CO8A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CO8A1_HUMAN
• UniProt AC: P27658
• Protein Name: Collagen alpha-1(VIII) chain
• Gene Name: COL8A1
• Organism: Homo sapiens (Human).
• Sequence Length: 744
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane.
• Protein Description: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.; Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis..
• Protein Sequence: MAVLPGPLQLLGVLLTISLSSIRLIQAGAYYGIKPLPPQIPPQMPPQIPQYQPLGQQVPHMPLAKDGLAMGKEMPHLQYGKEYPHLPQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGPPGPPGLPGHGIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPHAYGAKKGKNGGPAYEMPAFTAELTAPFPPVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNNEPVMYTYDEYKKGFLDQASGSAVLLLRPGDRVFLQMPSEQAAGLYAGQYVHSSFSGYLLYPM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	LGVLLTISLSSIRLI HHHHHHHCHHHHHHH	19.57	26546556
20	Phosphorylation	VLLTISLSSIRLIQA HHHHHCHHHHHHHHC	19.54	30301811
21	Phosphorylation	LLTISLSSIRLIQAG HHHHCHHHHHHHHCC	19.61	25954137
115	Phosphorylation	GKEIPLASLRGEQGP CCCCCHHHHCCCCCC	26.70	24719451
178	Acetylation	AMGMPGAKGEIGQKG CCCCCCCCCCCCCCC	64.09	7461981
577	O-linked_Glycosylation	PPAVMPPTPPPQGEY CCCCCCCCCCCCCCC	42.42	OGP
613	Phosphorylation	GKNGGPAYEMPAFTA CCCCCCCCCCCCEEE	18.85	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CO8A1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CO8A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CO8A1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KLH12_HUMAN	KLHL12	physical	16189514
KR412_HUMAN	KRTAP4-12	physical	16189514
FBLN4_HUMAN	EFEMP2	physical	16189514
CO8A2_HUMAN	COL8A2	physical	9705353
ATL4_HUMAN	ADAMTSL4	physical	19060904
REL_HUMAN	REL	physical	25416956
SP4_HUMAN	SP4	physical	25416956
CREB5_HUMAN	CREB5	physical	25416956
VAC14_HUMAN	VAC14	physical	25416956
KRA92_HUMAN	KRTAP9-2	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
INCA1_HUMAN	INCA1	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
KR261_HUMAN	KRTAP26-1	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.