MORC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MORC3_HUMAN
• UniProt AC: Q14149
• Protein Name: MORC family CW-type zinc finger protein 3
• Gene Name: MORC3 {ECO:0000312|HGNC:HGNC:23572}
• Organism: Homo sapiens (Human).
• Sequence Length: 939
• Subcellular Localization: Nucleus, nucleoplasm . Nucleus matrix . Nucleus, PML body . Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent.
• Protein Description: Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism. [PubMed: 20501696 Sumoylated MORC3-NBs can also associate with PML-NBs]
• Protein Sequence: MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	PPRGIRLSALCPKFL CCCCEEHHHCCCCCC	14.89	25159151
79	Ubiquitination	MTSDKLHKMLSFGFS CCHHHHHHHHHCCCC	52.55	-
82	Phosphorylation	DKLHKMLSFGFSDKV HHHHHHHHCCCCCCE	21.59	-
105	Ubiquitination	GLYGNGFKSGSMRLG EECCCCCCCCCCCCC	56.13	-
106	Phosphorylation	LYGNGFKSGSMRLGK ECCCCCCCCCCCCCC	33.56	24144214
108	Phosphorylation	GNGFKSGSMRLGKDA CCCCCCCCCCCCCCE	14.07	24144214
152	Ubiquitination	VPIVAFNKHRQMINL EEEEEEHHHHHHHHH	33.44	-
191	Sumoylation	ELDAIIGKKGTRIII HHHHHHCCCCCEEEE	37.31	28112733
191	Ubiquitination	ELDAIIGKKGTRIII HHHHHHCCCCCEEEE	37.31	-
192	Ubiquitination	LDAIIGKKGTRIIIW HHHHHCCCCCEEEEE	61.37	-
205	Sumoylation	IWNLRSYKNATEFDF EEECCCCCCCCCCCC	41.16	-
205	Sumoylation	IWNLRSYKNATEFDF EEECCCCCCCCCCCC	41.16	28112733
214	Ubiquitination	ATEFDFEKDKYDIRI CCCCCCCCCCCCCCC	60.56	-
216	Ubiquitination	EFDFEKDKYDIRIPE CCCCCCCCCCCCCCC	56.76	-
231	Acetylation	DLDEITGKKGYKKQE CHHHHCCCCCCCHHH	34.08	25953088
231	Sumoylation	DLDEITGKKGYKKQE CHHHHCCCCCCCHHH	34.08	28112733
231	Ubiquitination	DLDEITGKKGYKKQE CHHHHCCCCCCCHHH	34.08	21906983
232	Ubiquitination	LDEITGKKGYKKQER HHHHCCCCCCCHHHH	69.67	21890473
250	Phosphorylation	IAPESDYSLRAYCSI HCCCCHHHHHHHHHH	19.17	24719451
254	Phosphorylation	SDYSLRAYCSILYLK CHHHHHHHHHHEEEE	4.74	-
259	Phosphorylation	RAYCSILYLKPRMQI HHHHHHEEEECCEEE	15.83	-
261	Methylation	YCSILYLKPRMQIIL HHHHEEEECCEEEEC	19.61	-
261	Ubiquitination	YCSILYLKPRMQIIL HHHHEEEECCEEEEC	19.61	-
274	Ubiquitination	ILRGQKVKTQLVSKS ECCCCHHHHHHHCHH	37.27	-
280	Sumoylation	VKTQLVSKSLAYIER HHHHHHCHHHHHHHH	41.85	28112733
280	Ubiquitination	VKTQLVSKSLAYIER HHHHHHCHHHHHHHH	41.85	21890473
293	Sumoylation	ERDVYRPKFLSKTVR HHCCCCCCCCCCEEE	50.36	28112733
293	Ubiquitination	ERDVYRPKFLSKTVR HHCCCCCCCCCCEEE	50.36	21890473
296	Phosphorylation	VYRPKFLSKTVRITF CCCCCCCCCEEEEEE	29.43	26074081
297	Ubiquitination	YRPKFLSKTVRITFG CCCCCCCCEEEEEEE	53.86	-
298	Phosphorylation	RPKFLSKTVRITFGF CCCCCCCEEEEEEEE	16.19	26074081
302	Phosphorylation	LSKTVRITFGFNCRN CCCEEEEEEEECCCC	13.72	26074081
310	Ubiquitination	FGFNCRNKDHYGIMM EEECCCCCCCEEEEE	26.91	-
313	Phosphorylation	NCRNKDHYGIMMYHR CCCCCCCEEEEEEEH	20.62	26074081
318	Phosphorylation	DHYGIMMYHRNRLIK CCEEEEEEEHHHHHH	4.73	26074081
325	Ubiquitination	YHRNRLIKAYEKVGC EEHHHHHHHHHHHCC	49.89	-
329	Ubiquitination	RLIKAYEKVGCQLRA HHHHHHHHHCCCCCC	31.11	-
353	Ubiquitination	IIECNFLKPTHNKQD EEECCCCCCCCCCCC	43.67	-
358	Ubiquitination	FLKPTHNKQDFDYTN CCCCCCCCCCCCCCC	43.57	-
377	Ubiquitination	TITALGEKLNDYWNE EEEHHHHHHHHHHHH	51.28	21906983
378	Ubiquitination	ITALGEKLNDYWNEM EEHHHHHHHHHHHHC	5.26	21890473
386	Ubiquitination	NDYWNEMKVKKNTEY HHHHHHCCCCCCCCC	44.73	-
388	Ubiquitination	YWNEMKVKKNTEYPL HHHHCCCCCCCCCCC	34.48	-
389	Ubiquitination	WNEMKVKKNTEYPLN HHHCCCCCCCCCCCC	72.58	21906983
390	Ubiquitination	NEMKVKKNTEYPLNL HHCCCCCCCCCCCCC	32.21	21890473
391	Phosphorylation	EMKVKKNTEYPLNLP HCCCCCCCCCCCCCC	45.86	24260401
393	Phosphorylation	KVKKNTEYPLNLPVE CCCCCCCCCCCCCHH	15.81	24260401
404	Ubiquitination	LPVEDIQKRPDQTWV CCHHHHHHCCCCCEE	67.25	-
421	Ubiquitination	DACLKWRKLPDGMDQ CHHCCCCCCCCCHHC	64.36	-
432	Ubiquitination	GMDQLPEKWYCSNNP CHHCCCHHHCCCCCC	41.33	-
434	Phosphorylation	DQLPEKWYCSNNPDP HCCCHHHCCCCCCCC	9.32	17360941
461	Phosphorylation	DEDLVHPTYEKTYKK CCCCCCCCCHHHCHH	29.45	28796482
462	Phosphorylation	EDLVHPTYEKTYKKT CCCCCCCCHHHCHHC	21.63	28796482
464	Ubiquitination	LVHPTYEKTYKKTNK CCCCCCHHHCHHCCH	46.90	-
468	Ubiquitination	TYEKTYKKTNKEKFR CCHHHCHHCCHHHHC	47.09	-
494	Phosphorylation	AELLFRPTALSTPSF HHHEECCCCCCCCCC	35.65	24732914
497	Phosphorylation	LFRPTALSTPSFSSP EECCCCCCCCCCCCC	35.49	24732914
498	Phosphorylation	FRPTALSTPSFSSPK ECCCCCCCCCCCCCC	24.65	21712546
500	Phosphorylation	PTALSTPSFSSPKES CCCCCCCCCCCCCHH	37.54	21712546
502	Phosphorylation	ALSTPSFSSPKESVP CCCCCCCCCCCHHCC	50.50	25159151
503	Phosphorylation	LSTPSFSSPKESVPR CCCCCCCCCCHHCCC	37.67	21712546
507	Phosphorylation	SFSSPKESVPRRHLS CCCCCCHHCCCCCCC	43.48	24732914
514	Phosphorylation	SVPRRHLSEGTNSYA HCCCCCCCCCCCHHH	28.05	23401153
517	Phosphorylation	RRHLSEGTNSYATRL CCCCCCCCCHHHHHH	19.55	28857561
519	Phosphorylation	HLSEGTNSYATRLLN CCCCCCCHHHHHHHH	18.91	26434776
520	Phosphorylation	LSEGTNSYATRLLNN CCCCCCHHHHHHHHC	17.67	23186163
522	Phosphorylation	EGTNSYATRLLNNHQ CCCCHHHHHHHHCCC	17.39	26434776
538	Phosphorylation	PPQSEPESNSLKRRL CCCCCCCCHHHHHHH	42.29	28555341
540	Phosphorylation	QSEPESNSLKRRLST CCCCCCHHHHHHHHH	44.54	25159151
542	Ubiquitination	EPESNSLKRRLSTRS CCCCHHHHHHHHHHH	34.98	-
546	Phosphorylation	NSLKRRLSTRSSILN HHHHHHHHHHHHHHH	21.69	23401153
547	Phosphorylation	SLKRRLSTRSSILNA HHHHHHHHHHHHHHH	38.88	23401153
549	Phosphorylation	KRRLSTRSSILNAKN HHHHHHHHHHHHHHH	23.09	28450419
550	Phosphorylation	RRLSTRSSILNAKNR HHHHHHHHHHHHHHH	28.01	25159151
555	Sumoylation	RSSILNAKNRRLSSQ HHHHHHHHHHHHHHH	50.33	28112733
555	Ubiquitination	RSSILNAKNRRLSSQ HHHHHHHHHHHHHHH	50.33	-
560	Phosphorylation	NAKNRRLSSQFENSV HHHHHHHHHHHHCCC	21.93	23401153
561	O-linked_Glycosylation	AKNRRLSSQFENSVY HHHHHHHHHHHCCCC	43.40	30379171
561	Phosphorylation	AKNRRLSSQFENSVY HHHHHHHHHHHCCCC	43.40	25159151
566	Phosphorylation	LSSQFENSVYKGDDD HHHHHHCCCCCCCCC	21.45	29978859
568	Phosphorylation	SQFENSVYKGDDDDE HHHHCCCCCCCCCCC	14.74	23312004
584	Phosphorylation	VIILEENSTPKPAVD EEEEECCCCCCCCCC	49.74	25159151
585	Phosphorylation	IILEENSTPKPAVDH EEEECCCCCCCCCCC	47.08	25159151
597	Sumoylation	VDHDIDMKSEQSHVE CCCCCCCCCCCCHHH	47.28	-
597	Sumoylation	VDHDIDMKSEQSHVE CCCCCCCCCCCCHHH	47.28	20501696
650	Sumoylation	EVPSLVVKKEETVED CCCEEEECCCEECCC	47.16	-
650	Sumoylation	EVPSLVVKKEETVED CCCEEEECCCEECCC	47.16	20501696
651	Sumoylation	VPSLVVKKEETVEDE CCEEEECCCEECCCC	49.53	-
651	Sumoylation	VPSLVVKKEETVEDE CCEEEECCCEECCCC	49.53	20501696
681	Phosphorylation	AEAKIHETQETTDKS HHHHHHCCCHHCCCC	19.97	-
684	Phosphorylation	KIHETQETTDKSADD HHHCCCHHCCCCCHH	30.40	29759185
685	Phosphorylation	IHETQETTDKSADDA HHCCCHHCCCCCHHH	40.45	29759185
687	Ubiquitination	ETQETTDKSADDAGC CCCHHCCCCCHHHCH	45.51	21906983
688	Ubiquitination	TQETTDKSADDAGCQ CCHHCCCCCHHHCHH	39.48	21890473
710	Ubiquitination	LLLVTEEKENYKRQC HEEEHHCHHHHHHHH	45.06	21890473
737	Acetylation	RILEMNDKYVKKETC HHHHHCHHHCCHHHC	47.11	12437819
740	Sumoylation	EMNDKYVKKETCHQS HHCHHHCCHHHCCCC	41.63	-
740	Sumoylation	EMNDKYVKKETCHQS HHCHHHCCHHHCCCC	41.63	20501696
762	Ubiquitination	LLESINGKSESPDHM EHHHHCCCCCCCHHH	46.71	-
763	Phosphorylation	LESINGKSESPDHMV HHHHCCCCCCCHHHH	44.71	30266825
765	Phosphorylation	SINGKSESPDHMVSQ HHCCCCCCCHHHHHH	42.60	25159151
771	Phosphorylation	ESPDHMVSQYQQALE CCCHHHHHHHHHHHH	18.65	23927012
773	Phosphorylation	PDHMVSQYQQALEEI CHHHHHHHHHHHHHH	8.62	23927012
785	Ubiquitination	EEIERLKKQCSALQH HHHHHHHHHHHHHHH	62.22	-
794	Sumoylation	CSALQHVKAECSQCS HHHHHHHHHHHHHCC	36.02	-
794	Sumoylation	CSALQHVKAECSQCS HHHHHHHHHHHHHCC	36.02	20501696
794	Ubiquitination	CSALQHVKAECSQCS HHHHHHHHHHHHHCC	36.02	-
798	Phosphorylation	QHVKAECSQCSNNES HHHHHHHHHCCCCCC	26.23	-
801	Phosphorylation	KAECSQCSNNESKSE HHHHHHCCCCCCHHH	34.74	21712546
805	Phosphorylation	SQCSNNESKSEMDEM HHCCCCCCHHHHHHH	43.54	21712546
806	Ubiquitination	QCSNNESKSEMDEMA HCCCCCCHHHHHHHH	44.23	21906983
807	Phosphorylation	CSNNESKSEMDEMAV CCCCCCHHHHHHHHH	47.64	21712546
807	Ubiquitination	CSNNESKSEMDEMAV CCCCCCHHHHHHHHH	47.64	21890473
825	Ubiquitination	DVFRQLDKCSIERDQ HHHHHHHHCCCCHHH	38.17	21890473
826	Ubiquitination	VFRQLDKCSIERDQY HHHHHHHCCCCHHHH	5.03	21890473
834	Ubiquitination	SIERDQYKSEVELLE CCCHHHHHHHHHHHH	34.21	21906983
835	Ubiquitination	IERDQYKSEVELLEM CCHHHHHHHHHHHHH	41.77	21890473
844	Ubiquitination	VELLEMEKSQIRSQC HHHHHHHHHHHHHHH	46.48	21906983
845	Phosphorylation	ELLEMEKSQIRSQCE HHHHHHHHHHHHHHH	19.96	28122231
845	Ubiquitination	ELLEMEKSQIRSQCE HHHHHHHHHHHHHHH	19.96	21890473
855	Sumoylation	RSQCEELKTEVEQLK HHHHHHHHHHHHHHH	46.01	-
855	Sumoylation	RSQCEELKTEVEQLK HHHHHHHHHHHHHHH	46.01	28112733
855	Ubiquitination	RSQCEELKTEVEQLK HHHHHHHHHHHHHHH	46.01	-
862	Ubiquitination	KTEVEQLKSTNQQTA HHHHHHHHHCCCCCC	55.73	21906983
863	Phosphorylation	TEVEQLKSTNQQTAT HHHHHHHHCCCCCCC	40.98	30576142
863	Ubiquitination	TEVEQLKSTNQQTAT HHHHHHHHCCCCCCC	40.98	21890473
864	Phosphorylation	EVEQLKSTNQQTATD HHHHHHHCCCCCCCC	35.14	29449344
868	Phosphorylation	LKSTNQQTATDVSTS HHHCCCCCCCCCCCC	23.04	29449344
870	Phosphorylation	STNQQTATDVSTSSN HCCCCCCCCCCCCCC	40.08	29449344
873	Phosphorylation	QQTATDVSTSSNIEE CCCCCCCCCCCCHHH	25.94	30576142
874	Phosphorylation	QTATDVSTSSNIEES CCCCCCCCCCCHHHH	35.70	21712546
875	Phosphorylation	TATDVSTSSNIEESV CCCCCCCCCCHHHHH	17.55	21712546
876	Phosphorylation	ATDVSTSSNIEESVN CCCCCCCCCHHHHHH	41.75	21712546
881	Phosphorylation	TSSNIEESVNHMDGE CCCCHHHHHHCCCCC	18.54	29449344
891	Ubiquitination	HMDGESLKLRSLRVN CCCCCCCCHHEEEEE	51.65	21890473
892	Ubiquitination	MDGESLKLRSLRVNV CCCCCCCHHEEEEEH	5.65	21890473
894	Phosphorylation	GESLKLRSLRVNVGQ CCCCCHHEEEEEHHH	30.85	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	ICP0	P08393	PMID:32416261

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MORC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MORC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HD_HUMAN	HTT	physical	26496610
SNTB1_HUMAN	SNTB1	physical	26496610
MOGS_HUMAN	MOGS	physical	26496610
DYL1_HUMAN	DYNLL1	physical	26496610
CRIPT_HUMAN	CRIPT	physical	26496610
TRIB1_HUMAN	TRIB1	physical	26496610
SYNE2_HUMAN	SYNE2	physical	26496610
DEP1A_HUMAN	DEPDC1	physical	26496610
DOCK8_HUMAN	DOCK8	physical	26496610
RDH10_HUMAN	RDH10	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.