| UniProt ID | PCDA5_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y5H7 | |
| Protein Name | Protocadherin alpha-5 | |
| Gene Name | PCDHA5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 936 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. |
|
| Protein Description | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.. | |
| Protein Sequence | MVYSRRGSLGSRLLLLWLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFRVGLYTGEISTTRSLDETEAPRHRLLVLVKDHGEPPLTATATVLVSLVESGQAPKASSRASAGAVGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAQPTEAVCTRGKPTLLCSSAVGSWSYSQQRRQRVCSGEAPPKTDLMAFSPSLPQGPTSTDNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MVYSRRGSLGSRLLL CCCCCCCCHHHHHHH | 27.96 | - | |
| 11 | Phosphorylation | SRRGSLGSRLLLLWL CCCCCHHHHHHHHHH | 25.66 | - | |
| 170 | Dimethylation | ANAQLRYRLNPNEYF CCCEEEEECCCCCCE | 22.89 | - | |
| 170 | Methylation | ANAQLRYRLNPNEYF CCCEEEEECCCCCCE | 22.89 | 24412135 | |
| 196 | Methylation | NFLELVLRKSLDREE CHHHHHHHHCCCHHH | 21.02 | 24412143 | |
| 196 | Dimethylation | NFLELVLRKSLDREE CHHHHHHHHCCCHHH | 21.02 | - | |
| 264 | N-linked_Glycosylation | GTLVIKLNASDADEG CEEEEEECCCCCCCC | 32.18 | UniProtKB CARBOHYD | |
| 431 | Phosphorylation | VTARDGGSPSLWATA EEECCCCCCCEEEEE | 19.49 | - | |
| 504 | Phosphorylation | RVGERPLSSYVSVHA CCCCCCCCCEEEEEE | 23.47 | 24719451 | |
| 505 | Phosphorylation | VGERPLSSYVSVHAE CCCCCCCCEEEEEEC | 36.92 | 27251275 | |
| 506 | Phosphorylation | GERPLSSYVSVHAES CCCCCCCEEEEEECC | 8.05 | 24719451 | |
| 508 | Phosphorylation | RPLSSYVSVHAESGK CCCCCEEEEEECCCC | 10.43 | 27251275 | |
| 513 | Phosphorylation | YVSVHAESGKVYALQ EEEEEECCCCEEEEC | 44.70 | 27251275 | |
| 547 | N-linked_Glycosylation | GVPPLGSNVTLQVFV CCCCCCCCEEEEEEE | 29.06 | UniProtKB CARBOHYD | |
| 678 | Phosphorylation | SGQAPKASSRASAGA CCCCCCCCCCCCCCC | 26.87 | - | |
| 679 | Phosphorylation | GQAPKASSRASAGAV CCCCCCCCCCCCCCC | 36.40 | - | |
| 746 | Phosphorylation | LCSSAVGSWSYSQQR EECCCCCCCCHHHHH | 13.27 | 28857561 | |
| 749 | Phosphorylation | SAVGSWSYSQQRRQR CCCCCCCHHHHHHHH | 12.30 | 28857561 | |
| 750 | Phosphorylation | AVGSWSYSQQRRQRV CCCCCCHHHHHHHHH | 17.83 | 28857561 | |
| 794 | Phosphorylation | QPNPDWRYSASLRAG CCCCCCCCEEHHHCC | 12.34 | - | |
| 795 | Phosphorylation | PNPDWRYSASLRAGM CCCCCCCEEHHHCCC | 11.65 | 24719451 | |
| 797 | Phosphorylation | PDWRYSASLRAGMHS CCCCCEEHHHCCCCC | 16.67 | 24719451 | |
| 804 | Phosphorylation | SLRAGMHSSVHLEEA HHHCCCCCCEEHHHC | 25.76 | 28857561 | |
| 805 | Phosphorylation | LRAGMHSSVHLEEAG HHCCCCCCEEHHHCC | 10.01 | 24719451 | |
| 863 | Ubiquitination | KYGPGNPKQSGPGEL ECCCCCCCCCCCCCC | 62.18 | 33845483 | |
| 873 (in isoform 3) | Phosphorylation | - | 36.20 | 24043423 | |
| 876 (in isoform 3) | Phosphorylation | - | 3.39 | 24043423 | |
| 879 | Phosphorylation | DKFIIPGSPAIISIR CCEEECCCCEEEEEE | 13.05 | 27050516 | |
| 884 | Phosphorylation | PGSPAIISIRQEPTN CCCCEEEEEECCCCC | 12.95 | 27732954 | |
| 890 | Phosphorylation | ISIRQEPTNSQIDKS EEEECCCCCCCCCHH | 46.91 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCDA5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCDA5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCDA5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PCDA5_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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