dbPTM

DDB2_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DDB2_ARATH
UniProt AC	Q6NQ88
Protein Name	Protein DAMAGED DNA-BINDING 2
Gene Name	DDB2
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	557
Subcellular Localization	Nucleus . Broadly distributed over chromatin.
Protein Description	May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex including DDB1A and CUL4 (By similarity). Required for DNA repair. Binds to DDB1A to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. [PubMed: 18551167 Involved in UV-B tolerance and genome integrity. In association with ATCSA-1, is necessary for repair of UV-B-induced DNA lesions]
Protein Sequence	MSSTRSRRKRDPEIVIARDTDSELSSSEEEEEEEDNYPFSESEEEDEAVKNGGKIELEKNKAKGKAPITVKLIKKVCKVCKQPGHEAGFKGATYIDCPMKPCFLCKMPGHTTMSCPHRVVTDHGILPTSHRNTKNPIDFVFKRQLQPRIPPIKPKYVIPDQVHCAVIRYHSRRVTCLEFHPTKNNILLSGDKKGQIGVWDFGKVYEKNVYGNIHSVQVNNMRFSPTNDDMVYSASSDGTIGYTDLETGTSSTLLNLNPDGWQGANSWKMLYGMDINSEKGVVLAADNFGFLHMIDHRTNNSTGEPILIHKQGSKVCGLDCNPVQPELLLSCGNDHFARIWDMRKLQPKASLHDLAHKRVVNSAYFSPSSGTKILTTCQDNRIRIWDSIFGNLDLPSREIVHSNDFNRHLTPFKAEWDPKDTSESLIVIGRYISENYNGTALHPIDFIDASNGQLVAEVMDPNITTITPVNKLHPRDDVLASGSSRSLFIWRPQDNTEMVEEKKDKKIIICYGDSKKKGKKQKRGSDDEDDEDDIFSSKGKNIKVNKYQAKTTKKTKT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
271	Phosphorylation	ANSWKMLYGMDINSE CCCCEEEEEEECCCC	13.60	19880383
525	Phosphorylation	GKKQKRGSDDEDDED CCCCCCCCCCCCCHH	46.02	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DDB2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DDB2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DDB2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DDB2_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DDB2_ARATH

Related Literatures of Post-Translational Modification