| UniProt ID | PCDA8_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y5H6 | |
| Protein Name | Protocadherin alpha-8 | |
| Gene Name | PCDHA8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 950 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. |
|
| Protein Description | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.. | |
| Protein Sequence | MDYHWRGELGSWRLLLLLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFMLDVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRQSAGVLGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSALPTEGGCRAGKPTLVCSSAVGSWSYSQQQPQRVCSGEGPPKTDLMAFSPCLPPDLGSVDVGEEQDLNVDHGLKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 33 | Phosphorylation | VGSGQLHYSVPEEAK HCCCCCCCCCCHHHC | 21.69 | - | |
| 257 | N-linked_Glycosylation | RIFENADNGTTVIKL EEEECCCCCCEEEEE | 47.50 | UniProtKB CARBOHYD | |
| 265 | N-linked_Glycosylation | GTTVIKLNASDPDEG CCEEEEEECCCCCCC | 32.18 | UniProtKB CARBOHYD | |
| 356 | Phosphorylation | EIALTSLSLPVREDA EEEEEECCCCHHCCC | 30.32 | 24945436 | |
| 432 | Phosphorylation | VTARDGGSPSLWATA EEECCCCCCCEEEEE | 19.49 | - | |
| 512 | Phosphorylation | SSYISVHTESGKVYA HCEEEEEECCCCEEE | 29.68 | - | |
| 514 | Phosphorylation | YISVHTESGKVYALQ EEEEEECCCCEEEEC | 45.10 | - | |
| 548 | N-linked_Glycosylation | GVPPLGSNVTLQVFV CCCCCCCCEEEEEEE | 29.06 | UniProtKB CARBOHYD | |
| 578 | Phosphorylation | GGTGGAASKLVPRSV CCCCCHHHHCCCCCC | 26.45 | 23186163 | |
| 601 | Phosphorylation | VRAVDADSGYNAWLS EEEEECCCCCCEEEE | 44.92 | 18187866 | |
| 603 | Phosphorylation | AVDADSGYNAWLSYE EEECCCCCCEEEEEE | 12.98 | 22817900 | |
| 660 | Phosphorylation | DHGEPALTATATVLV CCCCCCCEEEEEEHH | 24.86 | - | |
| 662 | Phosphorylation | GEPALTATATVLVSL CCCCCEEEEEEHHHH | 20.02 | - | |
| 664 | Phosphorylation | PALTATATVLVSLVE CCCEEEEEEHHHHHH | 15.26 | - | |
| 679 | Phosphorylation | SGQAPKASSRQSAGV CCCCCCCCCCCCCCC | 31.98 | - | |
| 680 | Phosphorylation | GQAPKASSRQSAGVL CCCCCCCCCCCCCCC | 38.92 | - | |
| 760 | Phosphorylation | QQPQRVCSGEGPPKT CCCCCCCCCCCCCCC | 36.70 | 28348404 | |
| 767 | Phosphorylation | SGEGPPKTDLMAFSP CCCCCCCCCEEEECC | 39.89 | - | |
| 800 | Phosphorylation | VDHGLKPRQPNPDWR CCCCCCCCCCCCCCC | 64.10 | 24719451 | |
| 808 | Phosphorylation | QPNPDWRYSASLRAG CCCCCCCCEEEHHCC | 12.34 | - | |
| 809 | Phosphorylation | PNPDWRYSASLRAGM CCCCCCCEEEHHCCC | 11.65 | 24719451 | |
| 811 | Phosphorylation | PDWRYSASLRAGMHS CCCCCEEEHHCCCCC | 16.67 | 24719451 | |
| 818 | Phosphorylation | SLRAGMHSSVHLEEA EHHCCCCCCEEHHHC | 25.76 | 28857561 | |
| 819 | Phosphorylation | LRAGMHSSVHLEEAG HHCCCCCCEEHHHCC | 10.01 | 24719451 | |
| 877 | Ubiquitination | KYGPGNPKQSGPGEL ECCCCCCCCCCCCCC | 62.18 | 33845483 | |
| 893 | Phosphorylation | DKFIIPGSPAIISIR CCEEECCCCEEEEEE | 13.05 | 27050516 | |
| 898 | Phosphorylation | PGSPAIISIRQEPTN CCCCEEEEEECCCCC | 12.95 | 27732954 | |
| 904 | Phosphorylation | ISIRQEPTNSQIDKS EEEECCCCCCCCCHH | 46.91 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCDA8_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCDA8_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCDA8_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PCDA8_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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