UniProt ID | MORC3_HUMAN | |
---|---|---|
UniProt AC | Q14149 | |
Protein Name | MORC family CW-type zinc finger protein 3 | |
Gene Name | MORC3 {ECO:0000312|HGNC:HGNC:23572} | |
Organism | Homo sapiens (Human). | |
Sequence Length | 939 | |
Subcellular Localization | Nucleus, nucleoplasm . Nucleus matrix . Nucleus, PML body . Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent. | |
Protein Description | Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism. [PubMed: 20501696 Sumoylated MORC3-NBs can also associate with PML-NBs] | |
Protein Sequence | MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
12 | Phosphorylation | PPRGIRLSALCPKFL CCCCEEHHHCCCCCC | 14.89 | 25159151 | |
79 | Ubiquitination | MTSDKLHKMLSFGFS CCHHHHHHHHHCCCC | 52.55 | - | |
82 | Phosphorylation | DKLHKMLSFGFSDKV HHHHHHHHCCCCCCE | 21.59 | - | |
105 | Ubiquitination | GLYGNGFKSGSMRLG EECCCCCCCCCCCCC | 56.13 | - | |
106 | Phosphorylation | LYGNGFKSGSMRLGK ECCCCCCCCCCCCCC | 33.56 | 24144214 | |
108 | Phosphorylation | GNGFKSGSMRLGKDA CCCCCCCCCCCCCCE | 14.07 | 24144214 | |
152 | Ubiquitination | VPIVAFNKHRQMINL EEEEEEHHHHHHHHH | 33.44 | - | |
191 | Sumoylation | ELDAIIGKKGTRIII HHHHHHCCCCCEEEE | 37.31 | 28112733 | |
191 | Ubiquitination | ELDAIIGKKGTRIII HHHHHHCCCCCEEEE | 37.31 | - | |
192 | Ubiquitination | LDAIIGKKGTRIIIW HHHHHCCCCCEEEEE | 61.37 | - | |
205 | Sumoylation | IWNLRSYKNATEFDF EEECCCCCCCCCCCC | 41.16 | - | |
205 | Sumoylation | IWNLRSYKNATEFDF EEECCCCCCCCCCCC | 41.16 | 28112733 | |
214 | Ubiquitination | ATEFDFEKDKYDIRI CCCCCCCCCCCCCCC | 60.56 | - | |
216 | Ubiquitination | EFDFEKDKYDIRIPE CCCCCCCCCCCCCCC | 56.76 | - | |
231 | Acetylation | DLDEITGKKGYKKQE CHHHHCCCCCCCHHH | 34.08 | 25953088 | |
231 | Sumoylation | DLDEITGKKGYKKQE CHHHHCCCCCCCHHH | 34.08 | 28112733 | |
231 | Ubiquitination | DLDEITGKKGYKKQE CHHHHCCCCCCCHHH | 34.08 | 21906983 | |
232 | Ubiquitination | LDEITGKKGYKKQER HHHHCCCCCCCHHHH | 69.67 | 21890473 | |
250 | Phosphorylation | IAPESDYSLRAYCSI HCCCCHHHHHHHHHH | 19.17 | 24719451 | |
254 | Phosphorylation | SDYSLRAYCSILYLK CHHHHHHHHHHEEEE | 4.74 | - | |
259 | Phosphorylation | RAYCSILYLKPRMQI HHHHHHEEEECCEEE | 15.83 | - | |
261 | Methylation | YCSILYLKPRMQIIL HHHHEEEECCEEEEC | 19.61 | - | |
261 | Ubiquitination | YCSILYLKPRMQIIL HHHHEEEECCEEEEC | 19.61 | - | |
274 | Ubiquitination | ILRGQKVKTQLVSKS ECCCCHHHHHHHCHH | 37.27 | - | |
280 | Sumoylation | VKTQLVSKSLAYIER HHHHHHCHHHHHHHH | 41.85 | 28112733 | |
280 | Ubiquitination | VKTQLVSKSLAYIER HHHHHHCHHHHHHHH | 41.85 | 21890473 | |
293 | Sumoylation | ERDVYRPKFLSKTVR HHCCCCCCCCCCEEE | 50.36 | 28112733 | |
293 | Ubiquitination | ERDVYRPKFLSKTVR HHCCCCCCCCCCEEE | 50.36 | 21890473 | |
296 | Phosphorylation | VYRPKFLSKTVRITF CCCCCCCCCEEEEEE | 29.43 | 26074081 | |
297 | Ubiquitination | YRPKFLSKTVRITFG CCCCCCCCEEEEEEE | 53.86 | - | |
298 | Phosphorylation | RPKFLSKTVRITFGF CCCCCCCEEEEEEEE | 16.19 | 26074081 | |
302 | Phosphorylation | LSKTVRITFGFNCRN CCCEEEEEEEECCCC | 13.72 | 26074081 | |
310 | Ubiquitination | FGFNCRNKDHYGIMM EEECCCCCCCEEEEE | 26.91 | - | |
313 | Phosphorylation | NCRNKDHYGIMMYHR CCCCCCCEEEEEEEH | 20.62 | 26074081 | |
318 | Phosphorylation | DHYGIMMYHRNRLIK CCEEEEEEEHHHHHH | 4.73 | 26074081 | |
325 | Ubiquitination | YHRNRLIKAYEKVGC EEHHHHHHHHHHHCC | 49.89 | - | |
329 | Ubiquitination | RLIKAYEKVGCQLRA HHHHHHHHHCCCCCC | 31.11 | - | |
353 | Ubiquitination | IIECNFLKPTHNKQD EEECCCCCCCCCCCC | 43.67 | - | |
358 | Ubiquitination | FLKPTHNKQDFDYTN CCCCCCCCCCCCCCC | 43.57 | - | |
377 | Ubiquitination | TITALGEKLNDYWNE EEEHHHHHHHHHHHH | 51.28 | 21906983 | |
378 | Ubiquitination | ITALGEKLNDYWNEM EEHHHHHHHHHHHHC | 5.26 | 21890473 | |
386 | Ubiquitination | NDYWNEMKVKKNTEY HHHHHHCCCCCCCCC | 44.73 | - | |
388 | Ubiquitination | YWNEMKVKKNTEYPL HHHHCCCCCCCCCCC | 34.48 | - | |
389 | Ubiquitination | WNEMKVKKNTEYPLN HHHCCCCCCCCCCCC | 72.58 | 21906983 | |
390 | Ubiquitination | NEMKVKKNTEYPLNL HHCCCCCCCCCCCCC | 32.21 | 21890473 | |
391 | Phosphorylation | EMKVKKNTEYPLNLP HCCCCCCCCCCCCCC | 45.86 | 24260401 | |
393 | Phosphorylation | KVKKNTEYPLNLPVE CCCCCCCCCCCCCHH | 15.81 | 24260401 | |
404 | Ubiquitination | LPVEDIQKRPDQTWV CCHHHHHHCCCCCEE | 67.25 | - | |
421 | Ubiquitination | DACLKWRKLPDGMDQ CHHCCCCCCCCCHHC | 64.36 | - | |
432 | Ubiquitination | GMDQLPEKWYCSNNP CHHCCCHHHCCCCCC | 41.33 | - | |
434 | Phosphorylation | DQLPEKWYCSNNPDP HCCCHHHCCCCCCCC | 9.32 | 17360941 | |
461 | Phosphorylation | DEDLVHPTYEKTYKK CCCCCCCCCHHHCHH | 29.45 | 28796482 | |
462 | Phosphorylation | EDLVHPTYEKTYKKT CCCCCCCCHHHCHHC | 21.63 | 28796482 | |
464 | Ubiquitination | LVHPTYEKTYKKTNK CCCCCCHHHCHHCCH | 46.90 | - | |
468 | Ubiquitination | TYEKTYKKTNKEKFR CCHHHCHHCCHHHHC | 47.09 | - | |
494 | Phosphorylation | AELLFRPTALSTPSF HHHEECCCCCCCCCC | 35.65 | 24732914 | |
497 | Phosphorylation | LFRPTALSTPSFSSP EECCCCCCCCCCCCC | 35.49 | 24732914 | |
498 | Phosphorylation | FRPTALSTPSFSSPK ECCCCCCCCCCCCCC | 24.65 | 21712546 | |
500 | Phosphorylation | PTALSTPSFSSPKES CCCCCCCCCCCCCHH | 37.54 | 21712546 | |
502 | Phosphorylation | ALSTPSFSSPKESVP CCCCCCCCCCCHHCC | 50.50 | 25159151 | |
503 | Phosphorylation | LSTPSFSSPKESVPR CCCCCCCCCCHHCCC | 37.67 | 21712546 | |
507 | Phosphorylation | SFSSPKESVPRRHLS CCCCCCHHCCCCCCC | 43.48 | 24732914 | |
514 | Phosphorylation | SVPRRHLSEGTNSYA HCCCCCCCCCCCHHH | 28.05 | 23401153 | |
517 | Phosphorylation | RRHLSEGTNSYATRL CCCCCCCCCHHHHHH | 19.55 | 28857561 | |
519 | Phosphorylation | HLSEGTNSYATRLLN CCCCCCCHHHHHHHH | 18.91 | 26434776 | |
520 | Phosphorylation | LSEGTNSYATRLLNN CCCCCCHHHHHHHHC | 17.67 | 23186163 | |
522 | Phosphorylation | EGTNSYATRLLNNHQ CCCCHHHHHHHHCCC | 17.39 | 26434776 | |
538 | Phosphorylation | PPQSEPESNSLKRRL CCCCCCCCHHHHHHH | 42.29 | 28555341 | |
540 | Phosphorylation | QSEPESNSLKRRLST CCCCCCHHHHHHHHH | 44.54 | 25159151 | |
542 | Ubiquitination | EPESNSLKRRLSTRS CCCCHHHHHHHHHHH | 34.98 | - | |
546 | Phosphorylation | NSLKRRLSTRSSILN HHHHHHHHHHHHHHH | 21.69 | 23401153 | |
547 | Phosphorylation | SLKRRLSTRSSILNA HHHHHHHHHHHHHHH | 38.88 | 23401153 | |
549 | Phosphorylation | KRRLSTRSSILNAKN HHHHHHHHHHHHHHH | 23.09 | 28450419 | |
550 | Phosphorylation | RRLSTRSSILNAKNR HHHHHHHHHHHHHHH | 28.01 | 25159151 | |
555 | Sumoylation | RSSILNAKNRRLSSQ HHHHHHHHHHHHHHH | 50.33 | 28112733 | |
555 | Ubiquitination | RSSILNAKNRRLSSQ HHHHHHHHHHHHHHH | 50.33 | - | |
560 | Phosphorylation | NAKNRRLSSQFENSV HHHHHHHHHHHHCCC | 21.93 | 23401153 | |
561 | O-linked_Glycosylation | AKNRRLSSQFENSVY HHHHHHHHHHHCCCC | 43.40 | 30379171 | |
561 | Phosphorylation | AKNRRLSSQFENSVY HHHHHHHHHHHCCCC | 43.40 | 25159151 | |
566 | Phosphorylation | LSSQFENSVYKGDDD HHHHHHCCCCCCCCC | 21.45 | 29978859 | |
568 | Phosphorylation | SQFENSVYKGDDDDE HHHHCCCCCCCCCCC | 14.74 | 23312004 | |
584 | Phosphorylation | VIILEENSTPKPAVD EEEEECCCCCCCCCC | 49.74 | 25159151 | |
585 | Phosphorylation | IILEENSTPKPAVDH EEEECCCCCCCCCCC | 47.08 | 25159151 | |
597 | Sumoylation | VDHDIDMKSEQSHVE CCCCCCCCCCCCHHH | 47.28 | - | |
597 | Sumoylation | VDHDIDMKSEQSHVE CCCCCCCCCCCCHHH | 47.28 | 20501696 | |
650 | Sumoylation | EVPSLVVKKEETVED CCCEEEECCCEECCC | 47.16 | - | |
650 | Sumoylation | EVPSLVVKKEETVED CCCEEEECCCEECCC | 47.16 | 20501696 | |
651 | Sumoylation | VPSLVVKKEETVEDE CCEEEECCCEECCCC | 49.53 | - | |
651 | Sumoylation | VPSLVVKKEETVEDE CCEEEECCCEECCCC | 49.53 | 20501696 | |
681 | Phosphorylation | AEAKIHETQETTDKS HHHHHHCCCHHCCCC | 19.97 | - | |
684 | Phosphorylation | KIHETQETTDKSADD HHHCCCHHCCCCCHH | 30.40 | 29759185 | |
685 | Phosphorylation | IHETQETTDKSADDA HHCCCHHCCCCCHHH | 40.45 | 29759185 | |
687 | Ubiquitination | ETQETTDKSADDAGC CCCHHCCCCCHHHCH | 45.51 | 21906983 | |
688 | Ubiquitination | TQETTDKSADDAGCQ CCHHCCCCCHHHCHH | 39.48 | 21890473 | |
710 | Ubiquitination | LLLVTEEKENYKRQC HEEEHHCHHHHHHHH | 45.06 | 21890473 | |
737 | Acetylation | RILEMNDKYVKKETC HHHHHCHHHCCHHHC | 47.11 | 12437819 | |
740 | Sumoylation | EMNDKYVKKETCHQS HHCHHHCCHHHCCCC | 41.63 | - | |
740 | Sumoylation | EMNDKYVKKETCHQS HHCHHHCCHHHCCCC | 41.63 | 20501696 | |
762 | Ubiquitination | LLESINGKSESPDHM EHHHHCCCCCCCHHH | 46.71 | - | |
763 | Phosphorylation | LESINGKSESPDHMV HHHHCCCCCCCHHHH | 44.71 | 30266825 | |
765 | Phosphorylation | SINGKSESPDHMVSQ HHCCCCCCCHHHHHH | 42.60 | 25159151 | |
771 | Phosphorylation | ESPDHMVSQYQQALE CCCHHHHHHHHHHHH | 18.65 | 23927012 | |
773 | Phosphorylation | PDHMVSQYQQALEEI CHHHHHHHHHHHHHH | 8.62 | 23927012 | |
785 | Ubiquitination | EEIERLKKQCSALQH HHHHHHHHHHHHHHH | 62.22 | - | |
794 | Sumoylation | CSALQHVKAECSQCS HHHHHHHHHHHHHCC | 36.02 | - | |
794 | Sumoylation | CSALQHVKAECSQCS HHHHHHHHHHHHHCC | 36.02 | 20501696 | |
794 | Ubiquitination | CSALQHVKAECSQCS HHHHHHHHHHHHHCC | 36.02 | - | |
798 | Phosphorylation | QHVKAECSQCSNNES HHHHHHHHHCCCCCC | 26.23 | - | |
801 | Phosphorylation | KAECSQCSNNESKSE HHHHHHCCCCCCHHH | 34.74 | 21712546 | |
805 | Phosphorylation | SQCSNNESKSEMDEM HHCCCCCCHHHHHHH | 43.54 | 21712546 | |
806 | Ubiquitination | QCSNNESKSEMDEMA HCCCCCCHHHHHHHH | 44.23 | 21906983 | |
807 | Phosphorylation | CSNNESKSEMDEMAV CCCCCCHHHHHHHHH | 47.64 | 21712546 | |
807 | Ubiquitination | CSNNESKSEMDEMAV CCCCCCHHHHHHHHH | 47.64 | 21890473 | |
825 | Ubiquitination | DVFRQLDKCSIERDQ HHHHHHHHCCCCHHH | 38.17 | 21890473 | |
826 | Ubiquitination | VFRQLDKCSIERDQY HHHHHHHCCCCHHHH | 5.03 | 21890473 | |
834 | Ubiquitination | SIERDQYKSEVELLE CCCHHHHHHHHHHHH | 34.21 | 21906983 | |
835 | Ubiquitination | IERDQYKSEVELLEM CCHHHHHHHHHHHHH | 41.77 | 21890473 | |
844 | Ubiquitination | VELLEMEKSQIRSQC HHHHHHHHHHHHHHH | 46.48 | 21906983 | |
845 | Phosphorylation | ELLEMEKSQIRSQCE HHHHHHHHHHHHHHH | 19.96 | 28122231 | |
845 | Ubiquitination | ELLEMEKSQIRSQCE HHHHHHHHHHHHHHH | 19.96 | 21890473 | |
855 | Sumoylation | RSQCEELKTEVEQLK HHHHHHHHHHHHHHH | 46.01 | - | |
855 | Sumoylation | RSQCEELKTEVEQLK HHHHHHHHHHHHHHH | 46.01 | 28112733 | |
855 | Ubiquitination | RSQCEELKTEVEQLK HHHHHHHHHHHHHHH | 46.01 | - | |
862 | Ubiquitination | KTEVEQLKSTNQQTA HHHHHHHHHCCCCCC | 55.73 | 21906983 | |
863 | Phosphorylation | TEVEQLKSTNQQTAT HHHHHHHHCCCCCCC | 40.98 | 30576142 | |
863 | Ubiquitination | TEVEQLKSTNQQTAT HHHHHHHHCCCCCCC | 40.98 | 21890473 | |
864 | Phosphorylation | EVEQLKSTNQQTATD HHHHHHHCCCCCCCC | 35.14 | 29449344 | |
868 | Phosphorylation | LKSTNQQTATDVSTS HHHCCCCCCCCCCCC | 23.04 | 29449344 | |
870 | Phosphorylation | STNQQTATDVSTSSN HCCCCCCCCCCCCCC | 40.08 | 29449344 | |
873 | Phosphorylation | QQTATDVSTSSNIEE CCCCCCCCCCCCHHH | 25.94 | 30576142 | |
874 | Phosphorylation | QTATDVSTSSNIEES CCCCCCCCCCCHHHH | 35.70 | 21712546 | |
875 | Phosphorylation | TATDVSTSSNIEESV CCCCCCCCCCHHHHH | 17.55 | 21712546 | |
876 | Phosphorylation | ATDVSTSSNIEESVN CCCCCCCCCHHHHHH | 41.75 | 21712546 | |
881 | Phosphorylation | TSSNIEESVNHMDGE CCCCHHHHHHCCCCC | 18.54 | 29449344 | |
891 | Ubiquitination | HMDGESLKLRSLRVN CCCCCCCCHHEEEEE | 51.65 | 21890473 | |
892 | Ubiquitination | MDGESLKLRSLRVNV CCCCCCCHHEEEEEH | 5.65 | 21890473 | |
894 | Phosphorylation | GESLKLRSLRVNVGQ CCCCCHHEEEEEHHH | 30.85 | - |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MORC3_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MORC3_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
HD_HUMAN | HTT | physical | 26496610 | |
SNTB1_HUMAN | SNTB1 | physical | 26496610 | |
MOGS_HUMAN | MOGS | physical | 26496610 | |
DYL1_HUMAN | DYNLL1 | physical | 26496610 | |
CRIPT_HUMAN | CRIPT | physical | 26496610 | |
TRIB1_HUMAN | TRIB1 | physical | 26496610 | |
SYNE2_HUMAN | SYNE2 | physical | 26496610 | |
DEP1A_HUMAN | DEPDC1 | physical | 26496610 | |
DOCK8_HUMAN | DOCK8 | physical | 26496610 | |
RDH10_HUMAN | RDH10 | physical | 26496610 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...