PCDAA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCDAA_HUMAN
• UniProt AC: Q9Y5I2
• Protein Name: Protocadherin alpha-10
• Gene Name: PCDHA10
• Organism: Homo sapiens (Human).
• Sequence Length: 948
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted .
• Protein Description: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
• Protein Sequence: MVSRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDNAPALLASPAGSAGGAVSELVLRSVVAGHVVAKVRAVDADSGYNAWLSYELQSAAVGARIPFRVGLYTGEISTTRALDETDSPRQRLLVLVKDHGEPSLTATATVLVSLVEGSQAPKASSRASVGVAPEVALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAAPTEGACGPVKPTLVCSSAVGSWSYSQQRRQRVCSGEGLPKADLMAFSPSLPPCPMVDVDGEDQSIGGDHSRKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
256	N-linked_Glycosylation	KMYENQVNQTLVIRL EEEECCCCCEEEEEE	21.25	UniProtKB CARBOHYD
264	N-linked_Glycosylation	QTLVIRLNASDSDEG CEEEEEECCCCCCCC	27.78	UniProtKB CARBOHYD
513	Phosphorylation	YVSVHAESGKVYALQ EEEEEECCCCEEEEC	44.70	-
547	N-linked_Glycosylation	GVPPLGSNLTLQVFV CCCCCCCCEEEEEEE	34.93	UniProtKB CARBOHYD
583	Phosphorylation	VSELVLRSVVAGHVV HHHHHHHHHHHCCEE	19.45	24719451
600	Phosphorylation	VRAVDADSGYNAWLS EEEEECCCCCCEEEE	44.92	18187866
602	Phosphorylation	AVDADSGYNAWLSYE EEECCCCCCEEEEHH	12.98	-
612	Ubiquitination	WLSYELQSAAVGARI EEEHHHHHCCCCCCC	30.71	33845483
628	Phosphorylation	FRVGLYTGEISTTRA EEEEEECCCCCCCEE	19.38	32142685
745	Phosphorylation	VCSSAVGSWSYSQQR EEECCCCCCCHHHHH	13.27	22210691
747	Phosphorylation	SSAVGSWSYSQQRRQ ECCCCCCCHHHHHHH	19.32	22210691
748	Phosphorylation	SAVGSWSYSQQRRQR CCCCCCCHHHHHHHH	12.30	28857561
749	Phosphorylation	AVGSWSYSQQRRQRV CCCCCCHHHHHHHHH	17.83	28857561
806	Phosphorylation	QPNPDWRYSASLRAG CCCCCCCCEEHHHCC	12.34	-
807	Phosphorylation	PNPDWRYSASLRAGM CCCCCCCEEHHHCCC	11.65	24719451
809	Phosphorylation	PDWRYSASLRAGMHS CCCCCEEHHHCCCCC	16.67	24719451
816	Phosphorylation	SLRAGMHSSVHLEEA HHHCCCCCCEEHHHC	25.76	28857561
817	Phosphorylation	LRAGMHSSVHLEEAG HHCCCCCCEEHHHCC	10.01	24719451
875	Ubiquitination	KYGPGNPKQSGPGEL ECCCCCCCCCCCCCC	62.18	33845483
891	Phosphorylation	DKFIIPGSPAIISIR CCEEECCCCEEEEEE	13.05	27050516
896	Phosphorylation	PGSPAIISIRQEPTN CCCCEEEEEECCCCC	12.95	27732954
902	Phosphorylation	ISIRQEPTNSQIDKS EEEECCCCCCCCCHH	46.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCDAA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCDAA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCDAA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCDA6_HUMAN	PCDHA6	physical	28514442
PCDA2_HUMAN	PCDHA2	physical	28514442
PCDC1_HUMAN	PCDHAC1	physical	28514442
PCDA5_HUMAN	PCDHA5	physical	28514442
PCDA4_HUMAN	PCDHA4	physical	28514442
PCDA8_HUMAN	PCDHA8	physical	28514442
PCDAC_HUMAN	PCDHA12	physical	28514442
PCDA3_HUMAN	PCDHA3	physical	28514442
PCDAD_HUMAN	PCDHA13	physical	28514442
PCDA9_HUMAN	PCDHA9	physical	28514442
PCDAB_HUMAN	PCDHA11	physical	28514442
PCDA7_HUMAN	PCDHA7	physical	28514442
DCMC_HUMAN	MLYCD	physical	28514442
RL23_HUMAN	RPL23	physical	28514442
VWA1_HUMAN	VWA1	physical	28514442
AGAP1_HUMAN	AGAP1	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
SAMD1_HUMAN	SAMD1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.