V2R_HUMAN - dbPTM
V2R_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID V2R_HUMAN
UniProt AC P30518
Protein Name Vasopressin V2 receptor
Gene Name AVPR2
Organism Homo sapiens (Human).
Sequence Length 371
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption..
Protein Sequence MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22N-linked_GlycosylationSLPSLPSNSSQERPL
CCCCCCCCCCCCCCC		43.68UniProtKB CARBOHYD
117PhosphorylationALCRAVKYLQMVGMY
HHHHHHHHHHHHHHH		8.7922817900
124PhosphorylationYLQMVGMYASSYMIL
HHHHHHHHHCHHHHH		9.45-
126PhosphorylationQMVGMYASSYMILAM
HHHHHHHCHHHHHHH		12.4326503892
128PhosphorylationVGMYASSYMILAMTL
HHHHHCHHHHHHHHH		5.9126503892
255PhosphorylationRRGRRTGSPGEGAHV
CCCCCCCCCCCCHHH		29.1728857561
325PhosphorylationSCTNPWIYASFSSSV
CCCCHHHHHHCCCCC		7.7312436935
341S-palmitoylationSELRSLLCCARGRTP
HHHHHHHHHHCCCCC		1.7512900404
342S-palmitoylationELRSLLCCARGRTPP
HHHHHHHHHCCCCCC		2.6712900404
362PhosphorylationDESCTTASSSLAKDT
CCCCCCCCHHHHCCC		20.549482866
363PhosphorylationESCTTASSSLAKDTS
CCCCCCCHHHHCCCC		27.239482866
364PhosphorylationSCTTASSSLAKDTSS
CCCCCCHHHHCCCCC		29.839482866
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
255SPhosphorylationKinasePRKACAP17612
GPS
255SPhosphorylationKinasePKA-FAMILY-GPS
362SPhosphorylationKinaseGRK-SUBFAMILY-GPS
363SPhosphorylationKinaseGRK-SUBFAMILY-GPS
364SPhosphorylationKinaseGRK-SUBFAMILY-GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of V2R_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of V2R_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MK03_HUMANMAPK3physical
12473660
ARRB2_HUMANARRB2physical
12473660
C1QT1_HUMANC1QTNF1physical
12409230
TERA_HUMANVCPphysical
18048502
DERL1_HUMANDERL1physical
18048502
CHIP_HUMANSTUB1physical
20974815
GBB1_HUMANGNB1physical
15782186
GBG2_HUMANGNG2physical
15782186
GNAS3_HUMANGNASphysical
15782186
GNAS2_HUMANGNASphysical
15782186
ALEX_HUMANGNASphysical
15782186
GNAS1_HUMANGNASphysical
15782186
ARRD4_HUMANARRDC4physical
23236378
HGS_HUMANHGSphysical
23236378
CLH1_HUMANCLTCphysical
23236378
V2R_HUMANAVPR2physical
10644689
NEU2_HUMANAVPphysical
10644689
Drug and Disease Associations
Kegg Disease
H00252 Congenital nephrogenic diabetes insipidus (NDI)
H01294 Nephrogenic syndrome of inappropriate antidiuresis (NSIAD)
OMIM Disease
300539Nephrogenic syndrome of inappropriate antidiuresis (NSIAD)
304800Diabetes insipidus, nephrogenic, X-linked (XNDI)
Kegg Drug
D00101 Vasopressin (JP16/USP); Pitressin (TN)
D00291 Desmopressin (INN)
D00366 Lypressin (USP/INN); Diapid (TN)
D01213 Tolvaptan (JAN/USAN/INN); Samsca (TN)
D01236 Conivaptan hydrochloride (JAN/USAN); Vaprisol (TN)
D01855 Mozavaptane hydrochloride (JAN)
D02235 Desmopressin acetate hydrate (JAN); Desmopressin acetate (USAN); Desmopressin acetate trihydrate; DD
D02983 Argipressin tannate (USAN); Pitressin tannate (TN)
D04752 Lixivaptan (USAN/INN)
D06672 Terlipressin (USAN/INN); Lucassin (TN)
D07227 Ornipressin (INN); POR 8 Sandoz (TN)
D07748 Conivaptan (INN)
D08571 Terlipressin acetate (JAN); Heamopressin (TN)
D09820 Vasopressin tannate (JAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of V2R_HUMAN

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Related Literatures of Post-Translational Modification
Palmitoylation
ReferencePubMed
"Palmitoylation of the V2 vasopressin receptor.";
Sadeghi H.M., Innamorati G., Dagarag M., Birnbaumer M.;
Mol. Pharmacol. 52:21-29(1997).
Cited for: PALMITOYLATION AT CYS-341 AND CYS-342, AND MUTAGENESIS OF CYS-341 ANDCYS-342.

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