PCDC1_HUMAN - dbPTM
PCDC1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCDC1_HUMAN
UniProt AC Q9H158
Protein Name Protocadherin alpha-C1
Gene Name PCDHAC1
Organism Homo sapiens (Human).
Sequence Length 963
Subcellular Localization Cell membrane
Single-pass type I membrane protein.
Protein Description Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
Protein Sequence MVGCGVAVLCLWVSCGAAAGQLEYSVPEETERGVAVGNLSADLRLPAAAMSSRNFRFLSSHRELYFGVDLPSGNLVVREPADREQLCRAKAACVLTYDLVLEDPLELHKIRIHVLDTNDNSPLFPAGDVQLHIPEFLTPGARFTLPNAQDDDEGSNGILSYSLSPSQHFRLDMGSRVDGSEYPELVLEKALDREQRATHLLVLTARDGGLPARSGDAQVTIIVVDTNDNAPVFERSVYRTKVPETAPNGTVLFRVQALDPDEGSNGEVQYSLSNSTQAELRHRFHVHPKSGEVQVAASLGPPETLLEAYIEARDEGVFGLASTAKLLVEVTDVNDHAPELDFLTLSNPVPEDAAPGTVIALFSVKDEDLDSNGRVICGMSSAGPFQLTASFDNYYSLLIDGPLDREQISEYQVLITASDSGSPPLSTRRTITVSVADVNDNTPNFPQPQQELFVAENNGPGASLGRVFAQDPDLGKNGLVSYELLDVISEGPSASSLLAVESSSGAITAKTSFDFEQLRGFHFQVEGRDGGIPPRSATVTINLFVVDRNDNYPVILFPLPRNGSVPVEIVPRSARTGHLVTKVVAEDADSGSNAWLSYHISRASDSSLFRISANIGELRTARLVLPTDAVKQRVVVVVRDHGDPPLSSSVTLGVLLSNSVPQLLPDFEDVWEPGGQLSAQNLYLVIALACISFLFLGCLLFFVCTKLHQSPGCCAQSCCRSTEDLRYGSKMVSNPCMTSATIDVTTVERLSQTYLYRASLGLGSDNNSLLLRGEYNAADLRNLATGVGLNLPISCIQIRNRKGDHANVNAMPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
38N-linked_GlycosylationERGVAVGNLSADLRL
CCCEEEECCCCCCCC		24.99UniProtKB CARBOHYD
204PhosphorylationATHLLVLTARDGGLP
HCEEEEEEECCCCCC		16.5024719451
248N-linked_GlycosylationKVPETAPNGTVLFRV
CCCCCCCCCEEEEEE		57.19UniProtKB CARBOHYD
274N-linked_GlycosylationEVQYSLSNSTQAELR
EEEEEECCCCCCHHH		55.13UniProtKB CARBOHYD
290PhosphorylationRFHVHPKSGEVQVAA
HEEECCCCCCEEEEH		44.6428176443
298PhosphorylationGEVQVAASLGPPETL
CCEEEEHHCCCCHHH		24.9128176443
304PhosphorylationASLGPPETLLEAYIE
HHCCCCHHHHHHHHH		42.2828176443
309PhosphorylationPETLLEAYIEARDEG
CHHHHHHHHHHHHCC		7.0128176443
322PhosphorylationEGVFGLASTAKLLVE
CCCCCCCHHEEEEEE		33.6628176443
323PhosphorylationGVFGLASTAKLLVEV
CCCCCCHHEEEEEEE		23.3928176443
325AcetylationFGLASTAKLLVEVTD
CCCCHHEEEEEEEEC		42.3022361619
562N-linked_GlycosylationILFPLPRNGSVPVEI
EEEECCCCCCCCEEE		45.19UniProtKB CARBOHYD
564PhosphorylationFPLPRNGSVPVEIVP
EECCCCCCCCEEEEC		27.1422617229
573PhosphorylationPVEIVPRSARTGHLV
CEEEECCCCCCCCCE		18.9422617229
581PhosphorylationARTGHLVTKVVAEDA
CCCCCCEEEEEEECC		25.2024719451
607PhosphorylationISRASDSSLFRISAN
HHHCCCCCCEEEEEC		36.2024719451
733PhosphorylationRYGSKMVSNPCMTSA
CCCCEECCCCCCCCC		31.4022468782
741PhosphorylationNPCMTSATIDVTTVE
CCCCCCCEEEEHHHH		19.9222468782
751PhosphorylationVTTVERLSQTYLYRA
EHHHHHHHHEEEEEE		27.0530257219
759PhosphorylationQTYLYRASLGLGSDN
HEEEEEEECCCCCCC		17.6124719451
775PhosphorylationSLLLRGEYNAADLRN
CEEECEECCHHHHHH		16.9624719451
821PhosphorylationQPNPDWRYSASLRAG
CCCCCCCCEEEHHCC		12.34-
822PhosphorylationPNPDWRYSASLRAGM
CCCCCCCEEEHHCCC		11.6524719451
824PhosphorylationPDWRYSASLRAGMHS
CCCCCEEEHHCCCCC		16.6724719451
831PhosphorylationSLRAGMHSSVHLEEA
EHHCCCCCCEEHHHC		25.7628857561
832PhosphorylationLRAGMHSSVHLEEAG
HHCCCCCCEEHHHCC		10.0124719451
906PhosphorylationDKFIIPGSPAIISIR
CCEEECCCCEEEEEE		13.0527050516
911PhosphorylationPGSPAIISIRQEPTN
CCCCEEEEEECCCCC		12.9527732954
917PhosphorylationISIRQEPTNSQIDKS
EEEECCCCCCCCCHH		46.91-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCDC1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCDC1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCDC1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DJC18_HUMANDNAJC18physical
28514442
ABCB9_HUMANABCB9physical
28514442
C2C2L_HUMANC2CD2Lphysical
28514442
CA043_HUMANC1orf43physical
28514442
AVR2A_HUMANACVR2Aphysical
28514442
CISD2_HUMANCISD2physical
28514442
ATF6A_HUMANATF6physical
28514442
RL23_HUMANRPL23physical
28514442
TYW1_HUMANTYW1physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PCDC1_HUMAN

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Related Literatures of Post-Translational Modification

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