SGF11_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SGF11_DROME
• UniProt AC: Q9VVR6
• Protein Name: SAGA-associated factor 11 homolog {ECO:0000255|HAMAP-Rule:MF_03047}
• Gene Name: Sgf11 {ECO:0000255|HAMAP-Rule:MF_03047}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 196
• Subcellular Localization: Nucleus, nucleoplasm . Nucleus, nuclear pore complex . Cytoplasm . Localizes to nuclear periphery, in contact with the nuclear pore complex (NPC).
• Protein Description: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Binds independently on SAGA to promoters in an RNA-dependent manner. Binds to mRNA and is essential for total mRNA export from the nucleus. Required to counteract heterochromatin silencing. Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe. Required for expression of ecdysone-induced genes such as br/broad..
• Protein Sequence: MSAANMPTTTGAQGSGNQVPTTSTTIVNHFRELIKEPKNLDEAANYLYQSLLDDAVVGIFNETHHLRKSGNLAALDGVPEDSTYRMCEMPNLDIFGISTAKKPMDCTCPNCDRLVAAARFAPHLEKCMGMGRISSRIASRRLATKEGATSAHLHSSGNTGGTDDEDDVDWSSDKRRKKSNQNSRNNGSKKNNGKTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
162	Phosphorylation	SSGNTGGTDDEDDVD CCCCCCCCCCCCCCC	41.44	22817900
172	Phosphorylation	EDDVDWSSDKRRKKS CCCCCCCHHHHHHHC	42.78	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SGF11_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SGF11_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SGF11_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ENY2B_DROME	e(y)2b	physical	14605208
RS13_DROME	RpS13	physical	14605208
NDKA_DROME	awd	physical	14605208
RLA2_DROME	RpLP2	physical	14605208
CH15_DROME	Cp15	physical	14605208
PP2A_DROME	mts	physical	14605208
GBLP_DROME	Rack1	physical	14605208
RS29_DROME	RpS29	physical	14605208
CSN2_DROME	alien	physical	14605208
TAD2B_DROME	Ada2b	physical	18188155
UBIQP_DROME	Ubi-p63E	physical	24493646
NOT_DROME	not	physical	24493646
ENY2_DROME	e(y)2	physical	24493646
TBB1_DROME	betaTub56D	physical	22989713
RAS2_DROME	Ras64B	physical	22989713
NOT_DROME	not	physical	22989713
XMAS2_DROME	xmas-2	physical	22989713
NCBP1_DROME	Cbp80	physical	22989713
HSP71_DROME	Hsp70Ab	physical	22989713
HSP70_DROME	Hsp70Ab	physical	22989713
HSP72_DROME	Hsp70Ba	physical	22989713
ENY2_DROME	e(y)2	physical	22989713
HSP75_DROME	Hsp70Bb	physical	22989713
HSP73_DROME	Hsp70Bb	physical	22989713
HSP74_DROME	Hsp70Bbb	physical	22989713

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172, AND MASSSPECTROMETRY.
PubMed: 18327897