MORC3_HUMAN - dbPTM
MORC3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MORC3_HUMAN
UniProt AC Q14149
Protein Name MORC family CW-type zinc finger protein 3
Gene Name MORC3 {ECO:0000312|HGNC:HGNC:23572}
Organism Homo sapiens (Human).
Sequence Length 939
Subcellular Localization Nucleus, nucleoplasm . Nucleus matrix . Nucleus, PML body . Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent.
Protein Description Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism. [PubMed: 20501696 Sumoylated MORC3-NBs can also associate with PML-NBs]
Protein Sequence MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationPPRGIRLSALCPKFL
CCCCEEHHHCCCCCC
14.8925159151
79UbiquitinationMTSDKLHKMLSFGFS
CCHHHHHHHHHCCCC
52.55-
82PhosphorylationDKLHKMLSFGFSDKV
HHHHHHHHCCCCCCE
21.59-
105UbiquitinationGLYGNGFKSGSMRLG
EECCCCCCCCCCCCC
56.13-
106PhosphorylationLYGNGFKSGSMRLGK
ECCCCCCCCCCCCCC
33.5624144214
108PhosphorylationGNGFKSGSMRLGKDA
CCCCCCCCCCCCCCE
14.0724144214
152UbiquitinationVPIVAFNKHRQMINL
EEEEEEHHHHHHHHH
33.44-
191SumoylationELDAIIGKKGTRIII
HHHHHHCCCCCEEEE
37.3128112733
191UbiquitinationELDAIIGKKGTRIII
HHHHHHCCCCCEEEE
37.31-
192UbiquitinationLDAIIGKKGTRIIIW
HHHHHCCCCCEEEEE
61.37-
205SumoylationIWNLRSYKNATEFDF
EEECCCCCCCCCCCC
41.16-
205SumoylationIWNLRSYKNATEFDF
EEECCCCCCCCCCCC
41.1628112733
214UbiquitinationATEFDFEKDKYDIRI
CCCCCCCCCCCCCCC
60.56-
216UbiquitinationEFDFEKDKYDIRIPE
CCCCCCCCCCCCCCC
56.76-
231AcetylationDLDEITGKKGYKKQE
CHHHHCCCCCCCHHH
34.0825953088
231SumoylationDLDEITGKKGYKKQE
CHHHHCCCCCCCHHH
34.0828112733
231UbiquitinationDLDEITGKKGYKKQE
CHHHHCCCCCCCHHH
34.0821906983
232UbiquitinationLDEITGKKGYKKQER
HHHHCCCCCCCHHHH
69.6721890473
250PhosphorylationIAPESDYSLRAYCSI
HCCCCHHHHHHHHHH
19.1724719451
254PhosphorylationSDYSLRAYCSILYLK
CHHHHHHHHHHEEEE
4.74-
259PhosphorylationRAYCSILYLKPRMQI
HHHHHHEEEECCEEE
15.83-
261MethylationYCSILYLKPRMQIIL
HHHHEEEECCEEEEC
19.61-
261UbiquitinationYCSILYLKPRMQIIL
HHHHEEEECCEEEEC
19.61-
274UbiquitinationILRGQKVKTQLVSKS
ECCCCHHHHHHHCHH
37.27-
280SumoylationVKTQLVSKSLAYIER
HHHHHHCHHHHHHHH
41.8528112733
280UbiquitinationVKTQLVSKSLAYIER
HHHHHHCHHHHHHHH
41.8521890473
293SumoylationERDVYRPKFLSKTVR
HHCCCCCCCCCCEEE
50.3628112733
293UbiquitinationERDVYRPKFLSKTVR
HHCCCCCCCCCCEEE
50.3621890473
296PhosphorylationVYRPKFLSKTVRITF
CCCCCCCCCEEEEEE
29.4326074081
297UbiquitinationYRPKFLSKTVRITFG
CCCCCCCCEEEEEEE
53.86-
298PhosphorylationRPKFLSKTVRITFGF
CCCCCCCEEEEEEEE
16.1926074081
302PhosphorylationLSKTVRITFGFNCRN
CCCEEEEEEEECCCC
13.7226074081
310UbiquitinationFGFNCRNKDHYGIMM
EEECCCCCCCEEEEE
26.91-
313PhosphorylationNCRNKDHYGIMMYHR
CCCCCCCEEEEEEEH
20.6226074081
318PhosphorylationDHYGIMMYHRNRLIK
CCEEEEEEEHHHHHH
4.7326074081
325UbiquitinationYHRNRLIKAYEKVGC
EEHHHHHHHHHHHCC
49.89-
329UbiquitinationRLIKAYEKVGCQLRA
HHHHHHHHHCCCCCC
31.11-
353UbiquitinationIIECNFLKPTHNKQD
EEECCCCCCCCCCCC
43.67-
358UbiquitinationFLKPTHNKQDFDYTN
CCCCCCCCCCCCCCC
43.57-
377UbiquitinationTITALGEKLNDYWNE
EEEHHHHHHHHHHHH
51.2821906983
378UbiquitinationITALGEKLNDYWNEM
EEHHHHHHHHHHHHC
5.2621890473
386UbiquitinationNDYWNEMKVKKNTEY
HHHHHHCCCCCCCCC
44.73-
388UbiquitinationYWNEMKVKKNTEYPL
HHHHCCCCCCCCCCC
34.48-
389UbiquitinationWNEMKVKKNTEYPLN
HHHCCCCCCCCCCCC
72.5821906983
390UbiquitinationNEMKVKKNTEYPLNL
HHCCCCCCCCCCCCC
32.2121890473
391PhosphorylationEMKVKKNTEYPLNLP
HCCCCCCCCCCCCCC
45.8624260401
393PhosphorylationKVKKNTEYPLNLPVE
CCCCCCCCCCCCCHH
15.8124260401
404UbiquitinationLPVEDIQKRPDQTWV
CCHHHHHHCCCCCEE
67.25-
421UbiquitinationDACLKWRKLPDGMDQ
CHHCCCCCCCCCHHC
64.36-
432UbiquitinationGMDQLPEKWYCSNNP
CHHCCCHHHCCCCCC
41.33-
434PhosphorylationDQLPEKWYCSNNPDP
HCCCHHHCCCCCCCC
9.3217360941
461PhosphorylationDEDLVHPTYEKTYKK
CCCCCCCCCHHHCHH
29.4528796482
462PhosphorylationEDLVHPTYEKTYKKT
CCCCCCCCHHHCHHC
21.6328796482
464UbiquitinationLVHPTYEKTYKKTNK
CCCCCCHHHCHHCCH
46.90-
468UbiquitinationTYEKTYKKTNKEKFR
CCHHHCHHCCHHHHC
47.09-
494PhosphorylationAELLFRPTALSTPSF
HHHEECCCCCCCCCC
35.6524732914
497PhosphorylationLFRPTALSTPSFSSP
EECCCCCCCCCCCCC
35.4924732914
498PhosphorylationFRPTALSTPSFSSPK
ECCCCCCCCCCCCCC
24.6521712546
500PhosphorylationPTALSTPSFSSPKES
CCCCCCCCCCCCCHH
37.5421712546
502PhosphorylationALSTPSFSSPKESVP
CCCCCCCCCCCHHCC
50.5025159151
503PhosphorylationLSTPSFSSPKESVPR
CCCCCCCCCCHHCCC
37.6721712546
507PhosphorylationSFSSPKESVPRRHLS
CCCCCCHHCCCCCCC
43.4824732914
514PhosphorylationSVPRRHLSEGTNSYA
HCCCCCCCCCCCHHH
28.0523401153
517PhosphorylationRRHLSEGTNSYATRL
CCCCCCCCCHHHHHH
19.5528857561
519PhosphorylationHLSEGTNSYATRLLN
CCCCCCCHHHHHHHH
18.9126434776
520PhosphorylationLSEGTNSYATRLLNN
CCCCCCHHHHHHHHC
17.6723186163
522PhosphorylationEGTNSYATRLLNNHQ
CCCCHHHHHHHHCCC
17.3926434776
538PhosphorylationPPQSEPESNSLKRRL
CCCCCCCCHHHHHHH
42.2928555341
540PhosphorylationQSEPESNSLKRRLST
CCCCCCHHHHHHHHH
44.5425159151
542UbiquitinationEPESNSLKRRLSTRS
CCCCHHHHHHHHHHH
34.98-
546PhosphorylationNSLKRRLSTRSSILN
HHHHHHHHHHHHHHH
21.6923401153
547PhosphorylationSLKRRLSTRSSILNA
HHHHHHHHHHHHHHH
38.8823401153
549PhosphorylationKRRLSTRSSILNAKN
HHHHHHHHHHHHHHH
23.0928450419
550PhosphorylationRRLSTRSSILNAKNR
HHHHHHHHHHHHHHH
28.0125159151
555SumoylationRSSILNAKNRRLSSQ
HHHHHHHHHHHHHHH
50.3328112733
555UbiquitinationRSSILNAKNRRLSSQ
HHHHHHHHHHHHHHH
50.33-
560PhosphorylationNAKNRRLSSQFENSV
HHHHHHHHHHHHCCC
21.9323401153
561O-linked_GlycosylationAKNRRLSSQFENSVY
HHHHHHHHHHHCCCC
43.4030379171
561PhosphorylationAKNRRLSSQFENSVY
HHHHHHHHHHHCCCC
43.4025159151
566PhosphorylationLSSQFENSVYKGDDD
HHHHHHCCCCCCCCC
21.4529978859
568PhosphorylationSQFENSVYKGDDDDE
HHHHCCCCCCCCCCC
14.7423312004
584PhosphorylationVIILEENSTPKPAVD
EEEEECCCCCCCCCC
49.7425159151
585PhosphorylationIILEENSTPKPAVDH
EEEECCCCCCCCCCC
47.0825159151
597SumoylationVDHDIDMKSEQSHVE
CCCCCCCCCCCCHHH
47.28-
597SumoylationVDHDIDMKSEQSHVE
CCCCCCCCCCCCHHH
47.2820501696
650SumoylationEVPSLVVKKEETVED
CCCEEEECCCEECCC
47.16-
650SumoylationEVPSLVVKKEETVED
CCCEEEECCCEECCC
47.1620501696
651SumoylationVPSLVVKKEETVEDE
CCEEEECCCEECCCC
49.53-
651SumoylationVPSLVVKKEETVEDE
CCEEEECCCEECCCC
49.5320501696
681PhosphorylationAEAKIHETQETTDKS
HHHHHHCCCHHCCCC
19.97-
684PhosphorylationKIHETQETTDKSADD
HHHCCCHHCCCCCHH
30.4029759185
685PhosphorylationIHETQETTDKSADDA
HHCCCHHCCCCCHHH
40.4529759185
687UbiquitinationETQETTDKSADDAGC
CCCHHCCCCCHHHCH
45.5121906983
688UbiquitinationTQETTDKSADDAGCQ
CCHHCCCCCHHHCHH
39.4821890473
710UbiquitinationLLLVTEEKENYKRQC
HEEEHHCHHHHHHHH
45.0621890473
737AcetylationRILEMNDKYVKKETC
HHHHHCHHHCCHHHC
47.1112437819
740SumoylationEMNDKYVKKETCHQS
HHCHHHCCHHHCCCC
41.63-
740SumoylationEMNDKYVKKETCHQS
HHCHHHCCHHHCCCC
41.6320501696
762UbiquitinationLLESINGKSESPDHM
EHHHHCCCCCCCHHH
46.71-
763PhosphorylationLESINGKSESPDHMV
HHHHCCCCCCCHHHH
44.7130266825
765PhosphorylationSINGKSESPDHMVSQ
HHCCCCCCCHHHHHH
42.6025159151
771PhosphorylationESPDHMVSQYQQALE
CCCHHHHHHHHHHHH
18.6523927012
773PhosphorylationPDHMVSQYQQALEEI
CHHHHHHHHHHHHHH
8.6223927012
785UbiquitinationEEIERLKKQCSALQH
HHHHHHHHHHHHHHH
62.22-
794SumoylationCSALQHVKAECSQCS
HHHHHHHHHHHHHCC
36.02-
794SumoylationCSALQHVKAECSQCS
HHHHHHHHHHHHHCC
36.0220501696
794UbiquitinationCSALQHVKAECSQCS
HHHHHHHHHHHHHCC
36.02-
798PhosphorylationQHVKAECSQCSNNES
HHHHHHHHHCCCCCC
26.23-
801PhosphorylationKAECSQCSNNESKSE
HHHHHHCCCCCCHHH
34.7421712546
805PhosphorylationSQCSNNESKSEMDEM
HHCCCCCCHHHHHHH
43.5421712546
806UbiquitinationQCSNNESKSEMDEMA
HCCCCCCHHHHHHHH
44.2321906983
807PhosphorylationCSNNESKSEMDEMAV
CCCCCCHHHHHHHHH
47.6421712546
807UbiquitinationCSNNESKSEMDEMAV
CCCCCCHHHHHHHHH
47.6421890473
825UbiquitinationDVFRQLDKCSIERDQ
HHHHHHHHCCCCHHH
38.1721890473
826UbiquitinationVFRQLDKCSIERDQY
HHHHHHHCCCCHHHH
5.0321890473
834UbiquitinationSIERDQYKSEVELLE
CCCHHHHHHHHHHHH
34.2121906983
835UbiquitinationIERDQYKSEVELLEM
CCHHHHHHHHHHHHH
41.7721890473
844UbiquitinationVELLEMEKSQIRSQC
HHHHHHHHHHHHHHH
46.4821906983
845PhosphorylationELLEMEKSQIRSQCE
HHHHHHHHHHHHHHH
19.9628122231
845UbiquitinationELLEMEKSQIRSQCE
HHHHHHHHHHHHHHH
19.9621890473
855SumoylationRSQCEELKTEVEQLK
HHHHHHHHHHHHHHH
46.01-
855SumoylationRSQCEELKTEVEQLK
HHHHHHHHHHHHHHH
46.0128112733
855UbiquitinationRSQCEELKTEVEQLK
HHHHHHHHHHHHHHH
46.01-
862UbiquitinationKTEVEQLKSTNQQTA
HHHHHHHHHCCCCCC
55.7321906983
863PhosphorylationTEVEQLKSTNQQTAT
HHHHHHHHCCCCCCC
40.9830576142
863UbiquitinationTEVEQLKSTNQQTAT
HHHHHHHHCCCCCCC
40.9821890473
864PhosphorylationEVEQLKSTNQQTATD
HHHHHHHCCCCCCCC
35.1429449344
868PhosphorylationLKSTNQQTATDVSTS
HHHCCCCCCCCCCCC
23.0429449344
870PhosphorylationSTNQQTATDVSTSSN
HCCCCCCCCCCCCCC
40.0829449344
873PhosphorylationQQTATDVSTSSNIEE
CCCCCCCCCCCCHHH
25.9430576142
874PhosphorylationQTATDVSTSSNIEES
CCCCCCCCCCCHHHH
35.7021712546
875PhosphorylationTATDVSTSSNIEESV
CCCCCCCCCCHHHHH
17.5521712546
876PhosphorylationATDVSTSSNIEESVN
CCCCCCCCCHHHHHH
41.7521712546
881PhosphorylationTSSNIEESVNHMDGE
CCCCHHHHHHCCCCC
18.5429449344
891UbiquitinationHMDGESLKLRSLRVN
CCCCCCCCHHEEEEE
51.6521890473
892UbiquitinationMDGESLKLRSLRVNV
CCCCCCCHHEEEEEH
5.6521890473
894PhosphorylationGESLKLRSLRVNVGQ
CCCCCHHEEEEEHHH
30.85-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseICP0P08393
PMID:32416261

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MORC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MORC3_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HD_HUMANHTTphysical
26496610
SNTB1_HUMANSNTB1physical
26496610
MOGS_HUMANMOGSphysical
26496610
DYL1_HUMANDYNLL1physical
26496610
CRIPT_HUMANCRIPTphysical
26496610
TRIB1_HUMANTRIB1physical
26496610
SYNE2_HUMANSYNE2physical
26496610
DEP1A_HUMANDEPDC1physical
26496610
DOCK8_HUMANDOCK8physical
26496610
RDH10_HUMANRDH10physical
26496610

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MORC3_HUMAN

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Related Literatures of Post-Translational Modification

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