IER2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IER2_HUMAN
• UniProt AC: Q9BTL4
• Protein Name: Immediate early response gene 2 protein
• Gene Name: IER2 {ECO:0000312|HGNC:HGNC:28871}
• Organism: Homo sapiens (Human).
• Sequence Length: 223
• Subcellular Localization: Cytoplasm . Nucleus . Cytoplasmic during quiescence, translocates to the nucleus upon stimulation.
• Protein Description: DNA-binding protein that seems to act as a transcription factor. [PubMed: 19584537 Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity Promotes cell motility, seems to stimulate tumor metastasis]
• Protein Sequence: MEVQKEAQRIMTLSVWKMYHSRMQRGGLRLHRSLQLSLVMRSARELYLSAKVEALEPEVSLPAALPSDPRLHPPREAESTAETATPDGEHPFPEPMDTQEAPTAEETSACCAPRPAKVSRKRRSSSLSDGGDAGLVPSKKARLEEKEEEEGASSEVADRLQPPPAQAEGAFPNLARVLQRRFSGLLNCSPAAPPTAPPACEAKPACRPADSMLNVLVRAVVAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEVQKEAQ -------CHHHHHHH	11.68	22814378
5	Ubiquitination	---MEVQKEAQRIMT ---CHHHHHHHHHHH	61.26	-
33	Phosphorylation	GGLRLHRSLQLSLVM HCCHHHHHHHHHHHH	15.10	22210691
37	Phosphorylation	LHRSLQLSLVMRSAR HHHHHHHHHHHHHHH	13.12	22210691
51	Ubiquitination	RELYLSAKVEALEPE HHHHHHCEEEECCCC	36.91	21906983
60	Phosphorylation	EALEPEVSLPAALPS EECCCCCCCCCCCCC	27.29	-
98	Phosphorylation	PFPEPMDTQEAPTAE CCCCCCCCCCCCCHH	23.27	22210691
103	Phosphorylation	MDTQEAPTAEETSAC CCCCCCCCHHHHCCC	54.47	22210691
107	Phosphorylation	EAPTAEETSACCAPR CCCCHHHHCCCCCCC	17.09	22210691
108	Phosphorylation	APTAEETSACCAPRP CCCHHHHCCCCCCCC	23.69	22210691
124	Phosphorylation	KVSRKRRSSSLSDGG CCCCCHHCCCCCCCC	28.45	29496963
125	Phosphorylation	VSRKRRSSSLSDGGD CCCCHHCCCCCCCCC	33.22	25159151
126	Phosphorylation	SRKRRSSSLSDGGDA CCCHHCCCCCCCCCC	32.89	21815630
128	Phosphorylation	KRRSSSLSDGGDAGL CHHCCCCCCCCCCCC	35.84	24114839
146	Ubiquitination	KKARLEEKEEEEGAS HHHHHHHHHHHCCCC	62.14	21906983
183	Phosphorylation	RVLQRRFSGLLNCSP HHHHHHHHCCCCCCC	27.07	28348404
189	Phosphorylation	FSGLLNCSPAAPPTA HHCCCCCCCCCCCCC	19.25	28348404
195	Phosphorylation	CSPAAPPTAPPACEA CCCCCCCCCCCCCCC	51.22	23312004
203	Ubiquitination	APPACEAKPACRPAD CCCCCCCCCCCCCHH	15.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IER2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IER2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IER2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBT40_HUMAN	ZBTB40	physical	26186194
RBP2_HUMAN	RANBP2	physical	26186194
RGPD8_HUMAN	RGPD8	physical	26186194
IMA3_HUMAN	KPNA4	physical	26186194
IMA4_HUMAN	KPNA3	physical	26186194
2AAB_HUMAN	PPP2R1B	physical	26186194
2AAA_HUMAN	PPP2R1A	physical	26186194
2ABD_HUMAN	PPP2R2D	physical	26186194
2ABA_HUMAN	PPP2R2A	physical	26186194
HDGR2_HUMAN	HDGFRP2	physical	26186194
GANP_HUMAN	MCM3AP	physical	26186194
BRCA2_HUMAN	BRCA2	physical	26186194
NU153_HUMAN	NUP153	physical	26186194
GLE1_HUMAN	GLE1	physical	26186194
CDCA2_HUMAN	CDCA2	physical	26186194
BRE1B_HUMAN	RNF40	physical	26186194
PITX2_HUMAN	PITX2	physical	26186194
KDM5C_HUMAN	KDM5C	physical	26186194
UTRO_HUMAN	UTRN	physical	26186194
ZC11A_HUMAN	ZC3H11A	physical	26186194
GALC_HUMAN	GALC	physical	26186194
P73_HUMAN	TP73	physical	26186194
NSE4A_HUMAN	NSMCE4A	physical	26186194
SGO2_HUMAN	SGOL2	physical	26186194
TRI27_HUMAN	TRIM27	physical	26186194
MDM2_HUMAN	MDM2	physical	26186194
ZBT40_HUMAN	ZBTB40	physical	28514442
IMA3_HUMAN	KPNA4	physical	28514442
CDCA2_HUMAN	CDCA2	physical	28514442
2AAB_HUMAN	PPP2R1B	physical	28514442
SGO2_HUMAN	SGOL2	physical	28514442
GLE1_HUMAN	GLE1	physical	28514442
PITX2_HUMAN	PITX2	physical	28514442
RGPD8_HUMAN	RGPD8	physical	28514442
NSE4A_HUMAN	NSMCE4A	physical	28514442
P73_HUMAN	TP73	physical	28514442
KDM5C_HUMAN	KDM5C	physical	28514442
2AAA_HUMAN	PPP2R1A	physical	28514442
IMA4_HUMAN	KPNA3	physical	28514442
GANP_HUMAN	MCM3AP	physical	28514442
2ABA_HUMAN	PPP2R2A	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
ZC11A_HUMAN	ZC3H11A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.