UCP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UCP2_HUMAN
• UniProt AC: P55851
• Protein Name: Mitochondrial uncoupling protein 2
• Gene Name: UCP2
• Organism: Homo sapiens (Human).
• Sequence Length: 309
• Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.
• Protein Description: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat..
• Protein Sequence: MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMAACTSREAPF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	TDVPPTATVKFLGAG CCCCCCCEEEECCCH	27.06	-
36	Phosphorylation	LITFPLDTAKVRLQI HHCCCCCCCEEEEEE	35.74	24425749
54	Phosphorylation	SQGPVRATASAQYRG CCCCEEEEEEEHHHH	15.58	29759185
56	Phosphorylation	GPVRATASAQYRGVM CCEEEEEEEHHHHCH	16.14	29759185
59	Phosphorylation	RATASAQYRGVMGTI EEEEEEHHHHCHHHH	14.73	29759185
65	Phosphorylation	QYRGVMGTILTMVRT HHHHCHHHHEEEEEC	8.50	29759185
72	Phosphorylation	TILTMVRTEGPRSLY HHEEEEECCCCHHHH	33.61	-
77	Phosphorylation	VRTEGPRSLYNGLVA EECCCCHHHHHHHHH	38.04	22496350
79	Phosphorylation	TEGPRSLYNGLVAGL CCCCHHHHHHHHHHH	14.39	24719451
94	Phosphorylation	QRQMSFASVRIGLYD HHCCCCHHHEEECHH	15.21	24719451
158	Phosphorylation	GGGRRYQSTVNAYKT CCCCCCHHHHHHHHH	25.95	-
163	Phosphorylation	YQSTVNAYKTIAREE CHHHHHHHHHHHHHH	11.94	-
165	Phosphorylation	STVNAYKTIAREEGF HHHHHHHHHHHHHCC	13.75	-
179	Phosphorylation	FRGLWKGTSPNVARN CCCCCCCCCHHHHHH	36.97	-
180	Phosphorylation	RGLWKGTSPNVARNA CCCCCCCCHHHHHHH	24.12	-
229	Phosphorylation	FGAGFCTTVIASPVD CCCCCCEEEEECCHH	15.88	-
233	Phosphorylation	FCTTVIASPVDVVKT CCEEEEECCHHHHHH	17.84	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UCP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UCP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UCP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1433B_HUMAN	YWHAB	physical	10785390
1433Z_HUMAN	YWHAZ	physical	10785390
1433T_HUMAN	YWHAQ	physical	10785390
KR107_HUMAN	KRTAP10-7	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
ANXA1_HUMAN	ANXA1	physical	26186194
ZG16B_HUMAN	ZG16B	physical	26186194
CYTS_HUMAN	CST4	physical	26186194
CYTT_HUMAN	CST2	physical	26186194
FILA_HUMAN	FLG	physical	26186194
SPB4_HUMAN	SERPINB4	physical	26186194
AL3A1_HUMAN	ALDH3A1	physical	26186194
MUC7_HUMAN	MUC7	physical	26186194
HUTH_HUMAN	HAL	physical	26186194
PIGR_HUMAN	PIGR	physical	26186194
CRNN_HUMAN	CRNN	physical	26186194
MUC7_HUMAN	MUC7	physical	28514442
CYTT_HUMAN	CST2	physical	28514442
CYTS_HUMAN	CST4	physical	28514442
CRNN_HUMAN	CRNN	physical	28514442
ZG16B_HUMAN	ZG16B	physical	28514442
PIGR_HUMAN	PIGR	physical	28514442
SPB4_HUMAN	SERPINB4	physical	28514442
SPB3_HUMAN	SERPINB3	physical	28514442
FILA_HUMAN	FLG	physical	28514442
FBX50_HUMAN	NCCRP1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.