| UniProt ID | TTLL1_HUMAN | |
|---|---|---|
| UniProt AC | O95922 | |
| Protein Name | Probable tubulin polyglutamylase TTLL1 | |
| Gene Name | TTLL1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 423 | |
| Subcellular Localization | Cytoplasm, cytoskeleton . | |
| Protein Description | Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity).. | |
| Protein Sequence | MAGKVKWVTDIEKSVLINNFEKRGWVQVTENEDWNFYWMSVQTIRNVFSVEAGYRLSDDQIVNHFPNHYELTRKDLMVKNIKRYRKELEKEGSPLAEKDENGKYLYLDFVPVTYMLPADYNLFVEEFRKSPSSTWIMKPCGKAQGKGIFLINKLSQIKKWSRDSKTSSFVSQSNKEAYVISLYINNPLLIGGRKFDLRLYVLVSTYRPLRCYMYKLGFCRFCTVKYTPSTSELDNMFVHLTNVAIQKHGEDYNHIHGGKWTVSNLRLYLESTRGKEVTSKLFDEIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDKLKPWLIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILYDEELAQGDGADRELRSRQGQSLGPRAGRSRDSGRAVLTTWK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | AGKVKWVTDIEKSVL CCCCEEECCCHHHEE | 30.09 | 27762562 | |
| 9 | O-linked_Glycosylation | AGKVKWVTDIEKSVL CCCCEEECCCHHHEE | 30.09 | 31492838 | |
| 14 | Phosphorylation | WVTDIEKSVLINNFE EECCCHHHEEEECCE | 14.90 | 27762562 | |
| 138 | Ubiquitination | PSSTWIMKPCGKAQG CCCCEEEEECCCCCC | 28.20 | - | |
| 146 | Ubiquitination | PCGKAQGKGIFLINK ECCCCCCCEEEEEEC | 36.43 | - | |
| 155 | Phosphorylation | IFLINKLSQIKKWSR EEEEECHHHHCHHCC | 31.31 | 24719451 | |
| 165 | Ubiquitination | KKWSRDSKTSSFVSQ CHHCCCCCCCCEECC | 57.63 | - | |
| 171 | Phosphorylation | SKTSSFVSQSNKEAY CCCCCEECCCCCEEE | 26.36 | - | |
| 173 | Phosphorylation | TSSFVSQSNKEAYVI CCCEECCCCCEEEEE | 42.22 | - | |
| 178 | Phosphorylation | SQSNKEAYVISLYIN CCCCCEEEEEEEEEC | 10.21 | - | |
| 181 | Phosphorylation | NKEAYVISLYINNPL CCEEEEEEEEECCCE | 12.70 | - | |
| 183 | Phosphorylation | EAYVISLYINNPLLI EEEEEEEEECCCEEE | 8.53 | - | |
| 200 | Phosphorylation | RKFDLRLYVLVSTYR EEEEEEEEEEEECCC | 5.82 | 22817900 | |
| 206 | Phosphorylation | LYVLVSTYRPLRCYM EEEEEECCCCCEEEE | 11.61 | 22817900 | |
| 212 | Phosphorylation | TYRPLRCYMYKLGFC CCCCCEEEEHHCCCC | 9.31 | 22817900 | |
| 214 | Phosphorylation | RPLRCYMYKLGFCRF CCCEEEEHHCCCCEE | 4.06 | 22817900 | |
| 268 | Phosphorylation | TVSNLRLYLESTRGK EEEEEEEEEHHCCCC | 11.29 | 20393185 | |
| 279 | Phosphorylation | TRGKEVTSKLFDEIH CCCCHHHHHHHHHHH | 32.32 | - | |
| 305 (in isoform 4) | Phosphorylation | - | 25.10 | 22210691 | |
| 306 (in isoform 4) | Phosphorylation | - | 3.65 | 22210691 | |
| 308 (in isoform 4) | Phosphorylation | - | 32.02 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TTLL1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TTLL1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TTLL1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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