CNGA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNGA3_HUMAN
• UniProt AC: Q16281
• Protein Name: Cyclic nucleotide-gated cation channel alpha-3
• Gene Name: CNGA3
• Organism: Homo sapiens (Human).
• Sequence Length: 694
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones..
• Protein Sequence: MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADSGQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQANVGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAKINTQYSHPSR --CCCCCCCCCCCCC	32.15	29083192
8	Phosphorylation	MAKINTQYSHPSRTH CCCCCCCCCCCCCCE	13.60	24076635
9	Phosphorylation	AKINTQYSHPSRTHL CCCCCCCCCCCCCEE	21.07	29083192
14	Phosphorylation	QYSHPSRTHLKVKTS CCCCCCCCEEEEECC	35.58	24076635
138	Acetylation	RSAWPLAKCNTNTSN CCCCCHHHCCCCCCC	35.38	20167786
154	Acetylation	TEEEKKTKKKDAIVV CHHHHHCCCCCCEEE	67.70	20167786
155	Acetylation	EEEKKTKKKDAIVVD HHHHHCCCCCCEEEC	62.20	20167786
168	Phosphorylation	VDPSSNLYYRWLTAI ECCCCCHHHHHHHHH	8.67	24248375
169	Phosphorylation	DPSSNLYYRWLTAIA CCCCCHHHHHHHHHH	9.85	24248375
282	Phosphorylation	FNRLLKFSRLFEFFD HHHHHHHHHHHHHHH	26.87	27251275
459	Phosphorylation	DEKEVLKSLPDKLKA CHHHHHHHCCHHHHH	40.76	25003641
476	Phosphorylation	AINVHLDTLKKVRIF EEEEEHHHCCEEEEE	47.00	-
580	Phosphorylation	YSDLFCLSKDDLMEA CHHEEEECHHHHHHH	34.91	-
689	Phosphorylation	VPGDATKTEDKQQ-- CCCCCCCCCCCCC--	45.09	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNGA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNGA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNGA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACBD5_HUMAN	ACBD5	physical	28514442
VPS52_HUMAN	VPS52	physical	28514442
SEMG2_HUMAN	SEMG2	physical	28514442
CA043_HUMAN	C1orf43	physical	28514442
ABCB9_HUMAN	ABCB9	physical	28514442
SEMG1_HUMAN	SEMG1	physical	28514442
PDZD8_HUMAN	PDZD8	physical	28514442
AT2A3_HUMAN	ATP2A3	physical	28514442
ADCY3_HUMAN	ADCY3	physical	28514442
RAB6B_HUMAN	RAB6B	physical	28514442
SNX14_HUMAN	SNX14	physical	28514442
TMX2_HUMAN	TMX2	physical	28514442
AVR2B_HUMAN	ACVR2B	physical	28514442
ANKL2_HUMAN	ANKLE2	physical	28514442
PKD2_HUMAN	PKD2	physical	28514442
C2C2L_HUMAN	C2CD2L	physical	28514442
ZMYM3_HUMAN	ZMYM3	physical	28514442
LNP_HUMAN	KIAA1715	physical	28514442
COMD3_HUMAN	COMMD3	physical	28514442
STX5_HUMAN	STX5	physical	28514442
ATLA3_HUMAN	ATL3	physical	28514442
MUL1_HUMAN	MUL1	physical	28514442
ATLA2_HUMAN	ATL2	physical	28514442
GHDC_HUMAN	GHDC	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00971: Achromatopsia; Rod monochromacy
• OMIM Disease
• 216900: Achromatopsia 2 (ACHM2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.