THI11_YEAST - dbPTM
THI11_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID THI11_YEAST
UniProt AC P47183
Protein Name 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI11 {ECO:0000250|UniProtKB:P43534}
Gene Name THI11 {ECO:0000303|PubMed:12777485}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 340
Subcellular Localization
Protein Description Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme..
Protein Sequence MSTDKITFLLNWQPTPYHIPIFLAQTKGYFKEQGLDIAILEPTNPSDVTELIGSGKVDMGLKAMIHTLAAKARGFPVTSVASLLDEPFTGVLYLKGSGITEDFQSLKGKKIGYVGEFGKIQIDELTKHYGMKPEDYTAVRCGMNVAKYIIEDKIDAGIGIECMQQVELEEYLAKQGRPASDAKMLRIDKLACLGCCCFCTVLYICNDEFLKKNPEKVRKFLKAIKKATDYVLADPVKAWKEYIDFKPQLNNDLSYKQYQRCYAYFSSSLYNVHRDWKKVTGYGKRLAILPPDYVSNYTNEYLSWPEPEEVSDPLEAQRLMAIHQEKCRQEGTFKRLALPA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
62N6-(pyridoxal phosphate)lysineGKVDMGLKAMIHTLA
CCCCHHHHHHHHHHH		30.13-
62OtherGKVDMGLKAMIHTLA
CCCCHHHHHHHHHHH		30.13-
280PhosphorylationHRDWKKVTGYGKRLA
HCCHHHHCCCCCEEE		33.3030377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of THI11_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of THI11_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of THI11_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PIL1_YEASTPIL1physical
16554755
ATG17_YEASTATG17physical
16554755
ATC7_YEASTNEO1genetic
27708008
DBP6_YEASTDBP6genetic
27708008
KPC1_YEASTPKC1genetic
27708008
CDK1_YEASTCDC28genetic
27708008
CDC10_YEASTCDC10genetic
27708008
PRP9_YEASTPRP9genetic
27708008
UAP1_YEASTQRI1genetic
27708008
TIM22_YEASTTIM22genetic
27708008
CDC13_YEASTCDC13genetic
27708008
YRB1_YEASTYRB1genetic
27708008
PSF1_YEASTPSF1genetic
27708008
RPC10_YEASTRPC11genetic
27708008
CDC37_YEASTCDC37genetic
27708008
SLD5_YEASTSLD5genetic
27708008
CDC4_YEASTCDC4genetic
27708008
CDC14_YEASTCDC14genetic
27708008
CDC12_YEASTCDC12genetic
27708008
DNA2_YEASTDNA2genetic
27708008
STS1_YEASTSTS1genetic
27708008
PRP21_YEASTPRP21genetic
27708008
RFC2_YEASTRFC2genetic
27708008
CDC11_YEASTCDC11genetic
27708008
CDC3_YEASTCDC3genetic
27708008
POB3_YEASTPOB3genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
DPOA_YEASTPOL1genetic
27708008
TOA1_YEASTTOA1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of THI11_YEAST

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Related Literatures of Post-Translational Modification

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