DDB1A_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDB1A_ARATH
• UniProt AC: Q9M0V3
• Protein Name: DNA damage-binding protein 1a
• Gene Name: DDB1A
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1088
• Subcellular Localization: Cytoplasm . Nucleus . Translocates to the nucleus upon exposure to UV.
• Protein Description: Component of light signal transduction machinery. Involved in repression of photomorphogenesis in darkness by participating in the CDD complex, a complex probably required to regulate the activity of ubiquitin conjugating enzymes (E2s). Repression of photomorphogenesis is probably mediated by ubiquitination and subsequent degradation of photomorphogenesis-promoting factors such as HY5, HYH and LAF1. Plays a role in DNA repair by forming with DDB2 the UV-damaged DNA-binding protein complex (UV-DDB). Component of the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin-protein ligase complex..
• Protein Sequence: MSSWNYVVTAHKPTSVTHSCVGNFTSPQELNLIVAKCTRIEIHLLTPQGLQPMLDVPIYGRIATLELFRPHGEAQDFLFIATERYKFCVLQWDPESSELITRAMGDVSDRIGRPTDNGQIGIIDPDCRLIGLHLYDGLFKVIPFDNKGQLKEAFNIRLEELQVLDIKFLFGCAKPTIAVLYQDNKDARHVKTYEVSLKDKDFVEGPWSQNSLDNGADLLIPVPPPLCGVLIIGEETIVYCSASAFKAIPIRPSITKAYGRVDVDGSRYLLGDHAGMIHLLVITHEKEKVTGLKIELLGETSIASTISYLDNAVVFVGSSYGDSQLVKLNLHPDAKGSYVEVLERYINLGPIVDFCVVDLERQGQGQVVTCSGAFKDGSLRVVRNGIGINEQASVELQGIKGMWSLKSSIDEAFDTFLVVSFISETRILAMNLEDELEETEIEGFLSQVQTLFCHDAVYNQLVQVTSNSVRLVSSTTRELRDEWHAPAGFTVNVATANASQVLLATGGGHLVYLEIGDGKLTEVQHALLEYEVSCLDINPIGDNPNYSQLAAVGMWTDISVRIFSLPELTLITKEQLGGEIIPRSVLLCAFEGISYLLCALGDGHLLNFQMDTTTGQLKDRKKVSLGTQPITLRTFSSKSATHVFAASDRPTVIYSSNKKLLYSNVNLKEVSHMCPFNSAAFPDSLAIAREGELTIGTIDDIQKLHIRTIPLGEHARRICHQEQTRTFGICSLGNQSNSEESEMHFVRLLDDQTFEFMSTYPLDSFEYGCSILSCSFTEDKNVYYCVGTAYVLPEENEPTKGRILVFIVEDGRLQLIAEKETKGAVYSLNAFNGKLLAAINQKIQLYKWMLRDDGTRELQSECGHHGHILALYVQTRGDFIVVGDLMKSISLLLYKHEEGAIEERARDYNANWMSAVEILDDDIYLGAENNFNLLTVKKNSEGATDEERGRLEVVGEYHLGEFVNRFRHGSLVMRLPDSEIGQIPTVIFGTVNGVIGVIASLPQEQYTFLEKLQSSLRKVIKGVGGLSHEQWRSFNNEKRTAEARNFLDGDLIESFLDLSRNKMEDISKSMNVQVEELCKRVEELTRLH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
821	Phosphorylation	QLIAEKETKGAVYSL EEEEEECCCCCEEEE	45.93	19880383
894	Phosphorylation	KSISLLLYKHEEGAI HHHHHHHHHCCCCCH	15.40	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDB1A_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDB1A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDB1A_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COP10_ARATH	FUS9	physical	16844902
CUL4_ARATH	CUL4	physical	16844902
CUL4_ARATH	CUL4	physical	16792691
DET1_ARATH	DET1	physical	16792691
DDB2_ARATH	DDB2	physical	16792691
THOC6_ARATH	DWA1	physical	18223036
MSI3_ARATH	MSI3	physical	18223036
RAE1_ARATH	AT1G80670	physical	18223036
EIF3I_ARATH	TRIP-1	physical	18223036
GBB_ARATH	AGB1	physical	18223036
FY_ARATH	FY	physical	18223036
PRL1_ARATH	PRL1	physical	18223036
CUL4_ARATH	CUL4	physical	18223036
SPA1_ARATH	SPA1	physical	20061554
COP1_ARATH	COP1	physical	20061554
SPA2_ARATH	SPA2	physical	20061554
SPA3_ARATH	SPA3	physical	20061554
SPA4_ARATH	SPA4	physical	20061554
THOC6_ARATH	DWA1	physical	20525848
DWA2_ARATH	DWA2	physical	20525848
CUL4_ARATH	CUL4	physical	20525848
MSI1_ARATH	MSI1	physical	21240189
DDB2_ARATH	DDB2	physical	21240189
CUL4_ARATH	CUL4	physical	21421380
MSI4_ARATH	FVE	physical	21282611
CLF_ARATH	CLF	physical	21282611
DCAF1_ARATH	DCAF1	physical	18552200
DET1_ARATH	DET1	physical	24563205

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.