ROR1_HUMAN - dbPTM
ROR1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ROR1_HUMAN
UniProt AC Q01973
Protein Name Inactive tyrosine-protein kinase transmembrane receptor ROR1 {ECO:0000305}
Gene Name ROR1
Organism Homo sapiens (Human).
Sequence Length 937
Subcellular Localization Membrane
Single-pass type I membrane protein. Cell projection, axon .
Protein Description Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. [PubMed: 25029443 Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling]
Protein Sequence MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIALLFFFICVCRNNQKSSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRYPNYMFPSQGITPQGQIAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTGPPRVIQHCPPPKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLLPHMSIPNHPGGMGITVFGNKSQKPYKIDSKQASLLGDANIHGHTESMISAEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationHRPRRRGTRPPLLAL
CCCCCCCCCHHHHHH		37.89-
47N-linked_GlycosylationLVPTSSWNISSELNK
ECCCCCCCCCCCCCC		26.64UniProtKB CARBOHYD
66N-linked_GlycosylationTLDEPMNNITTSLGQ
CCCCCCHHCCCCCCC		27.08UniProtKB CARBOHYD
106PhosphorylationVQEPRRLSFRSTIYG
CCCCCCCCCCCEEEC		19.4628152594
109PhosphorylationPRRLSFRSTIYGSRL
CCCCCCCCEEECCEE		19.6928152594
110PhosphorylationRRLSFRSTIYGSRLR
CCCCCCCEEECCEEE		17.6028152594
112PhosphorylationLSFRSTIYGSRLRIR
CCCCCEEECCEEEEC		14.7728152594
114PhosphorylationFRSTIYGSRLRIRNL
CCCEEECCEEEECCC		15.9228152594
160PhosphorylationPPTASPGYSDEYEED
CCCCCCCCCCCCCCC		19.1422817900
161PhosphorylationPTASPGYSDEYEEDG
CCCCCCCCCCCCCCC		29.85-
173PhosphorylationEDGFCQPYRGIACAR
CCCCCCCCCCCEEEE		8.8022817900
184N-linked_GlycosylationACARFIGNRTVYMES
EEEEEECCEEEEEEE		31.47UniProtKB CARBOHYD
269PhosphorylationTEYIFARSNPMILMR
CEEEEECCCCEEEEE		41.6827251275
315N-linked_GlycosylationNKNHKCYNSTGVDYR
CCCCCCCCCCCCCCC		42.43UniProtKB CARBOHYD
328PhosphorylationYRGTVSVTKSGRQCQ
CCCEEEECCCCCCCC		16.4033259812
360PhosphorylationPELNGGHSYCRNPGN
CCCCCCCCCCCCCCC		29.2424114839
393 (in isoform 3)Acetylation-37.94-
401UbiquitinationKDSKEKNKMEILYIL
CCCCCCCCCCHHHHH		49.3225015289
423UbiquitinationLAIALLFFFICVCRN
HHHHHHHHHHHHHCC		3.9923000965
426UbiquitinationALLFFFICVCRNNQK
HHHHHHHHHHCCCCC		1.6823000965
434PhosphorylationVCRNNQKSSSAPVQR
HHCCCCCCCCCCCCC		21.5530576142
444UbiquitinationAPVQRQPKHVRGQNV
CCCCCCCCCCCCCCC		46.5225015289
464UbiquitinationNAYKPKSKAKELPLS
HHCCCHHHCCCCCHH		70.3825015289
466UbiquitinationYKPKSKAKELPLSAV
CCCHHHCCCCCHHHH		64.6223000965
469UbiquitinationKSKAKELPLSAVRFM
HHHCCCCCHHHHHHH		25.9223000965
486UbiquitinationLGECAFGKIYKGHLY
HCCCCCCEEECCEEE		36.0923000965
489UbiquitinationCAFGKIYKGHLYLPG
CCCCEEECCEEECCC		43.2423000965
506UbiquitinationHAQLVAIKTLKDYNN
HHHEEEEEEHHHCCC		37.7633845483
571PhosphorylationLIMRSPHSDVGCSSD
EEECCCCCCCCCCCC		37.0630576142
576PhosphorylationPHSDVGCSSDEDGTV
CCCCCCCCCCCCCCE		34.5930576142
577PhosphorylationHSDVGCSSDEDGTVK
CCCCCCCCCCCCCEE		49.4430576142
582PhosphorylationCSSDEDGTVKSSLDH
CCCCCCCCEEECCCC		36.7625841592
588UbiquitinationGTVKSSLDHGDFLHI
CCEEECCCCCCHHHH		45.7523000965
614UbiquitinationSSHFFVHKDLAARNI
HHCCCCCHHHHHHCC		49.49-
630UbiquitinationIGEQLHVKISDLGLS
ECCEEEEEHHHHCCC		26.2433845483
631UbiquitinationGEQLHVKISDLGLSR
CCEEEEEHHHHCCCC		3.6323000965
645PhosphorylationREIYSADYYRVQSKS
CEEEECEEEEECCCC		7.9023403867
646PhosphorylationEIYSADYYRVQSKSL
EEEECEEEEECCCCC		12.5923403867
650PhosphorylationADYYRVQSKSLLPIR
CEEEEECCCCCCCCE		22.7323403867
651UbiquitinationDYYRVQSKSLLPIRW
EEEEECCCCCCCCEE		28.2123000965
776PhosphorylationQTTSLSASPVSNLSN
CCCCCCCCCCCCCCC		23.5827422710
786PhosphorylationSNLSNPRYPNYMFPS
CCCCCCCCCCCCCCC		9.3327259358
789PhosphorylationSNPRYPNYMFPSQGI
CCCCCCCCCCCCCCC		8.8127259358
828PhosphorylationGYPIPPGYAAFPAAH
CEECCCCCCCCCCCC		10.6722322096
836PhosphorylationAAFPAAHYQPTGPPR
CCCCCCCCCCCCCCC		16.0922322096
853PhosphorylationQHCPPPKSRSPSSAS
CCCCCCCCCCCCCCC		43.7121406692
855PhosphorylationCPPPKSRSPSSASGS
CCCCCCCCCCCCCCC		35.9021406692
857PhosphorylationPPKSRSPSSASGSTS
CCCCCCCCCCCCCCC		39.5221406692
858PhosphorylationPKSRSPSSASGSTST
CCCCCCCCCCCCCCC		29.8221406692
860PhosphorylationSRSPSSASGSTSTGH
CCCCCCCCCCCCCCE		34.9121406692
862PhosphorylationSPSSASGSTSTGHVT
CCCCCCCCCCCCEEE		19.3821406692
863PhosphorylationPSSASGSTSTGHVTS
CCCCCCCCCCCEEEE		33.5621406692
864PhosphorylationSSASGSTSTGHVTSL
CCCCCCCCCCEEEEC		33.8021406692
865PhosphorylationSASGSTSTGHVTSLP
CCCCCCCCCEEEECC		31.2521406692
869PhosphorylationSTSTGHVTSLPSSGS
CCCCCEEEECCCCCC		20.9021406692
870PhosphorylationTSTGHVTSLPSSGSN
CCCCEEEECCCCCCC		36.8721406692
873PhosphorylationGHVTSLPSSGSNQEA
CEEEECCCCCCCCCC		53.2621406692
874PhosphorylationHVTSLPSSGSNQEAN
EEEECCCCCCCCCCC		44.2821406692
876PhosphorylationTSLPSSGSNQEANIP
EECCCCCCCCCCCCC		36.9721406692
889PhosphorylationIPLLPHMSIPNHPGG
CCCCCCCCCCCCCCC		31.6821406692
900PhosphorylationHPGGMGITVFGNKSQ
CCCCCEEEEECCCCC		12.2121406692
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ROR1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ROR1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ROR1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
RO52_HUMANTRIM21physical
23153538
MORC3_HUMANMORC3physical
23153538
TBCD1_HUMANTBC1D1physical
23153538
TBCD4_HUMANTBC1D4physical
23153538
TOP1_HUMANTOP1genetic
28319113
SNF5_HUMANSMARCB1genetic
28319113
VHL_HUMANVHLgenetic
28319113
PPM1B_HUMANPPM1Bphysical
28065597
PPM1F_HUMANPPM1Fphysical
28065597
ILKAP_HUMANILKAPphysical
28065597
PTPRR_HUMANPTPRRphysical
28065597
PTN6_HUMANPTPN6physical
28065597
DUS14_HUMANDUSP14physical
28065597
DUS18_HUMANDUSP18physical
28065597
DUS19_HUMANDUSP19physical
28065597
DUS21_HUMANDUSP21physical
28065597
DUPD1_HUMANDUPD1physical
28065597
STYX_HUMANSTYXphysical
28065597
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ROR1_HUMAN

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Related Literatures of Post-Translational Modification

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