dbPTM

B2L14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	B2L14_HUMAN
UniProt AC	Q9BZR8
Protein Name	Apoptosis facilitator Bcl-2-like protein 14
Gene Name	BCL2L14
Organism	Homo sapiens (Human).
Sequence Length	327
Subcellular Localization	Cytoplasm . Isoform 1: Cytoplasm, cytosol. Diffusely distributed throughout the cytosol. Isoform 2: Endomembrane system. Predominantly localized to cytosolic organelles.
Protein Description	Plays a role in apoptosis..
Protein Sequence	MCSTSGCDLEEIPLDDDDLNTIEFKILAYYTRHHVFKSTPALFSPKLLRTRSLSQRGLGNCSANESWTEVSWPCRNSQSSEKAINLGKKKSSWKAFFGVVEKEDSQSTPAKVSAQGQRTLEYQDSHSQQWSRCLSNVEQCLEHEAVDPKVISIANRVAEIVYSWPPPQATQAGGFKSKEIFVTEGLSFQLQGHVPVASSSKKDEEEQILAKIVELLKYSGDQLERKLKKDKALMGHFQDGLSYSVFKTITDQVLMGVDPRGESEVKAQGFKAALVIDVTAKLTAIDNHPMNRVLGFGTKYLKENFSPWIQQHGGWEKILGISHEEVD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	TRHHVFKSTPALFSP HHHHHHCCCCCHHCH	28.32	-
44	Phosphorylation	KSTPALFSPKLLRTR CCCCCHHCHHHHHCC	23.21	24670416
50	Phosphorylation	FSPKLLRTRSLSQRG HCHHHHHCCCCHHCC	25.28	23312004
52	Phosphorylation	PKLLRTRSLSQRGLG HHHHHCCCCHHCCCC	31.59	23312004
54	Phosphorylation	LLRTRSLSQRGLGNC HHHCCCCHHCCCCCC	21.05	23312004
62	Phosphorylation	QRGLGNCSANESWTE HCCCCCCCCCCCCCE	37.82	25693802
66	Phosphorylation	GNCSANESWTEVSWP CCCCCCCCCCEECCC	38.82	27251275
68	Phosphorylation	CSANESWTEVSWPCR CCCCCCCCEECCCCC	35.47	27251275
71	Phosphorylation	NESWTEVSWPCRNSQ CCCCCEECCCCCCCC	21.04	28348404
113	Phosphorylation	QSTPAKVSAQGQRTL CCCCCEEEECCCEEE	17.73	27135362
125	Phosphorylation	RTLEYQDSHSQQWSR EEEEECCCCHHHHHH	14.98	27251275
135	Phosphorylation	QQWSRCLSNVEQCLE HHHHHHHHCHHHHHH	42.32	26657352
152	Phosphorylation	AVDPKVISIANRVAE CCCHHHHHHHHHHHH	20.73	23927012
183	Phosphorylation	KSKEIFVTEGLSFQL CCCEEEEECCCEEEE	17.37	29083192
187	Phosphorylation	IFVTEGLSFQLQGHV EEEECCCEEEEEEEC	23.08	29083192
198	Phosphorylation	QGHVPVASSSKKDEE EEECCCCCCCCCCHH	35.06	29083192
199	Phosphorylation	GHVPVASSSKKDEEE EECCCCCCCCCCHHH	36.12	29083192
200	Phosphorylation	HVPVASSSKKDEEEQ ECCCCCCCCCCHHHH	41.03	29083192
218	Phosphorylation	KIVELLKYSGDQLER HHHHHHHHCHHHHHH	20.18	26074081
219	Phosphorylation	IVELLKYSGDQLERK HHHHHHHCHHHHHHH	34.01	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of B2L14_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of B2L14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of B2L14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
B2CL1_HUMAN	BCL2L1	physical	11054413
CSN5_HUMAN	COPS5	physical	18006276
TPC10_HUMAN	TRAPPC10	physical	26186194
TPPC4_HUMAN	TRAPPC4	physical	26186194
MTA2_HUMAN	MTA2	physical	26186194
CG043_HUMAN	C7orf43	physical	26186194
2ABD_HUMAN	PPP2R2D	physical	26186194
TPPC9_HUMAN	TRAPPC9	physical	26186194
TPC6B_HUMAN	TRAPPC6B	physical	26186194
TPPC1_HUMAN	TRAPPC1	physical	26186194
TPPC3_HUMAN	TRAPPC3	physical	26186194
TPPC5_HUMAN	TRAPPC5	physical	26186194
TPC2L_HUMAN	TRAPPC2L	physical	26186194
TPC2A_HUMAN	TRAPPC2	physical	26186194
TPC2B_HUMAN	TRAPPC2	physical	26186194
CHK1_HUMAN	CHEK1	physical	26186194
VHL_HUMAN	VHL	physical	26186194
CG043_HUMAN	C7orf43	physical	28514442
TPPC9_HUMAN	TRAPPC9	physical	28514442
TPC6B_HUMAN	TRAPPC6B	physical	28514442
TPC10_HUMAN	TRAPPC10	physical	28514442
TPPC4_HUMAN	TRAPPC4	physical	28514442
TPC2L_HUMAN	TRAPPC2L	physical	28514442
TPPC1_HUMAN	TRAPPC1	physical	28514442
TPPC5_HUMAN	TRAPPC5	physical	28514442
TPPC3_HUMAN	TRAPPC3	physical	28514442
TPC2A_HUMAN	TRAPPC2	physical	28514442
TPC2B_HUMAN	TRAPPC2	physical	28514442
VHL_HUMAN	VHL	physical	28514442
MTA2_HUMAN	MTA2	physical	28514442
CHK1_HUMAN	CHEK1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of B2L14_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152, AND MASSSPECTROMETRY.	18088087 [Abstract]