IFN21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IFN21_HUMAN
• UniProt AC: P01568
• Protein Name: Interferon alpha-21
• Gene Name: IFNA21
• Organism: Homo sapiens (Human).
• Sequence Length: 189
• Subcellular Localization: Secreted.
• Protein Description: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase..
• Protein Sequence: MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISPFSCLKDRHDFGFPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTKDSSATWEQSLLEKFSTELNQQLNDLEACVIQEVGVEETPLMNVDSILAVKKYFQRITLYLTEKKYSPCAWEVVRAEIMRSFSLSKIFQERLRRKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	LAQMGRISPFSCLKD HHHCCCCCCCHHCCC	20.66	29514088
51	Phosphorylation	MGRISPFSCLKDRHD CCCCCCCHHCCCCCC	23.17	29514088
103	Phosphorylation	SSATWEQSLLEKFST CCCHHHHHHHHHHHH	24.33	24719451
155	Phosphorylation	QRITLYLTEKKYSPC HHHHHHHCCCCCCCC	32.00	21964256
176	Phosphorylation	AEIMRSFSLSKIFQE HHHHHHCCHHHHHHH	32.74	24719451
178	Phosphorylation	IMRSFSLSKIFQERL HHHHCCHHHHHHHHH	23.62	24719451
179	Sumoylation	MRSFSLSKIFQERLR HHHCCHHHHHHHHHH	53.48	-
179	Sumoylation	MRSFSLSKIFQERLR HHHCCHHHHHHHHHH	53.48	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IFN21_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IFN21_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IFN21_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IFNA4_HUMAN	IFNA4	physical	28514442
IFNA6_HUMAN	IFNA6	physical	28514442
ISG15_HUMAN	ISG15	physical	28514442
UBR3_HUMAN	UBR3	physical	28514442
IFI44_HUMAN	IFI44	physical	28514442
IF44L_HUMAN	IFI44L	physical	28514442
IFIT1_HUMAN	IFIT1	physical	28514442
IFN14_HUMAN	IFNA14	physical	28514442
PCYXL_HUMAN	PCYOX1L	physical	28514442
IFIT3_HUMAN	IFIT3	physical	28514442
EMC3_HUMAN	EMC3	physical	28514442
CD109_HUMAN	CD109	physical	28514442
CCHL_HUMAN	HCCS	physical	28514442
EMC4_HUMAN	EMC4	physical	28514442
LRFN1_HUMAN	LRFN1	physical	28514442
NDST2_HUMAN	NDST2	physical	28514442
EMC7_HUMAN	EMC7	physical	28514442
MSRB3_HUMAN	MSRB3	physical	28514442
SUMF1_HUMAN	SUMF1	physical	28514442
CO4A2_HUMAN	COL4A2	physical	28514442
ATS1_HUMAN	ADAMTS1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.