GPX7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPX7_HUMAN
• UniProt AC: Q96SL4
• Protein Name: Glutathione peroxidase 7
• Gene Name: GPX7
• Organism: Homo sapiens (Human).
• Sequence Length: 187
• Subcellular Localization: Secreted .
• Protein Description: It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks..
• Protein Sequence: MVAATVAAAWLLLWAAACAQQEQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQHYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAVTGTGAHPAFKYLAQTSGKEPTWNFWKYLVAPDGKVVGAWDPTVSVEEVRPQITALVRKLILLKREDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
111	Phosphorylation	ARRTYSVSFPMFSKI HHHHEEEECCCCCEE	20.07	22210691
123	Phosphorylation	SKIAVTGTGAHPAFK CEEECCCCCCCHHHH	23.10	22210691
136	Phosphorylation	FKYLAQTSGKEPTWN HHHHHHCCCCCCCCC	35.47	22210691
147	Phosphorylation	PTWNFWKYLVAPDGK CCCCHHEEEECCCCC	9.30	-
162	Phosphorylation	VVGAWDPTVSVEEVR EEEEECCCCCHHHHH	23.96	-
164	Phosphorylation	GAWDPTVSVEEVRPQ EEECCCCCHHHHHHH	26.70	-
173	Phosphorylation	EEVRPQITALVRKLI HHHHHHHHHHHHHHH	14.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPX7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPX7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPX7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SGTA_HUMAN	SGTA	physical	16189514
GRP78_HUMAN	HSPA5	physical	23123197
GRP75_HUMAN	HSPA9	physical	23123197
PDIA4_HUMAN	PDIA4	physical	23123197
EF1A1_HUMAN	EEF1A1	physical	23123197
DJB11_HUMAN	DNAJB11	physical	23123197
H15_HUMAN	HIST1H1B	physical	23123197
CEP70_HUMAN	CEP70	physical	25416956
PDIA1_HUMAN	P4HB	physical	23919619
UTP6_HUMAN	UTP6	physical	28514442
GAK_HUMAN	GAK	physical	28514442
PLPHP_HUMAN	PROSC	physical	28514442
NFS1_HUMAN	NFS1	physical	28514442
NIPA_HUMAN	ZC3HC1	physical	28514442
LYRM4_HUMAN	LYRM4	physical	28514442
THYN1_HUMAN	THYN1	physical	28514442
SESQ1_HUMAN	FAM109A	physical	28514442
THNS1_HUMAN	THNSL1	physical	28514442
RIPK1_HUMAN	RIPK1	physical	28514442
MCTS1_HUMAN	MCTS1	physical	28514442
FTO_HUMAN	FTO	physical	28514442
PKHJ1_HUMAN	PLEKHJ1	physical	28514442
CHM1A_HUMAN	CHMP1A	physical	28514442
PTN11_HUMAN	PTPN11	physical	28514442
HSP7E_HUMAN	HSPA14	physical	28514442
SNX1_HUMAN	SNX1	physical	28514442
CA052_HUMAN	C1orf52	physical	28514442
SH3G1_HUMAN	SH3GL1	physical	28514442
PAPS1_HUMAN	PAPSS1	physical	28514442
SYFB_HUMAN	FARSB	physical	28514442
PSME1_HUMAN	PSME1	physical	28514442
S23IP_HUMAN	SEC23IP	physical	28514442
E2AK2_HUMAN	EIF2AK2	physical	28514442
ZG16B_HUMAN	ZG16B	physical	28514442
ZCCHL_HUMAN	ZC3HAV1L	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.