| UniProt ID | 2ABG_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y2T4 | |
| Protein Name | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform | |
| Gene Name | PPP2R2C | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 447 | |
| Subcellular Localization | ||
| Protein Description | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.. | |
| Protein Sequence | MGEDTDTRKINHSFLRDHSYVTEADIISTVEFNHTGELLATGDKGGRVVIFQREPESKNAPHSQGEYDVYSTFQSHEPEFDYLKSLEIEEKINKIKWLPQQNAAHSLLSTNDKTIKLWKITERDKRPEGYNLKDEEGKLKDLSTVTSLQVPVLKPMDLMVEVSPRRIFANGHTYHINSISVNSDCETYMSADDLRINLWHLAITDRSFNIVDIKPANMEDLTEVITASEFHPHHCNLFVYSSSKGSLRLCDMRAAALCDKHSKLFEEPEDPSNRSFFSEIISSVSDVKFSHSGRYMLTRDYLTVKVWDLNMEARPIETYQVHDYLRSKLCSLYENDCIFDKFECAWNGSDSVIMTGAYNNFFRMFDRNTKRDVTLEASRESSKPRAVLKPRRVCVGGKRRRDDISVDSLDFTKKILHTAWHPAENIIAIAATNNLYIFQDKVNSDMH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 46 | Ubiquitination | LATGDKGGRVVIFQR EEECCCCCEEEEEEC | 25.58 | 24816145 | |
| 67 | Ubiquitination | APHSQGEYDVYSTFQ CCCCCCCCCHHHCCC | 19.96 | 23503661 | |
| 70 | Ubiquitination | SQGEYDVYSTFQSHE CCCCCCHHHCCCCCC | 10.09 | 23503661 | |
| 74 | Ubiquitination | YDVYSTFQSHEPEFD CCHHHCCCCCCCCCC | 43.92 | 29901268 | |
| 77 | Ubiquitination | YSTFQSHEPEFDYLK HHCCCCCCCCCCHHH | 52.34 | 29901268 | |
| 84 | Ubiquitination | EPEFDYLKSLEIEEK CCCCCHHHHHCHHHH | 46.92 | 29901268 | |
| 91 | Ubiquitination | KSLEIEEKINKIKWL HHHCHHHHHHHCCCC | 38.50 | 29901268 | |
| 108 (in isoform 3) | Ubiquitination | - | 7.13 | 21906983 | |
| 108 | Ubiquitination | QNAAHSLLSTNDKTI CCHHHHHHCCCCCEE | 7.13 | 24816145 | |
| 125 | Ubiquitination | WKITERDKRPEGYNL EEEECCCCCCCCCCC | 75.87 | 21906983 | |
| 125 (in isoform 2) | Ubiquitination | - | 75.87 | 21906983 | |
| 125 (in isoform 1) | Ubiquitination | - | 75.87 | 21906983 | |
| 246 (in isoform 3) | Ubiquitination | - | 17.66 | 21906983 | |
| 246 | Ubiquitination | VYSSSKGSLRLCDMR EEECCCCCEEECHHH | 17.66 | 24816145 | |
| 249 | Ubiquitination | SSKGSLRLCDMRAAA CCCCCEEECHHHHHH | 3.35 | 24816145 | |
| 256 | Ubiquitination | LCDMRAAALCDKHSK ECHHHHHHHHHHHHH | 14.03 | 24816145 | |
| 263 | Ubiquitination | ALCDKHSKLFEEPED HHHHHHHHHCCCCCC | 57.84 | 24816145 | |
| 263 (in isoform 2) | Ubiquitination | - | 57.84 | 21906983 | |
| 263 (in isoform 1) | Ubiquitination | - | 57.84 | 21906983 | |
| 272 | Phosphorylation | FEEPEDPSNRSFFSE CCCCCCCCCCHHHHH | 58.14 | 25627689 | |
| 318 | Phosphorylation | MEARPIETYQVHDYL CCCCCCEEECHHHHH | 21.70 | - | |
| 328 | Ubiquitination | VHDYLRSKLCSLYEN HHHHHHHHHHHHHCC | 47.26 | - | |
| 331 | Phosphorylation | YLRSKLCSLYENDCI HHHHHHHHHHCCCCC | 44.41 | 27251275 | |
| 349 | Phosphorylation | FECAWNGSDSVIMTG CEECCCCCCCEEEEC | 24.41 | 22210691 | |
| 351 | Phosphorylation | CAWNGSDSVIMTGAY ECCCCCCCEEEECCC | 18.42 | 22210691 | |
| 374 | Phosphorylation | RNTKRDVTLEASRES CCCCCCEEHHHHHHC | 24.14 | 29083192 | |
| 378 | Phosphorylation | RDVTLEASRESSKPR CCEEHHHHHHCCCCC | 27.49 | 29083192 | |
| 381 | Phosphorylation | TLEASRESSKPRAVL EHHHHHHCCCCCEEE | 42.42 | 29083192 | |
| 382 | Phosphorylation | LEASRESSKPRAVLK HHHHHHCCCCCEEEC | 41.76 | 29083192 | |
| 389 | Acetylation | SKPRAVLKPRRVCVG CCCCEEECCCEEEEC | 29.85 | 26051181 | |
| 405 | Phosphorylation | KRRRDDISVDSLDFT CCCCCCCCCCHHHCH | 27.20 | 16674116 | |
| 408 | Phosphorylation | RDDISVDSLDFTKKI CCCCCCCHHHCHHHH | 27.90 | 16674116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of 2ABG_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of 2ABG_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of 2ABG_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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