28514442
AT2B2_HUMAN	ATP2B2	physical	28514442
PRKDC_HUMAN	PRKDC	physical	28514442
CAND2_HUMAN	CAND2	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442
XPO1_HUMAN	XPO1	physical	28514442
LMBD2_HUMAN	LMBRD2	physical	28514442
TTK_HUMAN	TTK	physical	28514442
PDS5B_HUMAN	PDS5B	physical	28514442
PDS5A_HUMAN	PDS5A	physical	28514442
FAKD1_HUMAN	FASTKD1	physical	28514442
FACD2_HUMAN	FANCD2	physical	28514442
BDH_HUMAN	BDH1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LPAR4_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-183, AND MASSSPECTROMETRY.	16335952 [Abstract]