ARRD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARRD4_HUMAN
• UniProt AC: Q8NCT1
• Protein Name: Arrestin domain-containing protein 4
• Gene Name: ARRDC4
• Organism: Homo sapiens (Human).
• Sequence Length: 418
• Subcellular Localization: Early endosome . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle . Also found in extracellular vesicles different from exosomes.
• Protein Description: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake. [PubMed: 19605364]
• Protein Sequence: MGGEAGCAAAVGAEGRVKSLGLVFEDERKGCYSSGETVAGHVLLEASEPVALRALRLEAQGRATAAWGPSTCPRASASTAALAVFSEVEYLNVRLSLREPPAGEGIILLQPGKHEFPFRFQLPSEPLVTSFTGKYGSIQYCVRAVLERPKVPDQSVKRELQVVSHVDVNTPALLTPVLKTQEKMVGCWFFTSGPVSLSAKIERKGYCNGEAIPIYAEIENCSSRLIVPKAAIFQTQTYLASGKTKTIRHMVANVRGNHIASGSTDTWNGKTLKIPPVTPSILDCCIIRVDYSLAVYIHIPGAKKLMLELPLVIGTIPYNGFGSRNSSIASQFSMDMSWLTLTLPEQPEAPPNYADVVSEEEFSRHIPPYPQPPNCEGEVCCPVFACIQEFRFQPPPLYSEVDPHPSDVEESQPVSFIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	GCYSSGETVAGHVLL CCCCCCCEECCEEEE	21.12	22817900
76	Phosphorylation	PSTCPRASASTAALA CCCCCCCCHHHHHHH	24.83	29116813
96	Phosphorylation	EYLNVRLSLREPPAG EEEEEEEEECCCCCC	18.15	23532336
206	Phosphorylation	AKIERKGYCNGEAIP EEEEECCCCCCCEEC	5.93	-
229	Ubiquitination	SSRLIVPKAAIFQTQ CCCCEECHHHHEECH	39.29	21890473
291	Phosphorylation	CCIIRVDYSLAVYIH HEEEEECEEEEEEEE	11.61	-
292	Phosphorylation	CIIRVDYSLAVYIHI EEEEECEEEEEEEEC	12.85	-
296	Phosphorylation	VDYSLAVYIHIPGAK ECEEEEEEEECCCHH	4.91	-
398	Phosphorylation	RFQPPPLYSEVDPHP CCCCCCCCCCCCCCC	14.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARRD4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARRD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARRD4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NED4L_HUMAN	NEDD4L	physical	23236378
ITCH_HUMAN	ITCH	physical	23236378
WWP2_HUMAN	WWP2	physical	23236378
ARRB1_HUMAN	ARRB1	physical	23236378
ARRB2_HUMAN	ARRB2	physical	23236378
ADRB2_HUMAN	ADRB2	physical	21982743
V2R_HUMAN	AVPR2	physical	23236378

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-37, AND MASSSPECTROMETRY.
PubMed: 18187866