S2535_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S2535_HUMAN
• UniProt AC: Q3KQZ1
• Protein Name: Solute carrier family 25 member 35
• Gene Name: SLC25A35
• Organism: Homo sapiens (Human).
• Sequence Length: 300
• Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.
• Protein Sequence: MDFLMSGLAACGACVFTNPLEVVKTRMQLQGELQAPGTYQRHYRNVFHAFITIGKVDGLAALQKGLAPALLYQFLMNGIRLGTYGLAEAGGYLHTAEGTHSPARSAAAGAMAGVMGAYLGSPIYMVKTHLQAQAASEIAVGHQYKHQGMFQALTEIGQKHGLVGLWRGALGGLPRVIVGSSTQLCTFSSTKDLLSQWEIFPPQSWKLALVAAMMSGIAVVLAMAPFDVACTRLYNQPTDAQGKGLMYRGILDALLQTARTEGIFGMYKGIGASYFRLGPHTILSLFFWDQLRSLYYTDTK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MDFLMSGLAACGA --CCCHHHHHHHCCC	32.57	20068231
17	Phosphorylation	ACGACVFTNPLEVVK HCCCEEECCCHHHHH	18.61	20068231
25	Phosphorylation	NPLEVVKTRMQLQGE CCHHHHHHHHHHCCC	21.55	20068231
38	Phosphorylation	GELQAPGTYQRHYRN CCCCCCCCHHHHHHC	18.54	20068231
39	Phosphorylation	ELQAPGTYQRHYRNV CCCCCCCHHHHHHCC	14.95	20068231
72	Phosphorylation	GLAPALLYQFLMNGI CHHHHHHHHHHHCCC	9.69	-
92	Phosphorylation	GLAEAGGYLHTAEGT CHHHCCCCEECCCCC	8.39	27080861
95	Phosphorylation	EAGGYLHTAEGTHSP HCCCCEECCCCCCCH	24.65	27080861
99	Phosphorylation	YLHTAEGTHSPARSA CEECCCCCCCHHHHH	15.64	27080861
101	Phosphorylation	HTAEGTHSPARSAAA ECCCCCCCHHHHHHH	21.79	27080861
104	Methylation	EGTHSPARSAAAGAM CCCCCHHHHHHHHHH	30.16	115386789
105	Phosphorylation	GTHSPARSAAAGAMA CCCCHHHHHHHHHHH	25.11	20873877
118	Phosphorylation	MAGVMGAYLGSPIYM HHHHHHHHHCCCEEE	13.08	20873877
121	Phosphorylation	VMGAYLGSPIYMVKT HHHHHHCCCEEEHHH	12.91	20873877
124	Phosphorylation	AYLGSPIYMVKTHLQ HHHCCCEEEHHHHHH	10.15	20873877
281	Phosphorylation	YFRLGPHTILSLFFW HHCCCHHHHHHHHHH	27.09	29507054

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S2535_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S2535_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S2535_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SC23B_HUMAN	SEC23B	physical	26186194
PMVK_HUMAN	PMVK	physical	26186194
PMVK_HUMAN	PMVK	physical	28514442
DDAH2_HUMAN	DDAH2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.