LHP1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LHP1_ARATH
• UniProt AC: Q946J8
• Protein Name: Chromo domain-containing protein LHP1
• Gene Name: LHP1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 445
• Subcellular Localization: Nucleus . Punctuated distribution and in heterochromatic chromocenters.
• Protein Description: Structural component of heterochromatin involved in gene repression, including several floral homeotic genes and FLT that regulates flowering time. Required for maintenance of vernalization-induced repression of FLC. As part of the PRC1-like complex, recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me), leading to epigenetic repression. PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Transcriptional repressor that binds DNA on GAGA-like motif and 5'-(A/G/T)AACCCTA(A/G)-3' consensus motif in the promoters of target genes. Recognizes and binds histone H3 tails methylated at 'Lys-27' (H3K27me) but depleted in active histone marks such as H3K4me, leading to epigenetic repression. When in complex with LHP1, recognizes and binds histone H3 tails methylated at 'Lys-4' (H3K4me) and 'Lys-27' (H3K27me), mostly corresponding to stress-responsive genes. [PubMed: 27495811]
• Protein Sequence: MKGASGAVKKKPQVLNEAGEAETAVETVGESRKISGDGGFGSDDGGGGGGGGSGESILREIGDDRPTEDGDEEEEEDEDEDDGGDEEDEEGEGEGGQEERPKLDEGFYEIEAIRRKRVRKGKVQYLIKWRGWPETANTWEPLENLQSIADVIDAFEGSLKPGKPGRKRKRKYAGPHSQMKKKQRLTSTSHDATEKSDSSTSLNNSSLPDIPDPLDLSGSSLLNRDVEAKNAYVSNQVEANSGSVGMARQVRLIDNEKEYDPTLNELRGPVNNSNGAGCSQGGGIGSEGDNVRPNGLLKVYPKELDKNSRFIGAKRRKSGSVKRFKQDGSTSNNHTAPTDQNLTPDLTTLDSFGRIARMGNEYPGVMENCNLSQKTKIEELDITKILKPMSFTASVSDNVQEVLVTFLALRSDGKEALVDNRFLKAHNPHLLIEFYEQHLKYNRTP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	VGESRKISGDGGFGS HCCCCCCCCCCCCCC	33.59	30291188
42	Phosphorylation	SGDGGFGSDDGGGGG CCCCCCCCCCCCCCC	30.21	30291188
53	Phosphorylation	GGGGGGGSGESILRE CCCCCCCCHHHHHHH	42.54	23660473
189	Phosphorylation	KQRLTSTSHDATEKS HHCCCCCCCCCCCCC	21.09	25561503
196	Phosphorylation	SHDATEKSDSSTSLN CCCCCCCCCCCCCCC	36.17	30407730
198	Phosphorylation	DATEKSDSSTSLNNS CCCCCCCCCCCCCCC	42.48	30407730
199	Phosphorylation	ATEKSDSSTSLNNSS CCCCCCCCCCCCCCC	27.31	30407730
200	Phosphorylation	TEKSDSSTSLNNSSL CCCCCCCCCCCCCCC	40.98	30407730
201	Phosphorylation	EKSDSSTSLNNSSLP CCCCCCCCCCCCCCC	30.92	30407730
205	Phosphorylation	SSTSLNNSSLPDIPD CCCCCCCCCCCCCCC	31.98	30407730
206	Phosphorylation	STSLNNSSLPDIPDP CCCCCCCCCCCCCCC	46.15	30407730
241	Phosphorylation	SNQVEANSGSVGMAR CCCEECCCCCHHCEE	39.22	25561503
243	Phosphorylation	QVEANSGSVGMARQV CEECCCCCHHCEEEE	18.47	25561503
351	Phosphorylation	PDLTTLDSFGRIARM CCCCHHHHHHHHHHC	32.48	27531888
372	Phosphorylation	VMENCNLSQKTKIEE HHHCCCCCCCCCCEE	18.68	23572148
375	Phosphorylation	NCNLSQKTKIEELDI CCCCCCCCCCEECCH	29.62	23572148

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LHP1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LHP1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LHP1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATL55_ARATH	RING1	physical	19097900
LHP1_ARATH	TFL2	physical	11731464
LHP1_ARATH	TFL2	physical	21304947
MSI1_ARATH	MSI1	physical	23778966
EMF2_ARATH	EMF2	physical	23778966
H32_ARATH	AT5G65360	physical	19399177
SVP_ARATH	SVP	physical	19460347
CPY71_ARATH	CYP71	physical	21596687
CPY71_ARATH	CYP71	genetic	21596687

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.