CSN2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSN2_DROME
• UniProt AC: Q94899
• Protein Name: COP9 signalosome complex subunit 2
• Gene Name: alien {ECO:0000312|FlyBase:FBgn0013746}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 444
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis..
• Protein Sequence: MSDNDDDFMCDDDEDYGLEYSEDSNSEPDVDLENQYYNSKALKEEEPKAALASFQKVLDLENGEKGEWGFKALKQMIKINFRLCNYDEMMVRYKQLLTYIKSAVTRNHSEKSINSILDYISTSKNMALLQNFYETTLDALRDAKNDRLWFKTNTKLGKLYFDRSDFTKLQKILKQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTVQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVNSYQNNDINEFETILRQHRSNIMADQFIREHIEDLLRNIRTQVLIKLIRPYKNIAIPFIANALNIEPAEVESLLVSCILDDTIKGRIDQVNQVLQLDKINSSASRYNALEKWSNQIQSLQFAVVQKMA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Oops, there are no PTM records of CSN2_DROME !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSN2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSN2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSN2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSN2_DROME	alien	physical	10531038
ECR_DROME	EcR	physical	10207062
7UP1_DROME	svp	physical	10207062
7UP2_DROME	svp	physical	10207062
FTZF1_DROME	ftz-f1	physical	10207062
CSN6_DROME	CSN6	physical	22036573
CSN4_DROME	CSN4	physical	22036573
CSN7_DROME	CSN7	physical	22036573
PSD11_HUMAN	PSMD11	physical	12426099

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.