dbPTM

MLO2_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MLO2_ARATH
UniProt AC	Q9SXB6
Protein Name	MLO-like protein 2
Gene Name	MLO2
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	573
Subcellular Localization	Membrane Multi-pass membrane protein.
Protein Description	May be involved in modulation of pathogen defense and leaf cell death. Activity seems to be regulated by Ca(2+)-dependent calmodulin binding and seems not to require heterotrimeric G proteins (By similarity)..
Protein Sequence	MADQVKERTLEETSTWAVAVVCFVLLFISIVLEHSIHKIGTWFKKKHKQALFEALEKVKAELMLLGFISLLLTIGQTPISNICISQKVASTMHPCSAAEEAKKYGKKDAGKKDDGDGDKPGRRLLLELAESYIHRRSLATKGYDKCAEKGKVAFVSAYGIHQLHIFIFVLAVVHVVYCIVTYAFGKIKMRTWKSWEEETKTIEYQYSNDPERFRFARDTSFGRRHLNFWSKTRVTLWIVCFFRQFFGSVTKVDYLALRHGFIMAHFAPGNESRFDFRKYIQRSLEKDFKTVVEISPVIWFVAVLFLLTNSYGLRSYLWLPFIPLVVILIVGTKLEVIITKLGLRIQEKGDVVRGAPVVQPGDDLFWFGKPRFILFLIHLVLFTNAFQLAFFAWSTYEFNLNNCFHESTADVVIRLVVGAVVQILCSYVTLPLYALVTQMGSKMKPTVFNDRVATALKKWHHTAKNETKHGRHSGSNTPFSSRPTTPTHGSSPIHLLHNFNNRSVENYPSSPSPRYSGHGHHEHQFWDPESQHQEAETSTHHSLAHESSEPVLASVELPPIRTSKSLRDFSFKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
207	Phosphorylation	KTIEYQYSNDPERFR CEEEEECCCCHHHHH	21.16	30407730
473	Phosphorylation	ETKHGRHSGSNTPFS CCCCCCCCCCCCCCC	42.42	29654922
475	Phosphorylation	KHGRHSGSNTPFSSR CCCCCCCCCCCCCCC	40.31	25561503
477	Phosphorylation	GRHSGSNTPFSSRPT CCCCCCCCCCCCCCC	27.66	29654922
503	Phosphorylation	LHNFNNRSVENYPSS EECCCCCCCCCCCCC	35.59	23776212
507	Phosphorylation	NNRSVENYPSSPSPR CCCCCCCCCCCCCCC	7.32	23776212
509	Phosphorylation	RSVENYPSSPSPRYS CCCCCCCCCCCCCCC	44.51	23776212
510	Phosphorylation	SVENYPSSPSPRYSG CCCCCCCCCCCCCCC	25.54	27532006
512	Phosphorylation	ENYPSSPSPRYSGHG CCCCCCCCCCCCCCC	24.77	30291188
565	Phosphorylation	PPIRTSKSLRDFSFK CCCCCCCCHHCCCCC	28.53	25561503
570	Phosphorylation	SKSLRDFSFKK---- CCCHHCCCCCC----	40.21	23111157

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MLO2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MLO2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MLO2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
GCR1_ARATH	GCR1	physical	21423366

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MLO2_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509; SER-510 ANDSER-512, AND MASS SPECTROMETRY.	19376835 [Abstract]