RPK2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPK2_ARATH
• UniProt AC: Q9S7I6
• Protein Name: LRR receptor-like serine/threonine-protein kinase RPK2
• Gene Name: RPK2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1151
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Key regulator of anther development (e.g. lignification pattern), including tapetum degradation during pollen maturation (e.g. germination capacity). Together with RPK1, required for pattern formation along the radial axis (e.g. the apical embryonic domain cell types that generate cotyledon primordia), and the apical-basal axis (e.g. differentiation of the basal pole during early embryogenesis)..
• Protein Sequence: MTSLPSSVIKWRFFRRQMPSDVVFSLCLLCFASCLAGKITVLADSDKSVLLRFKKTVSDPGSILASWVEESEDYCSWFGVSCDSSSRVMALNISGSGSSEISRNRFTCGDIGKFPLYGFGVRRDCTGNHGALAGNLPSVIMSLTGLRVLSLPFNSFSGEIPVGIWGMEKLEVLDLEGNLMTGSLPDQFTGLRNLRVMNLGFNRVSGEIPNSLQNLTKLEILNLGGNKLNGTVPGFVGRFRVLHLPLNWLQGSLPKDIGDSCGKLEHLDLSGNFLTGRIPESLGKCAGLRSLLLYMNTLEETIPLEFGSLQKLEVLDVSRNTLSGPLPVELGNCSSLSVLVLSNLYNVYEDINSVRGEADLPPGADLTSMTEDFNFYQGGIPEEITRLPKLKILWVPRATLEGRFPGDWGSCQNLEMVNLGQNFFKGEIPVGLSKCKNLRLLDLSSNRLTGELLKEISVPCMSVFDVGGNSLSGVIPDFLNNTTSHCPPVVYFDRFSIESYSDPSSVYLSFFTEKAQVGTSLIDLGSDGGPAVFHNFADNNFTGTLKSIPLAQERLGKRVSYIFSAGGNRLYGQFPGNLFDNCDELKAVYVNVSFNKLSGRIPQGLNNMCTSLKILDASVNQIFGPIPTSLGDLASLVALNLSWNQLQGQIPGSLGKKMAALTYLSIANNNLTGQIPQSFGQLHSLDVLDLSSNHLSGGIPHDFVNLKNLTVLLLNNNNLSGPIPSGFATFAVFNVSSNNLSGPVPSTNGLTKCSTVSGNPYLRPCHVFSLTTPSSDSRDSTGDSITQDYASSPVENAPSQSPGKGGFNSLEIASIASASAIVSVLIALVILFFYTRKWHPKSKIMATTKREVTMFMDIGVPITFDNVVRATGNFNASNLIGNGGFGATYKAEISQDVVVAIKRLSIGRFQGVQQFHAEIKTLGRLRHPNLVTLIGYHASETEMFLVYNYLPGGNLEKFIQERSTRDWRVLHKIALDIARALAYLHDQCVPRVLHRDVKPSNILLDDDCNAYLSDFGLARLLGTSETHATTGVAGTFGYVAPEYAMTCRVSDKADVYSYGVVLLELLSDKKALDPSFVSYGNGFNIVQWACMLLRQGRAKEFFTAGLWDAGPHDDLVEVLHLAVVCTVDSLSTRPTMKQVVRRLKQLQPPSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
92	N-linked_Glycosylation	SSRVMALNISGSGSS CCCEEEEEECCCCCC	19.49	-
214	N-linked_Glycosylation	EIPNSLQNLTKLEIL CCCCHHHHCCEEEEE	55.78	-
229	N-linked_Glycosylation	NLGGNKLNGTVPGFV ECCCCCCCCCCCCHH	45.78	-
332	N-linked_Glycosylation	PLPVELGNCSSLSVL CCCEECCCCCHHHHH	34.81	-
481	N-linked_Glycosylation	VIPDFLNNTTSHCPP CCCHHHHCCCCCCCC	47.05	-
540	N-linked_Glycosylation	FHNFADNNFTGTLKS EEECCCCCCCCCCCC	36.08	-
591	N-linked_Glycosylation	ELKAVYVNVSFNKLS HCCEEEEEEEHHHHC	13.16	-
640	N-linked_Glycosylation	LASLVALNLSWNQLQ HHHHHHHCCCHHHHC	23.45	-
670	N-linked_Glycosylation	YLSIANNNLTGQIPQ HHHHHCCCCCCCCCC	38.49	-
708	N-linked_Glycosylation	HDFVNLKNLTVLLLN CCCEECCCEEEEEEC	44.07	-
718	N-linked_Glycosylation	VLLLNNNNLSGPIPS EEEECCCCCCCCCCC	37.39	-
734	N-linked_Glycosylation	FATFAVFNVSSNNLS CEEEEEEEECCCCCC	26.60	-
739	N-linked_Glycosylation	VFNVSSNNLSGPVPS EEEECCCCCCCCCCC	37.22	-
863	Phosphorylation	MDIGVPITFDNVVRA EEECCCEEECCCEEC	20.90	-
871	Phosphorylation	FDNVVRATGNFNASN ECCCEECCCCCCHHH	23.30	-
947	Phosphorylation	ETEMFLVYNYLPGGN CCEEEEEEEECCCCC	10.55	-
983	Phosphorylation	DIARALAYLHDQCVP HHHHHHHHHHHCHHC	12.86	-
1038	Phosphorylation	GVAGTFGYVAPEYAM CCCCCCCCCCCCCCC	6.83	-
1046	Phosphorylation	VAPEYAMTCRVSDKA CCCCCCCCEECCCCH	6.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPK2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPK2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPK2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPK2_ARATH	RPK2	physical	20978082
FEI1_ARATH	FEI1	physical	21423366
Y5410_ARATH	AT5G24100	physical	21423366
AMT12_ARATH	AMT1;2	physical	21423366
ACA12_ARATH	AT3G63380	physical	21423366
Y4245_ARATH	AT4G20450	physical	21423366
BLUS1_ARATH	AT4G14480	physical	21423366
SBIR1_ARATH	SOBIR1	physical	21423366
Y3804_ARATH	AT3G28040	physical	21423366
MLO2_ARATH	MLO2	physical	21423366
Y5129_ARATH	AT5G10290	physical	21423366
Y5838_ARATH	BIR1	physical	21423366
Y2289_ARATH	AT2G28960	physical	21423366
Y5639_ARATH	AT5G63930	physical	21423366
LUT1_ARATH	LUT1	physical	24833385
MSBP1_ARATH	MSBP1	physical	24833385
HHP2_ARATH	HHP2	physical	24833385
HHP4_ARATH	HHP4	physical	24833385
UBC32_ARATH	UBC32	physical	24833385
UBC34_ARATH	UBC34	physical	24833385
KSG4_ARATH	SK42	physical	24833385
ACBP6_ARATH	ACBP6	physical	24833385
TRXH3_ARATH	TRX3	physical	24833385
LPAT2_ARATH	LPAT2	physical	24833385
CNIH1_ARATH	AT3G12180	physical	24833385
HSDD3_ARATH	AT2G43420	physical	24833385
MSBP2_ARATH	MAPR3	physical	24833385
CP21D_ARATH	AT3G66654	physical	24833385

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.