DEFI8_HUMAN - dbPTM
DEFI8_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DEFI8_HUMAN
UniProt AC Q6ZN54
Protein Name Differentially expressed in FDCP 8 homolog
Gene Name DEF8
Organism Homo sapiens (Human).
Sequence Length 512
Subcellular Localization
Protein Description Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption..
Protein Sequence MAILSLRAPGPWQAMQVWADRTLLTPHTGVTSQVLGVAAAVMTPLPGGHAAGRTREARWDAMEYDEKLARFRQAHLNPFNKQSGPRQHEQGPGEEVPDVTPEEALPELPPGEPEFRCPERVMDLGLSEDHFSRPVGLFLASDVQQLRQAIEECKQVILELPEQSEKQKDAVVRLIHLRLKLQELKDPNEDEPNIRVLLEHRFYKEKSKSVKQTCDKCNTIIWGLIQTWYTCTGCYYRCHSKCLNLISKPCVSSKVSHQAEYELNICPETGLDSQDYRCAECRAPISLRGVPSEARQCDYTGQYYCSHCHWNDLAVIPARVVHNWDFEPRKVSRCSMRYLALMVSRPVLRLREINPLLFSYVEELVEIRKLRQDILLMKPYFITCREAMEARLLLQLQDRQHFVENDEMYSVQDLLDVHAGRLGCSLTEIHTLFAKHIKLDCERCQAKGFVCELCREGDVLFPFDSHTSVCADCSAVFHRDCYYDNSTTCPKCARLSLRKQSLFQEPGPDVEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1 (in isoform 6)Acetylation-4.7622814378
1 (in isoform 2)Acetylation-4.7622814378
1 (in isoform 5)Acetylation-4.7622814378
1 (in isoform 3)Acetylation-4.7622814378
6Ubiquitination--MAILSLRAPGPWQ
--CCEEECCCCCCHH		4.9222817900
20 (in isoform 3)Ubiquitination-28.5221906983
20 (in isoform 5)Ubiquitination-28.5221906983
20 (in isoform 2)Ubiquitination-28.5221906983
20UbiquitinationQAMQVWADRTLLTPH
HHHHHHHCCCEECCC		28.5222817900
28PhosphorylationRTLLTPHTGVTSQVL
CCEECCCCCHHHHHH		34.2526503514
31PhosphorylationLTPHTGVTSQVLGVA
ECCCCCHHHHHHHHH		18.1326503514
32PhosphorylationTPHTGVTSQVLGVAA
CCCCCHHHHHHHHHE		18.8426503514
33UbiquitinationPHTGVTSQVLGVAAA
CCCCHHHHHHHHHEE		25.7021963094
40UbiquitinationQVLGVAAAVMTPLPG
HHHHHHEEECCCCCC		5.0622817900
45UbiquitinationAAAVMTPLPGGHAAG
HEEECCCCCCCCCCC		4.5322817900
45 (in isoform 4)Ubiquitination-4.5321906983
47UbiquitinationAVMTPLPGGHAAGRT
EECCCCCCCCCCCCC		48.4822817900
54UbiquitinationGGHAAGRTREARWDA
CCCCCCCCHHHHCHH		31.7622817900
54PhosphorylationGGHAAGRTREARWDA
CCCCCCCCHHHHCHH		31.76-
59 (in isoform 4)Ubiquitination-12.5521906983
59UbiquitinationGRTREARWDAMEYDE
CCCHHHHCHHHHHHH		12.5522817900
64 (in isoform 4)Ubiquitination-19.1321906983
64UbiquitinationARWDAMEYDEKLARF
HHCHHHHHHHHHHHH		19.1321963094
64PhosphorylationARWDAMEYDEKLARF
HHCHHHHHHHHHHHH		19.13-
67 (in isoform 1)Ubiquitination-44.5421906983
67UbiquitinationDAMEYDEKLARFRQA
HHHHHHHHHHHHHHH		44.5422817900
81 (in isoform 1)Ubiquitination-46.3421906983
81UbiquitinationAHLNPFNKQSGPRQH
HHCCCCCCCCCCCCC		46.3422817900
83UbiquitinationLNPFNKQSGPRQHEQ
CCCCCCCCCCCCCCC		52.9921963094
90UbiquitinationSGPRQHEQGPGEEVP
CCCCCCCCCCCCCCC		62.3527667366
93UbiquitinationRQHEQGPGEEVPDVT
CCCCCCCCCCCCCCC		50.9921963094
95UbiquitinationHEQGPGEEVPDVTPE
CCCCCCCCCCCCCHH		66.3322817900
95 (in isoform 3)Ubiquitination-66.3321906983
97UbiquitinationQGPGEEVPDVTPEEA
CCCCCCCCCCCHHHH		33.3722817900
105 (in isoform 5)Ubiquitination-3.7121906983
105UbiquitinationDVTPEEALPELPPGE
CCCHHHHCCCCCCCC		3.7122817900
105 (in isoform 2)Ubiquitination-3.7121906983
107UbiquitinationTPEEALPELPPGEPE
CHHHHCCCCCCCCCC		74.8222817900
109UbiquitinationEEALPELPPGEPEFR
HHHCCCCCCCCCCCC		32.9422817900
109 (in isoform 3)Ubiquitination-32.9421906983
114UbiquitinationELPPGEPEFRCPERV
CCCCCCCCCCCCHHH		41.2321963094
114 (in isoform 3)Ubiquitination-41.2321906983
119 (in isoform 2)Ubiquitination-62.6321906983
119 (in isoform 5)Ubiquitination-62.6321906983
119UbiquitinationEPEFRCPERVMDLGL
CCCCCCCHHHHHCCC		62.6322817900
124UbiquitinationCPERVMDLGLSEDHF
CCHHHHHCCCCCCCC		3.9221963094
124 (in isoform 2)Ubiquitination-3.9221906983
124 (in isoform 5)Ubiquitination-3.9221906983
127UbiquitinationRVMDLGLSEDHFSRP
HHHHCCCCCCCCCCC		38.9021963094
139UbiquitinationSRPVGLFLASDVQQL
CCCHHHHHHHHHHHH		5.5422817900
140UbiquitinationRPVGLFLASDVQQLR
CCHHHHHHHHHHHHH		9.0627667366
141UbiquitinationPVGLFLASDVQQLRQ
CHHHHHHHHHHHHHH		40.2222817900
150UbiquitinationVQQLRQAIEECKQVI
HHHHHHHHHHHHHHH		3.2927667366
153UbiquitinationLRQAIEECKQVILEL
HHHHHHHHHHHHHHC		2.1222817900
154UbiquitinationRQAIEECKQVILELP
HHHHHHHHHHHHHCC		51.3721963094
158UbiquitinationEECKQVILELPEQSE
HHHHHHHHHCCCCCH		6.0921963094
166UbiquitinationELPEQSEKQKDAVVR
HCCCCCHHHHHHHHH		68.8222817900
166 (in isoform 1)Ubiquitination-68.8221906983
168UbiquitinationPEQSEKQKDAVVRLI
CCCCHHHHHHHHHHH		59.7422817900
180 (in isoform 1)Ubiquitination-41.5121906983
180UbiquitinationRLIHLRLKLQELKDP
HHHHHHHHHHHHCCC		41.5122817900
184UbiquitinationLRLKLQELKDPNEDE
HHHHHHHHCCCCCCC		5.0027667366
185 (in isoform 1)Ubiquitination-71.0921906983
185UbiquitinationRLKLQELKDPNEDEP
HHHHHHHCCCCCCCC		71.0927667366
188PhosphorylationLQELKDPNEDEPNIR
HHHHCCCCCCCCCHH		78.4724719451
188 (in isoform 2)Phosphorylation-78.4724719451
207PhosphorylationHRFYKEKSKSVKQTC
HHHHHHHCHHHHHHH		31.11-
211UbiquitinationKEKSKSVKQTCDKCN
HHHCHHHHHHHHHHH		47.1627667366
378 (in isoform 4)Ubiquitination-36.2121906983
378UbiquitinationRQDILLMKPYFITCR
HHHHHHCCCEEEEHH		36.2122817900
421UbiquitinationLLDVHAGRLGCSLTE
HHHHCCCCCCCCHHH		28.7922817900
428UbiquitinationRLGCSLTEIHTLFAK
CCCCCHHHHHHHHHH		37.7622817900
428 (in isoform 3)Ubiquitination-37.7621906983
435UbiquitinationEIHTLFAKHIKLDCE
HHHHHHHHHHCCCHH		38.23-
435AcetylationEIHTLFAKHIKLDCE
HHHHHHHHHHCCCHH		38.2325825284
436UbiquitinationIHTLFAKHIKLDCER
HHHHHHHHHCCCHHH		20.9822817900
438 (in isoform 5)Ubiquitination-37.6821906983
438UbiquitinationTLFAKHIKLDCERCQ
HHHHHHHCCCHHHHH		37.6822817900
455UbiquitinationGFVCELCREGDVLFP
CCEEHHHCCCCEEEE		64.6522817900
470UbiquitinationFDSHTSVCADCSAVF
CCCCCCEECCCHHEE		2.3722817900
472UbiquitinationSHTSVCADCSAVFHR
CCCCEECCCHHEECC		23.0622817900
482UbiquitinationAVFHRDCYYDNSTTC
HEECCCCCCCCCCCC		20.3822817900
491UbiquitinationDNSTTCPKCARLSLR
CCCCCCHHHHHHHHH		42.55-
496PhosphorylationCPKCARLSLRKQSLF
CHHHHHHHHHHHHHH		22.1523532336
499UbiquitinationCARLSLRKQSLFQEP
HHHHHHHHHHHHCCC		49.9222817900
499 (in isoform 1)Ubiquitination-49.9221906983
501PhosphorylationRLSLRKQSLFQEPGP
HHHHHHHHHHCCCCC		33.9029255136
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DEFI8_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DEFI8_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DEFI8_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
WDFY3_HUMANWDFY3physical
28514442
PKN3_HUMANPKN3physical
28514442
APAF_HUMANAPAF1physical
28514442
PLCB1_HUMANPLCB1physical
28514442
RADIL_HUMANRADILphysical
28514442
HPS5_HUMANHPS5physical
28514442
KDM5C_HUMANKDM5Cphysical
28514442
MSTO1_HUMANMSTO1physical
28514442
ZMYM6_HUMANZMYM6physical
28514442
STIL_HUMANSTILphysical
28514442
MCM8_HUMANMCM8physical
28514442
CE022_HUMANC5orf22physical
28514442
TBE_HUMANTUBE1physical
28514442
VIP2_HUMANPPIP5K2physical
28514442
NRDC_HUMANNRD1physical
28514442
IF122_HUMANIFT122physical
28514442
E2AK4_HUMANEIF2AK4physical
28514442
DTL_HUMANDTLphysical
28514442
ALR_HUMANGFERphysical
28514442
PKN2_HUMANPKN2physical
28514442
DMXL2_HUMANDMXL2physical
28514442
TRIP6_HUMANTRIP6physical
28514442
DPYL4_HUMANDPYSL4physical
28514442
TBB3_HUMANTUBB3physical
28514442
DUSTY_HUMANDSTYKphysical
28514442
ALMS1_HUMANALMS1physical
28514442
ATG2B_HUMANATG2Bphysical
28514442
PASK_HUMANPASKphysical
28514442
ZNHI2_HUMANZNHIT2physical
28514442
URFB1_HUMANUHRF1BP1physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DEFI8_HUMAN

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Related Literatures of Post-Translational Modification

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