CLF_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLF_ARATH
• UniProt AC: P93831
• Protein Name: Histone-lysine N-methyltransferase CLF
• Gene Name: CLF
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 902
• Subcellular Localization: Nucleus .
• Protein Description: Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. Required to regulate floral development by repressing the AGAMOUS homeotic gene in leaves, influorescence stems and flowers. Regulates the antero-posterior organization of the endosperm, as well as the division and elongation rates of leaf cells. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development..
• Protein Sequence: MASEASPSSSATRSEPPKDSPAEERGPASKEVSEVIESLKKKLAADRCISIKKRIDENKKNLFAITQSFMRSSMERGGSCKDGSDLLVKRQRDSPGMKSGIDESNNNRYVEDGPASSGMVQGSSVPVKISLRPIKMPDIKRLSPYTTWVFLDRNQRMTEDQSVVGRRRIYYDQTGGEALICSDSEEEAIDDEEEKRDFLEPEDYIIRMTLEQLGLSDSVLAELASFLSRSTSEIKARHGVLMKEKEVSESGDNQAESSLLNKDMEGALDSFDNLFCRRCLVFDCRLHGCSQDLIFPAEKPAPWCPPVDENLTCGANCYKTLLKSGRFPGYGTIEGKTGTSSDGAGTKTTPTKFSSKLNGRKPKTFPSESASSNEKCALETSDSENGLQQDTNSDKVSSSPKVKGSGRRVGRKRNKNRVAERVPRKTQKRQKKTEASDSDSIASGSCSPSDAKHKDNEDATSSSQKHVKSGNSGKSRKNGTPAEVSNNSVKDDVPVCQSNEVASELDAPGSDESLRKEEFMGETVSRGRLATNKLWRPLEKSLFDKGVEIFGMNSCLIARNLLSGFKSCWEVFQYMTCSENKASFFGGDGLNPDGSSKFDINGNMVNNQVRRRSRFLRRRGKVRRLKYTWKSAAYHSIRKRITEKKDQPCRQFNPCNCKIACGKECPCLLNGTCCEKYCGCPKSCKNRFRGCHCAKSQCRSRQCPCFAADRECDPDVCRNCWVIGGDGSLGVPSQRGDNYECRNMKLLLKQQQRVLLGISDVSGWGAFLKNSVSKHEYLGEYTGELISHKEADKRGKIYDRENCSFLFNLNDQFVLDAYRKGDKLKFANHSPEPNCYAKVIMVAGDHRVGIFAKERILAGEELFYDYRYEPDRAPAWAKKPEAPGSKKDENVTPSVGRPKKLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
433	Phosphorylation	TQKRQKKTEASDSDS HHHHHHCCCCCCCCC	43.76	23660473
436	Phosphorylation	RQKKTEASDSDSIAS HHHCCCCCCCCCCCC	31.26	23660473
438	Phosphorylation	KKTEASDSDSIASGS HCCCCCCCCCCCCCC	30.66	23660473
440	Phosphorylation	TEASDSDSIASGSCS CCCCCCCCCCCCCCC	24.81	23660473
443	Phosphorylation	SDSDSIASGSCSPSD CCCCCCCCCCCCHHH	29.57	23660473
445	Phosphorylation	SDSIASGSCSPSDAK CCCCCCCCCCHHHHC	14.66	23660473
447	Phosphorylation	SIASGSCSPSDAKHK CCCCCCCCHHHHCCC	29.18	23660473
449	Phosphorylation	ASGSCSPSDAKHKDN CCCCCCHHHHCCCCC	33.63	23660473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLF_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLF_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLF_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EMF2_ARATH	EMF2	physical	15456723
FIE_ARATH	FIE	physical	14871310
VRN2_ARATH	VRN2	physical	16983073
VIL3_ARATH	VEL2	physical	20837520
MSI1_ARATH	MSI1	physical	23778966

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.