VRN2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VRN2_ARATH
• UniProt AC: Q8W5B1
• Protein Name: Polycomb group protein VERNALIZATION 2
• Gene Name: VRN2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 440
• Subcellular Localization: Nucleus.
• Protein Description: Polycomb group (PcG) protein. Plays a central role in vernalization by maintaining repressed the homeotic gene FLC, a floral repressor, after a cold treatment. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Associates constitutively along the whole FLC locus..
• Protein Sequence: MCRQNCRAKSSPEEVISTDENLLIYCKPVRLYNIFHLRSLGNPSFLPRCLNYKIGAKRKRKSRSTGMVVFNYKDCNNTLQRTEVREDCSCPFCSMLCGSFKGLQFHLNSSHDLFEFEFKLLEEYQTVNVSVKLNSFIFEEEGSDDDKFEPFSLCSKPRKRRQRGGRNNTRRLKVCFLPLDSPSLANGTENGIALLNDGNRGLGYPEATELAGQFEMTSNIPPAIAHSSLDAGAKVILTTEAVVPATKTRKLSAERSEARSHLLLQKRQFYHSHRVQPMALEQVMSDRDSEDEVDDDVADFEDRQMLDDFVDVNKDEKQFMHLWNSFVRKQRVIADGHISWACEVFSRFYEKELHCYSSLFWCWRLFLIKLWNHGLVDSATINNCNTILENCRNTSVTNNNNNSVDHPSDSNTNNNNIVDHPNDIKNKNNVDNKDNNSRDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
143	Phosphorylation	FIFEEEGSDDDKFEP EEEECCCCCCCCCCC	40.94	30407730
285	Phosphorylation	MALEQVMSDRDSEDE CHHHHHHCCCCCCCC	30.55	27531888
289	Phosphorylation	QVMSDRDSEDEVDDD HHHCCCCCCCCCCCC	48.09	27531888

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VRN2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VRN2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VRN2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FIE_ARATH	FIE	physical	16983073
CLF_ARATH	CLF	physical	16983073
EZA1_ARATH	SWN	physical	16983073
VIN3_ARATH	VIN3	physical	16983073
LHP1_ARATH	TFL2	physical	26025051

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.